NLR family, CARD domain containing 4

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Synonym

Clan protein, Caspase recruitment domain-containing protein 12, CLAN1, CLANB, CLANA, IPAF, CLAN, CARD, LRR, and NACHT-containing protein, Ice protease-activating factor, CLANC, Ipaf, UNQ6189/PRO20215, CARD12, CLAND, caspase recruitment domain family, member 12, ipaf

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:91.10 spleen:- thymus:25.80 bone marrow:19.70 adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:0.61 cerebellum:- brain stem:1.32 corpus callosum/glia:0.96 pineal gland:0.71 peripheral nerve:- spine:1.51 retina:- eye:- artery/aorta:0.95 vein:1.53 lymphnode:1.63 peripheral blood:- spleen:2.89 thymus:0.74 bone marrow:- adipose:2.12 bone:- skin:-
RNA-seq cerebrum:0.26 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.61 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:- prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip nodata
CAGE uterus:0.40 placenta:0.88 prostate:0.62 ovary:0.72 testis:0.52 heart:0.92 muscle:0.13 esophagus:0.40 stomach:- intestine:0.84 colon:0.64     liver/hepato:0.90    lung:1.95 bladder:0.33 kidney:0.95 pituitary:0.72 thyroid/parathyroid:0.45 adrenal gland:- pancreas:0.58 breast:0 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.00 testis:0.00 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.28     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_021209
Gene ID 58484
Unigene ID Hs.574741
Probe set ID -
Ensembl ID ENSG00000091106
GTEx ID ENSG00000091106

Orthologous Gene

Mouse[1]  NM_001033367
Rat[1]  NM_001033367

Chromosomal Region

2p22.3  [32,449,522  -  32,490,923]

Gene Family (Interpro ID)

IPR001315  Caspase Recruitment
IPR011029  DEATH-like

Link to Pubmed  (Pubmed ID)

11374873
11390368
11472070
12477932
12545166
12646168
12975309
14702039
15030775
15107016
15174051
15489334
15528373
15580302
15882992
16817903
17418785
17620097
18453601
20085538
20349122
21918512
22227487
22547706
23012363
23215645
24182552

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0002218  activation of innate immune response
GO:0042742  defense response to bacterium
GO:0016045  detection of bacterium
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0050702  interleukin-1 beta secretion
GO:0043065  positive regulation of apoptosis
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0051260  protein homooligomerization
GO:0070269  pyroptosis

Cellular Component

GO:0005829  cytosol
GO:0005622  intracellular

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity