tyrosyl-DNA phosphodiesterase 1

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Synonym

SCAN1, Tyrosyl-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, TDP1, MGC104252, FLJ11090

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:27.30 cerebellum:12.60 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:- retina:- eye:29.40 artery/aorta:60 vein:- lymphnode:70.80 peripheral blood:- spleen:75.60 thymus:25.80 bone marrow:39.40 adipose:- bone:25.60 skin:9.60
GeneChip cerebrum:5.09 cerebellum:5.11 brain stem:5.11 corpus callosum/glia:5.07 pineal gland:- peripheral nerve:4.97 spine:5.11 retina:- eye:- artery/aorta:5.13 vein:4.91 lymphnode:5.55 peripheral blood:- spleen:5.46 thymus:6.57 bone marrow:5.99 adipose:5.47 bone:- skin:5.41
CAGE cerebrum:2.18 cerebellum:- brain stem:1.90 corpus callosum/glia:2.06 pineal gland:2.15 peripheral nerve:- spine:1.93 retina:- eye:- artery/aorta:1.72 vein:2.11 lymphnode:2.64 peripheral blood:- spleen:2.36 thymus:3.14 bone marrow:- adipose:1.84 bone:- skin:-
RNA-seq cerebrum:0.41 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.92 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.48 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:58.30 prostate:- ovary:- testis:95.20 heart:76.60 muscle:- esophagus:685.60 stomach:- intestine:- colon:42.40     liver/hepato:-        lung:29.30    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:35.60 breast:18.60 salivary:-
GeneChip uterus:5.28 placenta:5.34 prostate:5.27 ovary:5.30 testis:7.19 heart:5.01 muscle:5.07 esophagus:5.48 stomach:5.20 intestine:5.30 colon:5.41 liver/hepato:5.08 lung:5.20 bladder:- kidney:5.09 pituitary:5.33 thyroid/parathyroid:5.06 adrenal gland:5.04 pancreas:5.25 breast:5.21 salivary:5.27
CAGE uterus:2.11 placenta:1.84 prostate:1.69 ovary:1.79 testis:3.34 heart:1.20 muscle:0.70 esophagus:2.01 stomach:- intestine:1.61 colon:1.57     liver/hepato:1.29    lung:1.62 bladder:1.89 kidney:1.90 pituitary:2.30 thyroid/parathyroid:1.28 adrenal gland:- pancreas:1.87 breast:1.16 salivary:2.01
RNA-seq uterus:- placenta:- prostate:0.46 ovary:0.15 testis:2.24 heart:0.21 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.58     liver/hepato:0.57        lung:0.80    bladder:- kidney:0.30 pituitary:- thyroid/parathyroid:0.10 adrenal gland:1.26 pancreas:- breast:0.42 salivary:-

Gene Information

IDs

Refseq ID NM_018319
Gene ID 55775
Unigene ID Hs.209945
Probe set ID 219715_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000042088
GTEx ID ENSG00000042088

Orthologous Gene

Mouse[1]  NM_028354
Rat [0]  

Chromosomal Region

14q32.11  [90,421,283  -  90,511,106]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8889548
10521354
11572945
11839309
12023295
12244316
12470949
12477932
12508121
12618186
14702039
14761185
15111055
15248776
15489334
15494395
15647511
15744309
15811850
15920477
16141202
16775218
16935573
17081983
17118488
17478428
17576665
17600775
17707402
17948061
18270339
18347181
19471022
19505854
19604089
19851285
20009512
20097655
20301284
21041670
21139048
21252943
21276450
21628532
21906983
22155078
22375014
22415824
22939629
23536040
23852793
23913164
24183900
24250222
24335147

Gene Ontology  (GO ID)

Biological Process

GO:0008219  cell death
GO:0006281  DNA repair
GO:0006302  double-strand break repair
GO:0000012  single strand break repair

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0017005  3'-tyrosyl-DNA phosphodiesterase activity
GO:0003690  double-stranded DNA binding
GO:0004527  exonuclease activity
GO:0005515  protein binding
GO:0003697  single-stranded DNA binding