pleckstrin

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Synonym

Pleckstrin, Platelet p47 protein, pleckstrin, PLEK, FLJ27168

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:15.40 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:17.60 artery/aorta:89.90 vein:66.60 lymphnode:80.90 peripheral blood:437.20 spleen:208 thymus:64.40 bone marrow:196.80 adipose:40.30 bone:102.40 skin:81.60
GeneChip cerebrum:5.28 cerebellum:4.97 brain stem:5.54 corpus callosum/glia:5.58 pineal gland:- peripheral nerve:5.44 spine:5.92 retina:- eye:- artery/aorta:5.51 vein:5.45 lymphnode:7.84 peripheral blood:- spleen:7.95 thymus:6.14 bone marrow:8.83 adipose:6.22 bone:- skin:5.41
CAGE cerebrum:1.68 cerebellum:- brain stem:2.64 corpus callosum/glia:2.93 pineal gland:1.44 peripheral nerve:- spine:2.49 retina:- eye:- artery/aorta:2.50 vein:3.63 lymphnode:4.15 peripheral blood:- spleen:4.77 thymus:2.90 bone marrow:- adipose:4.23 bone:- skin:-
RNA-seq cerebrum:1.77 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.48 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.34 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:47.40 prostate:- ovary:74.50 testis:4.30 heart:12.80 muscle:- esophagus:- stomach:- intestine:32.40 colon:25.40     liver/hepato:-        lung:351.90    bladder:376.80 kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:18.60 salivary:-
GeneChip uterus:5.27 placenta:6.43 prostate:4.99 ovary:5.09 testis:4.71 heart:5.46 muscle:4.99 esophagus:5.17 stomach:5.81 intestine:5.96 colon:5.90 liver/hepato:5.91 lung:6.84 bladder:- kidney:5.10 pituitary:4.87 thyroid/parathyroid:5.08 adrenal gland:5.30 pancreas:5.55 breast:5.59 salivary:5.31
CAGE uterus:1.98 placenta:3.00 prostate:2.49 ovary:2.48 testis:2.29 heart:2.25 muscle:1.54 esophagus:2.31 stomach:- intestine:2.35 colon:1.92     liver/hepato:2.54    lung:3.70 bladder:2.35 kidney:2.32 pituitary:1.49 thyroid/parathyroid:2.30 adrenal gland:- pancreas:2.08 breast:2.53 salivary:2.01
RNA-seq uterus:- placenta:- prostate:2.65 ovary:2.32 testis:1.98 heart:1.65 muscle:0.73 esophagus:- stomach:- intestine:- colon:0.88     liver/hepato:1.70        lung:4.06    bladder:- kidney:1.68 pituitary:- thyroid/parathyroid:1.52 adrenal gland:4.86 pancreas:- breast:2.93 salivary:-

Gene Information

IDs

Refseq ID NM_002664
Gene ID 5341
Unigene ID Hs.468840
Probe set ID 203471_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000115956
GTEx ID ENSG00000115956

Orthologous Gene

Mouse[3]  NM_019549
Rat [0]  

Chromosomal Region

2p14  [68,592,305  -  68,624,585]

Gene Family (Interpro ID)

IPR000591  DEP domain
IPR001849  Pleckstrin homology
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

2768345
2897630
6457647
6885823
7559487
7782310
8208296
8615792
8694752
8999861
9060471
10497244
10860665
10995449
12054651
12456365
12477932
14630798
14702039
15489334
15573383
15698571
15761153
15815621
19043545
19546854
19722192
19913121
19944685
19946888
20190752
20628086
21393855
21833088
21890473
22190364

Gene Ontology  (GO ID)

Biological Process

GO:0031532  actin cytoskeleton reorganization
GO:0007596  blood coagulation
GO:0030030  cell projection organization
GO:0030866  cortical actin cytoskeleton organization
GO:0002244  hemopoietic progenitor cell differentiation
GO:0030845  inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway
GO:0007229  integrin-mediated signaling pathway
GO:0050849  negative regulation of calcium-mediated signaling
GO:0045744  negative regulation of G-protein coupled receptor protein signaling pathway
GO:0010920  negative regulation of inositol phosphate biosynthetic process
GO:0046488  phosphatidylinositol metabolic process
GO:0030168  platelet activation
GO:0070527  platelet aggregation
GO:0002576  platelet degranulation
GO:0032233  positive regulation of actin filament bundle formation
GO:0030836  positive regulation of actin filament depolymerization
GO:0010925  positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0033625  positive regulation of integrin activation
GO:0010572  positive regulation of platelet activation
GO:0070528  protein kinase C signaling cascade
GO:0070560  protein secretion by platelet
GO:0060305  regulation of cell diameter
GO:0031529  ruffle organization
GO:0070493  thrombin receptor signaling pathway
GO:0006904  vesicle docking during exocytosis

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005576  extracellular region
GO:0032587  ruffle membrane

Molecular Function

GO:0043325  phosphatidylinositol-3,4-bisphosphate binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0005080  protein kinase C binding