single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

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Synonym

TIR8, MGC110992, UNQ301/PRO342, Single Ig IL-1R-related molecule, Toll/interleukin-1 receptor 8, Single Ig IL-1-related receptor, SIGIRR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:82.30 artery/aorta:30 vein:66.60 lymphnode:161.80 peripheral blood:145.70 spleen:56.70 thymus:38.70 bone marrow:78.70 adipose:80.70 bone:51.20 skin:19.20
GeneChip cerebrum:5.68 cerebellum:4.95 brain stem:6 corpus callosum/glia:5.94 pineal gland:- peripheral nerve:6.65 spine:6.19 retina:- eye:- artery/aorta:6.21 vein:6.02 lymphnode:7.08 peripheral blood:- spleen:7.63 thymus:6.60 bone marrow:5.77 adipose:6.25 bone:- skin:5.88
CAGE cerebrum:2.73 cerebellum:- brain stem:3.23 corpus callosum/glia:3.11 pineal gland:2.11 peripheral nerve:- spine:3.19 retina:- eye:- artery/aorta:3.15 vein:3.51 lymphnode:3.73 peripheral blood:- spleen:3.24 thymus:3.13 bone marrow:- adipose:3.17 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.40 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:14.60 prostate:33.80 ovary:37.30 testis:17.30 heart:- muscle:- esophagus:342.80 stomach:42.50 intestine:32.40 colon:67.80     liver/hepato:63.30        lung:44    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:8.90 breast:- salivary:-
GeneChip uterus:5.95 placenta:5.27 prostate:6.26 ovary:6.14 testis:5.55 heart:6.13 muscle:5.32 esophagus:5.85 stomach:6.45 intestine:6.39 colon:6.68 liver/hepato:7.76 lung:6.92 bladder:- kidney:7.47 pituitary:5.57 thyroid/parathyroid:6.35 adrenal gland:5.46 pancreas:5.78 breast:6.28 salivary:6.64
CAGE uterus:3.21 placenta:2.45 prostate:3.31 ovary:2.99 testis:2.95 heart:3.19 muscle:2.10 esophagus:3.29 stomach:- intestine:3.74 colon:3.76     liver/hepato:4.53    lung:3.27 bladder:3.16 kidney:3.74 pituitary:2.49 thyroid/parathyroid:3.04 adrenal gland:- pancreas:3.40 breast:3.66 salivary:3.34
RNA-seq uterus:- placenta:- prostate:0.82 ovary:0.00 testis:0.00 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.72     liver/hepato:0.00        lung:0.00    bladder:- kidney:1.62 pituitary:- thyroid/parathyroid:0.83 adrenal gland:0.49 pancreas:- breast:0.49 salivary:-

Gene Information

IDs

Refseq ID NM_001135053
Gene ID 59307
Unigene ID Hs.501624
Probe set ID 218921_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000185187
GTEx ID ENSG00000185187

Orthologous Gene

Mouse[1]  NM_023059
Rat[1]  NM_001024887

Chromosomal Region

11p15.5  [405,716  -  417,455]

Gene Family (Interpro ID)

IPR004075  Interleukin-1 receptor, type I/Toll precursor
IPR000157  Toll-Interleukin receptor

Link to Pubmed  (Pubmed ID)

10346978
11022119
12477932
12925853
12975309
14702039
14715412
15489334
15866876
16169070
16344560
16432636
19200604
19699681
20130217
20331378
20364327
20506350
21048031
21077278
21187075
21832049
21890473
22223854
22634523
22952899

Gene Ontology  (GO ID)

Biological Process

GO:0006953  acute-phase response
GO:0045079  negative regulation of chemokine biosynthetic process
GO:0001960  negative regulation of cytokine-mediated signaling pathway
GO:0031665  negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0043433  negative regulation of transcription factor activity
GO:0007165  signal transduction

Cellular Component

GO:0016021  integral to membrane
GO:0016020  membrane

Molecular Function

GO:0005515  protein binding