chemokine (C-C motif) ligand 21

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Synonym

chemokine (C-C motif) ligand 21, Secondary lymphoid-tissue chemokine, MGC34555, 6Ckine, TCA4, SLC, exodus-2, Small inducible cytokine A21 precursor, ECL, CKb9, UNQ784/PRO1600, Beta chemokine exodus-2, CCL21, SCYA21

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.60 cerebellum:5.46 brain stem:5.61 corpus callosum/glia:5.33 pineal gland:- peripheral nerve:5.37 spine:5.35 retina:- eye:- artery/aorta:7.22 vein:6.71 lymphnode:10.61 peripheral blood:- spleen:8.40 thymus:5.80 bone marrow:5.62 adipose:8.39 bone:- skin:6.97
CAGE cerebrum:0.08 cerebellum:- brain stem:0.07 corpus callosum/glia:0.70 pineal gland:0 peripheral nerve:- spine:0.13 retina:- eye:- artery/aorta:4.49 vein:7.62 lymphnode:7.71 peripheral blood:- spleen:5.64 thymus:2.72 bone marrow:- adipose:3.00 bone:- skin:-
RNA-seq cerebrum:0.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:10.83 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.69 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.83 placenta:5.26 prostate:6.06 ovary:7.23 testis:5.40 heart:6.98 muscle:6.21 esophagus:6.90 stomach:7.25 intestine:7.47 colon:8.15 liver/hepato:6.44 lung:7.57 bladder:- kidney:5.68 pituitary:5.46 thyroid/parathyroid:8.29 adrenal gland:6.33 pancreas:6.45 breast:7.13 salivary:6.04
CAGE uterus:4.93 placenta:4.01 prostate:4.36 ovary:4.69 testis:3.52 heart:4.62 muscle:3.17 esophagus:6.47 stomach:- intestine:5.18 colon:5.33     liver/hepato:3.64    lung:5.37 bladder:4.84 kidney:5.01 pituitary:0.71 thyroid/parathyroid:5.91 adrenal gland:- pancreas:3.20 breast:2.53 salivary:4.94
RNA-seq uterus:- placenta:- prostate:5.84 ovary:4.52 testis:4.64 heart:3.00 muscle:2.20 esophagus:- stomach:- intestine:- colon:5.20     liver/hepato:3.39        lung:6.78    bladder:- kidney:3.68 pituitary:- thyroid/parathyroid:4.77 adrenal gland:10.67 pancreas:- breast:3.36 salivary:-

Gene Information

IDs

Refseq ID NM_002989
Gene ID 6366
Unigene ID -
Probe set ID 204606_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000137077
GTEx ID ENSG00000137077

Orthologous Gene

Mouse[3]  NM_001193667, NM_011124, NM_001193668, NM_001193666, NM_011335, NM_023052
Rat [0]  

Chromosomal Region

9p13.3  [34,709,002  -  34,710,121]

Gene Family (Interpro ID)

IPR001811  Small chemokine, interleukin-8-like

Link to Pubmed  (Pubmed ID)

9235955
9257816
9300671
9419363
9507024
9585422
10201891
10706668
10861057
11083865
11242036
11929789
11943728
11970971
12066416
12393410
12393730
12477932
12651610
12707342
12729902
12847218
12975309
14517790
14592837
14667884
14709406
14726633
14726959
14978072
15059845
15073111
15342556
15461605
15489334
15546958
15569314
15674360
15778365
15863780
15934082
15972662
16671092
16713569
16887149
16904643
17331965
17460916
17469160
17474076
17495955
17881634
17890452
17949547
17982129
18240029
18354239
18577758
18757429
18794853
18802075
19082456
19110536
19180477
19624896
19644859
19674979
19750015
19832038
19847900
20049410
20219786
20233754
20439292
20444755
20453842
20461788
20488224
20488940
20498205
20739459
20797713
20889506
21464944
21586211
21666055
21698152
21900206
21972019
22221265
22392503
22427939
22438908
22468089
22619482
22884357
22976543
23498789
23760102
23764550
24035972
24111618
24383579
24556356

Gene Ontology  (GO ID)

Biological Process

GO:0032862  activation of Rho GTPase activity
GO:0048469  cell maturation
GO:0007267  cell-cell signaling
GO:0002407  dendritic cell chemotaxis
GO:0001768  establishment of T cell polarity
GO:0001771  formation of immunological synapse
GO:0006955  immune response
GO:0006954  inflammatory response
GO:0030838  positive regulation of actin filament polymerization
GO:0033630  positive regulation of cell adhesion mediated by integrin
GO:0001954  positive regulation of cell-matrix adhesion
GO:0050921  positive regulation of chemotaxis
GO:0002606  positive regulation of dendritic cell antigen processing and presentation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0051491  positive regulation of filopodium assembly
GO:0010560  positive regulation of glycoprotein biosynthetic process
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046330  positive regulation of JNK cascade
GO:0090023  positive regulation of neutrophil chemotaxis
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0045860  positive regulation of protein kinase activity
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0031274  positive regulation of pseudopodium assembly
GO:0048260  positive regulation of receptor-mediated endocytosis
GO:0051209  release of sequestered calcium ion into cytosol
GO:0034695  response to prostaglandin E stimulus
GO:0031529  ruffle organization
GO:0031295  T cell costimulation

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space

Molecular Function

GO:0031732  CCR7 chemokine receptor binding
GO:0008009  chemokine activity