RAS p21 protein activator 2

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Synonym

RASA2, GAP1M, Ras GTPase-activating protein 2, GAP1m, RASGAP, RAS p21 protein activator 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.33 cerebellum:4.41 brain stem:4.29 corpus callosum/glia:4.17 pineal gland:- peripheral nerve:4.64 spine:4.05 retina:- eye:- artery/aorta:4.49 vein:4.17 lymphnode:4.90 peripheral blood:- spleen:5.26 thymus:5.73 bone marrow:4.54 adipose:4.53 bone:- skin:4.52
CAGE cerebrum:3.21 cerebellum:- brain stem:3.09 corpus callosum/glia:3.01 pineal gland:3.35 peripheral nerve:- spine:3.40 retina:- eye:- artery/aorta:3.44 vein:3.87 lymphnode:3.97 peripheral blood:- spleen:3.90 thymus:3.90 bone marrow:- adipose:3.41 bone:- skin:-
RNA-seq cerebrum:1.41 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.48 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.68 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.97 placenta:3.93 prostate:4.83 ovary:4.81 testis:5.01 heart:4.36 muscle:4.07 esophagus:4.51 stomach:4.54 intestine:4.18 colon:4.13 liver/hepato:4.17 lung:4.34 bladder:- kidney:4.10 pituitary:4.42 thyroid/parathyroid:4.34 adrenal gland:4.32 pancreas:4.13 breast:4.70 salivary:4.44
CAGE uterus:3.71 placenta:3.30 prostate:3.28 ovary:3.08 testis:2.84 heart:2.69 muscle:2.47 esophagus:3.02 stomach:- intestine:3.31 colon:3.46     liver/hepato:2.25    lung:3.55 bladder:3.36 kidney:2.78 pituitary:3.35 thyroid/parathyroid:2.61 adrenal gland:- pancreas:2.71 breast:3.43 salivary:3.41
RNA-seq uterus:- placenta:- prostate:1.93 ovary:2.35 testis:2.19 heart:0.68 muscle:0.44 esophagus:- stomach:- intestine:- colon:1.38     liver/hepato:0.55        lung:1.85    bladder:- kidney:0.99 pituitary:- thyroid/parathyroid:1.65 adrenal gland:2.02 pancreas:- breast:1.55 salivary:-

Gene Information

IDs

Refseq ID NM_006506
Gene ID 5922
Unigene ID -
Probe set ID 206636_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000155903
GTEx ID ENSG00000155903

Orthologous Gene

Mouse[1]  NM_053268
Rat[1]  NM_001105724

Chromosomal Region

3q23  [141,205,889  -  141,334,184]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein
IPR001849  Pleckstrin homology
IPR001936  Ras GTPase-activating protein
IPR008936  Rho GTPase activation protein

Link to Pubmed  (Pubmed ID)

8699317
8812506
8917095
9382842
9796816
10074452
14530271
18029348
21139048
22210626
23222517
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0046580  negative regulation of Ras protein signal transduction
GO:0032320  positive regulation of Ras GTPase activity
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0043231  intracellular membrane-bounded organelle
GO:0031235  intrinsic to internal side of plasma membrane
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0046872  metal ion binding
GO:0005543  phospholipid binding
GO:0005099  Ras GTPase activator activity