protein tyrosine phosphatase, non-receptor type 2

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Synonym

TCELLPTP, TCPTP, protein tyrosine phosphatase, non-receptor type 2, Tyrosine-protein phosphatase non-receptor type 2, TC-PTP, PTPT, PTPN2, T-cell protein-tyrosine phosphatase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:2.66 cerebellum:2.96 brain stem:2.62 corpus callosum/glia:2.72 pineal gland:- peripheral nerve:2.57 spine:2.61 retina:- eye:- artery/aorta:2.57 vein:2.64 lymphnode:2.85 peripheral blood:- spleen:3.04 thymus:5.99 bone marrow:2.81 adipose:2.53 bone:- skin:2.59
CAGE cerebrum:3.31 cerebellum:- brain stem:3.10 corpus callosum/glia:2.75 pineal gland:3.97 peripheral nerve:- spine:4.04 retina:- eye:- artery/aorta:3.23 vein:3.96 lymphnode:3.88 peripheral blood:- spleen:3.84 thymus:4.64 bone marrow:- adipose:3.25 bone:- skin:-
RNA-seq cerebrum:1.43 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.11 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:2.77 placenta:2.62 prostate:2.81 ovary:2.74 testis:2.64 heart:2.56 muscle:2.56 esophagus:2.60 stomach:2.62 intestine:2.62 colon:2.62 liver/hepato:2.77 lung:2.78 bladder:- kidney:2.62 pituitary:2.76 thyroid/parathyroid:2.76 adrenal gland:2.63 pancreas:2.56 breast:2.68 salivary:2.54
CAGE uterus:3.02 placenta:3.21 prostate:3.23 ovary:3.33 testis:3.00 heart:3.28 muscle:2.91 esophagus:2.93 stomach:- intestine:3.17 colon:3.11     liver/hepato:3.49    lung:3.68 bladder:3.31 kidney:2.93 pituitary:3.89 thyroid/parathyroid:3.11 adrenal gland:- pancreas:3.59 breast:3.75 salivary:2.95
RNA-seq uterus:- placenta:- prostate:1.10 ovary:1.82 testis:1.82 heart:0.68 muscle:0.18 esophagus:- stomach:- intestine:- colon:0.64     liver/hepato:1.30        lung:1.57    bladder:- kidney:1.58 pituitary:- thyroid/parathyroid:1.82 adrenal gland:1.93 pancreas:- breast:1.06 salivary:-

Gene Information

IDs

Refseq ID NM_002828
Gene ID 5771
Unigene ID -
Probe set ID 204935_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000175354
GTEx ID ENSG00000175354

Orthologous Gene

Mouse[4]  NM_001127177, NM_008977
Rat [0]  

Chromosomal Region

18p11.21  [12,785,477  -  12,884,337]

Gene Family (Interpro ID)

IPR000242  Protein-tyrosine phosphatase, receptor/non-receptor type

Link to Pubmed  (Pubmed ID)

1731319
1849097
2164224
2546150
7593185
8125298
8325634
9261175
9488479
10488121
10940933
11907034
11909529
12138178
12171910
12359225
12459463
12477932
12612081
12847239
12907755
14600148
14966296
15030318
15192089
15489334
15509512
15539083
15588985
15592458
15632081
15696169
15778465
16293614
16344560
16595549
17207965
17210636
17554260
17554261
17554300
18438405
18519826
18587394
18593762
18819921
18840653
18936107
18948751
18978792
19073967
19171783
19174780
19240061
19264985
19336676
19422935
19430480
19565500
19615732
19755676
19760754
19818778
19861958
19898481
19922411
19951419
20059965
20088380
20190752
20203524
20222910
20379614
20403149
20473312
20689057
20886065
20940300
20962850
21072187
21102463
21115548
21179116
21220691
21246196
21300955
21383967
21551237
21791476
21829393
21876762
21906983
21984578
21987459
22021207
22105363
22233524
22294642
22377701
22404968
22426692
22446963
22457781
22671594
22671596
22939629
22960018
22960999
23124138
23128233
23166300
23328081
23454379
23518806
23579275
23824909
23840476
24022492
24040033
24250222
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0030183  B cell differentiation
GO:0019221  cytokine-mediated signaling pathway
GO:0030218  erythrocyte differentiation
GO:0042593  glucose homeostasis
GO:0008286  insulin receptor signaling pathway
GO:0060333  interferon-gamma-mediated signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0050922  negative regulation of chemotaxis
GO:0042059  negative regulation of epidermal growth factor receptor signaling pathway
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0050728  negative regulation of inflammatory response
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0060336  negative regulation of interferon-gamma-mediated signaling pathway
GO:0070104  negative regulation of interleukin-6-mediated signaling pathway
GO:0010888  negative regulation of lipid storage
GO:0045650  negative regulation of macrophage differentiation
GO:0050860  negative regulation of T cell receptor signaling pathway
GO:0010804  negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0060339  negative regulation of type I interferon-mediated signaling pathway
GO:0042512  negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518  negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524  negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527  negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0045722  positive regulation of gluconeogenesis
GO:0060334  regulation of interferon-gamma-mediated signaling pathway
GO:0030217  T cell differentiation

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0005793  ER-Golgi intermediate compartment
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005178  integrin binding
GO:0004726  non-membrane spanning protein tyrosine phosphatase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004725  protein tyrosine phosphatase activity
GO:0030971  receptor tyrosine kinase binding
GO:0019905  syntaxin binding