hypoxia inducible factor 1, alpha subunit inhibitor

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Synonym

Factor inhibiting HIF-1, FIH1, Hypoxia-inducible factor asparagine hydroxylase, HIF1AN, DKFZp762F1811, FLJ22027, Hypoxia-inducible factor 1 alpha inhibitor, FIH-1, FLJ20615

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:27.30 cerebellum:37.80 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:29.40 artery/aorta:30 vein:- lymphnode:10.10 peripheral blood:- spleen:18.90 thymus:12.90 bone marrow:59 adipose:40.30 bone:- skin:33.60
GeneChip cerebrum:6.38 cerebellum:5.89 brain stem:6.60 corpus callosum/glia:6.37 pineal gland:- peripheral nerve:6.09 spine:6.22 retina:- eye:- artery/aorta:6.29 vein:6.32 lymphnode:6.13 peripheral blood:- spleen:6.04 thymus:6.14 bone marrow:6.15 adipose:5.92 bone:- skin:5.97
CAGE cerebrum:3.52 cerebellum:- brain stem:3.64 corpus callosum/glia:3.59 pineal gland:3.65 peripheral nerve:- spine:3.27 retina:- eye:- artery/aorta:3.65 vein:3.39 lymphnode:3.55 peripheral blood:- spleen:3.32 thymus:3.54 bone marrow:- adipose:3.19 bone:- skin:-
RNA-seq cerebrum:2.48 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.11 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.56 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:7.30 prostate:11.30 ovary:74.50 testis:13 heart:12.80 muscle:20.10 esophagus:- stomach:21.20 intestine:- colon:33.90     liver/hepato:-        lung:19.60    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:53.30 breast:55.80 salivary:-
GeneChip uterus:6.11 placenta:6.03 prostate:5.93 ovary:6.19 testis:6.68 heart:6.55 muscle:7.40 esophagus:6.15 stomach:6.02 intestine:6.42 colon:6.41 liver/hepato:6.13 lung:6.12 bladder:- kidney:6.35 pituitary:6.21 thyroid/parathyroid:5.84 adrenal gland:6.39 pancreas:6.08 breast:6.08 salivary:6.16
CAGE uterus:3.44 placenta:3.37 prostate:3.37 ovary:3.27 testis:4.04 heart:3.54 muscle:4.29 esophagus:3.22 stomach:- intestine:3.23 colon:3.50     liver/hepato:2.81    lung:3.28 bladder:3.10 kidney:3.19 pituitary:3.52 thyroid/parathyroid:3.01 adrenal gland:- pancreas:3.69 breast:3.76 salivary:3.34
RNA-seq uterus:- placenta:- prostate:3.46 ovary:3.64 testis:3.90 heart:3.01 muscle:3.99 esophagus:- stomach:- intestine:- colon:3.08     liver/hepato:1.93        lung:2.03    bladder:- kidney:3.03 pituitary:- thyroid/parathyroid:3.40 adrenal gland:2.80 pancreas:- breast:3.09 salivary:-

Gene Information

IDs

Refseq ID NM_017902
Gene ID 55662
Unigene ID Hs.500788
Probe set ID 218525_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000166135
GTEx ID ENSG00000166135

Orthologous Gene

Mouse[1]  NM_176958
Rat[1]  NM_001113749

Chromosomal Region

10q24.31  [102,288,829  -  102,309,763]

Gene Family (Interpro ID)

IPR003347  Transcription factor jumonji/aspartyl beta-hydroxylase

Link to Pubmed  (Pubmed ID)

11641274
11823643
11959990
12042299
12080085
12215170
12432100
12446723
12477932
12482756
14701857
14702039
14734545
15280364
15489334
16189514
16385451
17003112
17135241
17244529
17382325
17573339
17636018
17682059
18096060
18280659
18299578
18398039
18611856
18676680
18927305
18936059
19060904
19074848
19134330
19170196
19245366
19322201
19401150
19615732
19625176
19692168
19696166
19726677
19940151
20145132
20453000
20720525
20727020
21069436
21139048
21177872
21251231
21443853
21732131
21808058
21890473
21906983
22002313
22532441
22645313
22797925
22891326
23000965
23351038
23362303
23606740
24100311
24337577

Gene Ontology  (GO ID)

Biological Process

GO:0071456  cellular response to hypoxia
GO:0045746  negative regulation of Notch signaling pathway
GO:0055114  oxidation reduction
GO:0042265  peptidyl-asparagine hydroxylation
GO:0042264  peptidyl-aspartic acid hydroxylation
GO:0045663  positive regulation of myoblast differentiation
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0031406  carboxylic acid binding
GO:0048037  cofactor binding
GO:0005506  iron ion binding
GO:0051059  NF-kappaB binding
GO:0005112  Notch binding
GO:0016706  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0016702  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019826  oxygen sensor activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0008270  zinc ion binding