sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

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Synonym

Semacl1, MGC126383, M-Sema F, SEMAI, MGC126382, KIAA1739, Semaf, Semaphorin-4C precursor, SEMA4C, UNQ5855/PRO34487, FLJ20369, M-SEMA-F

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:30.80 cerebellum:37.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:41.10 artery/aorta:30 vein:- lymphnode:- peripheral blood:36.40 spleen:56.70 thymus:- bone marrow:- adipose:40.30 bone:- skin:28.80
GeneChip cerebrum:7.25 cerebellum:7.43 brain stem:7.21 corpus callosum/glia:7.81 pineal gland:- peripheral nerve:7.93 spine:7.43 retina:- eye:- artery/aorta:7.55 vein:7.59 lymphnode:7.11 peripheral blood:- spleen:8.11 thymus:6.17 bone marrow:6.89 adipose:7.14 bone:- skin:6.96
CAGE cerebrum:2.68 cerebellum:- brain stem:3.25 corpus callosum/glia:3.62 pineal gland:2.25 peripheral nerve:- spine:2.83 retina:- eye:- artery/aorta:2.98 vein:2.31 lymphnode:1.94 peripheral blood:- spleen:3.06 thymus:1.03 bone marrow:- adipose:2.05 bone:- skin:-
RNA-seq cerebrum:3.22 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.41 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.31 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:40.10 prostate:45.10 ovary:- testis:- heart:- muscle:60.30 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:19.60    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:27.90 salivary:-
GeneChip uterus:7.60 placenta:7.47 prostate:7.21 ovary:7.32 testis:6.18 heart:7.30 muscle:6.80 esophagus:7.29 stomach:7.29 intestine:7.11 colon:7.31 liver/hepato:7.14 lung:7.44 bladder:- kidney:6.88 pituitary:6.93 thyroid/parathyroid:6.84 adrenal gland:7.09 pancreas:7.45 breast:7.47 salivary:6.74
CAGE uterus:3.04 placenta:3.32 prostate:3.19 ovary:2.81 testis:1.86 heart:2.65 muscle:1.48 esophagus:2.65 stomach:- intestine:1.86 colon:2.59     liver/hepato:1.86    lung:2.49 bladder:3.21 kidney:1.81 pituitary:1.84 thyroid/parathyroid:2.06 adrenal gland:- pancreas:1.59 breast:1.80 salivary:2.26
RNA-seq uterus:- placenta:- prostate:4.28 ovary:3.54 testis:2.52 heart:1.63 muscle:1.50 esophagus:- stomach:- intestine:- colon:3.61     liver/hepato:2.13        lung:3.88    bladder:- kidney:2.13 pituitary:- thyroid/parathyroid:2.41 adrenal gland:3.81 pancreas:- breast:2.35 salivary:-

Gene Information

IDs

Refseq ID NM_017789
Gene ID 54910
Unigene ID Hs.516220
Probe set ID 219039_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000168758
GTEx ID ENSG00000168758

Orthologous Gene

Mouse[1]  NM_001126047
Rat[1]  NM_001106902

Chromosomal Region

2q11.2  [97,525,453  -  97,536,494]

Gene Family (Interpro ID)

IPR003659  Plexin/semaphorin/integrin
IPR001627  Semaphorin/CD100 antigen
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

7656991
9464278
10318831
11134026
11162505
11214970
12477932
12975309
15489334
15978582
17498836
20959347
21139048
21890473
22268729
22944267

Gene Ontology  (GO ID)

Biological Process

GO:0021535  cell migration in hindbrain
GO:0021549  cerebellum development
GO:0042692  muscle cell differentiation
GO:0001843  neural tube closure
GO:0032874  positive regulation of stress-activated MAPK cascade

Cellular Component

GO:0030054  cell junction
GO:0016021  integral to membrane
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane
GO:0030672  synaptic vesicle membrane

Molecular Function

GO:0004872  receptor activity