protein kinase, AMP-activated, alpha 1 catalytic subunit

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Synonym

PRKAA1, MGC57364, AMPKa1, AMPK alpha-1 chain, AMPK1, MGC33776

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:55.70

cerebellum:12.60

brain stem:-

corpus callosum/glia:-

pineal gland:296.70

peripheral nerve:61.30

spine:112.30

retina:593.20

eye:182.20

artery/aorta:60

vein:866.40

lymphnode:151.70

peripheral blood:564.80

spleen:75.60

thymus:25.80

bone marrow:196.80

adipose:161.30

bone:191.90

skin:542.40

GeneChip

cerebrum:3.62

cerebellum:3.53

brain stem:3.96

corpus callosum/glia:3.71

pineal gland:-

peripheral nerve:3.80

spine:3.80

retina:-

eye:-

artery/aorta:3.82

vein:4.37

lymphnode:3.96

peripheral blood:-

spleen:4.29

thymus:4.62

bone marrow:5.82

adipose:4.39

bone:-

skin:4.49

CAGE

cerebrum:3.16

cerebellum:-

brain stem:3.90

corpus callosum/glia:3.82

pineal gland:3.17

peripheral nerve:-

spine:3.37

retina:-

eye:-

artery/aorta:3.71

vein:3.72

lymphnode:3.81

peripheral blood:-

spleen:4.02

thymus:3.69

bone marrow:-

adipose:4.52

bone:-

skin:-

RNA-seq

cerebrum:3.27

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.89

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.28

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:164

placenta:167.60

prostate:202.80

ovary:149.10

testis:190.40

heart:89.40

muscle:40.20

esophagus:-

stomach:424.80

intestine:162

colon:144.20

liver/hepato:84.40

lung:268.80

bladder:125.60

kidney:62.40

pituitary:116

thyroid/parathyroid:491.20

adrenal gland:101.60

pancreas:391.20

breast:390.30

salivary:-

GeneChip

uterus:4.04

placenta:4.58

prostate:4.51

ovary:4.01

testis:7.31

heart:4.22

muscle:3.71

esophagus:3.98

stomach:4.32

intestine:4.51

colon:3.99

liver/hepato:4.32

lung:3.98

bladder:-

kidney:3.80

pituitary:3.40

thyroid/parathyroid:3.94

adrenal gland:3.47

pancreas:4.32

breast:3.67

salivary:4.07

CAGE

uterus:4.21

placenta:3.59

prostate:4.17

ovary:4.17

testis:3.98

heart:3.56

muscle:3.59

esophagus:3.96

stomach:-

intestine:4.27

colon:3.63

liver/hepato:4.38

lung:3.95

bladder:4.31

kidney:4.32

pituitary:3.42

thyroid/parathyroid:4.05

adrenal gland:-

pancreas:3.50

breast:3.47

salivary:3.85

RNA-seq

uterus:-

placenta:-

prostate:4.39

ovary:3.97

testis:3.88

heart:3.21

muscle:2.72

esophagus:-

stomach:-

intestine:-

colon:4.11

liver/hepato:4.30

lung:4.55

bladder:-

kidney:4.33

pituitary:-

thyroid/parathyroid:4.35

adrenal gland:4.25

pancreas:-

breast:3.89

salivary:-

IDs

Refseq ID	NM_006251
Gene ID	5562
Unigene ID	Hs.433222
Probe set ID	209799_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000132356
GTEx ID	ENSG00000132356

Orthologous Gene

Mouse[1]	NM_001013367
Rat [0]

Chromosomal Region

5p13.1 [40,759,481 - 40,798,476]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0006914	autophagy
GO:0007050	cell cycle arrest
GO:0071361	cellular response to ethanol
GO:0042149	cellular response to glucose starvation
GO:0070301	cellular response to hydrogen peroxide
GO:0071456	cellular response to hypoxia
GO:0031669	cellular response to nutrient levels
GO:0006695	cholesterol biosynthetic process
GO:0009631	cold acclimation
GO:0006633	fatty acid biosynthetic process
GO:0055089	fatty acid homeostasis
GO:0019395	fatty acid oxidation
GO:0042593	glucose homeostasis
GO:0006006	glucose metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0008610	lipid biosynthetic process
GO:0043066	negative regulation of apoptosis
GO:0046318	negative regulation of glucosylceramide biosynthetic process
GO:0050995	negative regulation of lipid catabolic process
GO:0032007	negative regulation of TOR signaling pathway
GO:0010508	positive regulation of autophagy
GO:0008284	positive regulation of cell proliferation
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0010628	positive regulation of gene expression
GO:0045821	positive regulation of glycolysis
GO:0006468	protein amino acid phosphorylation
GO:0051291	protein heterooligomerization
GO:0042752	regulation of circadian rhythm
GO:0006355	regulation of transcription, DNA-dependent
GO:0060627	regulation of vesicle-mediated transport
GO:0014823	response to activity
GO:0031000	response to caffeine
GO:0001666	response to hypoxia
GO:0006950	response to stress
GO:0048511	rhythmic process
GO:0007165	signal transduction
GO:0006351	transcription, DNA-dependent
GO:0016055	Wnt receptor signaling pathway

Cellular Component

GO:0031588	AMP-activated protein kinase complex
GO:0016324	apical plasma membrane
GO:0005829	cytosol
GO:0005622	intracellular
GO:0005634	nucleus

Molecular Function

GO:0004679	AMP-activated protein kinase activity
GO:0005524	ATP binding
GO:0004691	cAMP-dependent protein kinase activity
GO:0003682	chromatin binding
GO:0035174	histone serine kinase activity
GO:0019900	kinase binding
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0004672	protein kinase activity
GO:0050321	tau-protein kinase activity
GO:0050405	[acetyl-CoA carboxylase] kinase activity
GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

protein kinase, AMP-activated, alpha 1 catalytic subunit

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function