RAB27B, member RAS oncogene family

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Synonym

RAB27B, member RAS oncogene family, C25KG, Ras-related protein Rab-27B, RAB27B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:224.60 retina:- eye:17.60 artery/aorta:- vein:- lymphnode:- peripheral blood:36.40 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:3.29 cerebellum:3.28 brain stem:3.23 corpus callosum/glia:3.31 pineal gland:- peripheral nerve:3.01 spine:3.15 retina:- eye:- artery/aorta:3.16 vein:3.58 lymphnode:3.21 peripheral blood:- spleen:3.07 thymus:3.32 bone marrow:3.34 adipose:3.32 bone:- skin:3.68
CAGE cerebrum:0.68 cerebellum:- brain stem:0.82 corpus callosum/glia:0.43 pineal gland:0.48 peripheral nerve:- spine:0.84 retina:- eye:- artery/aorta:1.03 vein:0.88 lymphnode:1.87 peripheral blood:- spleen:2.04 thymus:0.74 bone marrow:- adipose:0.84 bone:- skin:-
RNA-seq cerebrum:2.63 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.47 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.14 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:10.90 prostate:56.30 ovary:- testis:17.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:31.70        lung:48.90    bladder:- kidney:10.40 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:55.80 salivary:-
GeneChip uterus:3.33 placenta:3.89 prostate:4.08 ovary:3.36 testis:4.63 heart:3.34 muscle:3.36 esophagus:3.87 stomach:3.55 intestine:3.39 colon:3.44 liver/hepato:3.21 lung:3.34 bladder:- kidney:3.04 pituitary:2.99 thyroid/parathyroid:2.96 adrenal gland:2.91 pancreas:3.86 breast:3.48 salivary:3.47
CAGE uterus:1.65 placenta:2.12 prostate:3.50 ovary:0.42 testis:0.62 heart:0.83 muscle:0.30 esophagus:3.72 stomach:- intestine:2.47 colon:2.68     liver/hepato:0.96    lung:2.73 bladder:1.73 kidney:0.78 pituitary:0.58 thyroid/parathyroid:0.53 adrenal gland:- pancreas:2.76 breast:2.19 salivary:3.68
RNA-seq uterus:- placenta:- prostate:1.93 ovary:0.34 testis:0.91 heart:0.07 muscle:0 esophagus:- stomach:- intestine:- colon:0.64     liver/hepato:0.17        lung:1.76    bladder:- kidney:0.56 pituitary:- thyroid/parathyroid:0.04 adrenal gland:0.27 pancreas:- breast:1.10 salivary:-

Gene Information

IDs

Refseq ID NM_004163
Gene ID 5874
Unigene ID Hs.25318
Probe set ID 207017_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000041353
GTEx ID ENSG00000041353

Orthologous Gene

Mouse[4]  NM_001082553, NM_030554
Rat[1]  NM_053459, NM_030554

Chromosomal Region

18q21.2  [52,495,708  -  52,562,747]

Gene Family (Interpro ID)

IPR002041  Ran GTPase
IPR013753  Ras
IPR001806  Ras GTPase
IPR020849  Ras small GTPase
IPR003579  Ras small GTPase, Rab type
IPR005225  Small GTP-binding protein
IPR020851  Small GTPase
IPR003578  Small GTPase, Rho type

Link to Pubmed  (Pubmed ID)

1445946
2507536
8619474
9066979
9110174
11178108
11856727
11956164
11980908
12122117
12477932
12578829
12907454
14699162
15489334
16880209
18029348
18478159
19199708
19966785
20237496
20379614
20484105
20888820
21198862
21304180
22349512
23217148
23390068
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0045921  positive regulation of exocytosis
GO:0015031  protein transport
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0016324  apical plasma membrane
GO:0005795  Golgi stack
GO:0032585  multivesicular body membrane
GO:0030140  trans-Golgi network transport vesicle
GO:0042589  zymogen granule membrane

Molecular Function

GO:0019003  GDP binding
GO:0005525  GTP binding
GO:0003924  GTPase activity
GO:0019904  protein domain specific binding