phosphoribosyl pyrophosphate amidotransferase

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Synonym

GPAT, PPAT, ATASE, phosphoribosyl pyrophosphate amidotransferase, Amidophosphoribosyltransferase precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:47.40 cerebellum:50.40 brain stem:- corpus callosum/glia:29.20 pineal gland:148.30 peripheral nerve:30.70 spine:- retina:- eye:29.40 artery/aorta:60 vein:- lymphnode:40.40 peripheral blood:- spleen:- thymus:51.50 bone marrow:- adipose:- bone:38.40 skin:14.40
GeneChip cerebrum:5.12 cerebellum:5.02 brain stem:5.21 corpus callosum/glia:5.15 pineal gland:- peripheral nerve:4.88 spine:5.06 retina:- eye:- artery/aorta:4.50 vein:5.06 lymphnode:4.77 peripheral blood:- spleen:4.77 thymus:5.69 bone marrow:5.14 adipose:4.56 bone:- skin:4.79
CAGE cerebrum:2.30 cerebellum:- brain stem:2.17 corpus callosum/glia:1.96 pineal gland:2.01 peripheral nerve:- spine:2.10 retina:- eye:- artery/aorta:1.43 vein:1.23 lymphnode:1.76 peripheral blood:- spleen:1.74 thymus:2.47 bone marrow:- adipose:1.60 bone:- skin:-
RNA-seq cerebrum:2.49 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.17 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:65.60 prostate:78.90 ovary:37.30 testis:43.30 heart:25.50 muscle:40.20 esophagus:- stomach:21.20 intestine:64.80 colon:152.60     liver/hepato:73.90        lung:63.50    bladder:125.60 kidney:52 pituitary:1739.70 thyroid/parathyroid:163.70 adrenal gland:- pancreas:26.70 breast:65.10 salivary:-
GeneChip uterus:5 placenta:5.24 prostate:4.73 ovary:5.18 testis:5.54 heart:4.86 muscle:5.09 esophagus:4.76 stomach:4.79 intestine:5.13 colon:4.93 liver/hepato:4.87 lung:4.62 bladder:- kidney:4.82 pituitary:4.71 thyroid/parathyroid:4.57 adrenal gland:4.87 pancreas:5.17 breast:4.94 salivary:4.92
CAGE uterus:1.89 placenta:2.00 prostate:1.67 ovary:2.13 testis:2.17 heart:1.62 muscle:1.52 esophagus:1.72 stomach:- intestine:1.37 colon:1.66     liver/hepato:2.14    lung:1.17 bladder:1.93 kidney:1.89 pituitary:1.95 thyroid/parathyroid:1.73 adrenal gland:- pancreas:2.34 breast:1.36 salivary:1.82
RNA-seq uterus:- placenta:- prostate:2.16 ovary:2.82 testis:2.81 heart:0.99 muscle:1.52 esophagus:- stomach:- intestine:- colon:1.97     liver/hepato:1.83        lung:1.39    bladder:- kidney:2.20 pituitary:- thyroid/parathyroid:1.91 adrenal gland:2.25 pancreas:- breast:1.65 salivary:-

Gene Information

IDs

Refseq ID NM_002703
Gene ID 5471
Unigene ID Hs.331420
Probe set ID 209434_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000128059
GTEx ID ENSG00000128059

Orthologous Gene

Mouse[2]  NM_172146
Rat[2]  NM_057198

Chromosomal Region

4q12  [57,259,528  -  57,301,781]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

752480
1574589
8106516
8125298
8380692
9108165
10593947
10597272
12477932
15489334
16196087
16344560
21139048
21890473
21906983
21963094
21988832
22505724
22678362
22863883
22939629
23184937
23275563
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0006189  'de novo' IMP biosynthetic process
GO:0032869  cellular response to insulin stimulus
GO:0000082  G1/S transition of mitotic cell cycle
GO:0006543  glutamine catabolic process
GO:0001822  kidney development
GO:0007595  lactation
GO:0060135  maternal process involved in female pregnancy
GO:0055086  nucleobase, nucleoside and nucleotide metabolic process
GO:0009116  nucleoside metabolic process
GO:0031100  organ regeneration
GO:0051289  protein homotetramerization
GO:0009113  purine base biosynthetic process
GO:0006144  purine base metabolic process
GO:0006164  purine nucleotide biosynthetic process
GO:0009168  purine ribonucleoside monophosphate biosynthetic process

Cellular Component

GO:0005829  cytosol

Molecular Function

GO:0051539  4 iron, 4 sulfur cluster binding
GO:0004044  amidophosphoribosyltransferase activity
GO:0046872  metal ion binding