sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

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Synonym

Sema4, Semaphorin-3F precursor, sema IV, SEMAK, SEMA3F, SEMA-IV, Semaphorin IV, SEMA4, Sema III/F, Sema IV

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:70.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:80.70 bone:- skin:67.20
GeneChip cerebrum:3.17 cerebellum:3.06 brain stem:3.21 corpus callosum/glia:3.11 pineal gland:- peripheral nerve:3.16 spine:3.03 retina:- eye:- artery/aorta:3.77 vein:3.40 lymphnode:3.42 peripheral blood:- spleen:3.55 thymus:3.17 bone marrow:3.29 adipose:3.59 bone:- skin:4
CAGE cerebrum:2.24 cerebellum:- brain stem:2.42 corpus callosum/glia:2.26 pineal gland:3.99 peripheral nerve:- spine:2.20 retina:- eye:- artery/aorta:3.72 vein:3.37 lymphnode:3.53 peripheral blood:- spleen:5.08 thymus:2.14 bone marrow:- adipose:3.98 bone:- skin:-
RNA-seq cerebrum:0.97 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.54 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.37 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:10.90 prostate:90.10 ovary:- testis:- heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:24.40    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip uterus:3.38 placenta:3.37 prostate:3.87 ovary:3.55 testis:3.12 heart:3.35 muscle:3.26 esophagus:4.61 stomach:3.48 intestine:3.37 colon:3.29 liver/hepato:3.09 lung:3.82 bladder:- kidney:3.34 pituitary:3.27 thyroid/parathyroid:3.67 adrenal gland:3.29 pancreas:3.20 breast:3.42 salivary:3.46
CAGE uterus:3.54 placenta:4.36 prostate:3.73 ovary:2.89 testis:2.27 heart:3.71 muscle:2.88 esophagus:4.76 stomach:- intestine:3.33 colon:3.15     liver/hepato:2.60    lung:4.11 bladder:3.65 kidney:3.78 pituitary:2.86 thyroid/parathyroid:3.64 adrenal gland:- pancreas:2.08 breast:4.39 salivary:3.65
RNA-seq uterus:- placenta:- prostate:3.15 ovary:1.71 testis:1.54 heart:1.65 muscle:1.11 esophagus:- stomach:- intestine:- colon:2.89     liver/hepato:1.06        lung:4.77    bladder:- kidney:3.31 pituitary:- thyroid/parathyroid:2.70 adrenal gland:2.82 pancreas:- breast:2.02 salivary:-

Gene Information

IDs

Refseq ID NM_004186
Gene ID 6405
Unigene ID Hs.32981
Probe set ID 206832_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000001617
GTEx ID ENSG00000001617

Orthologous Gene

Mouse[2]  NM_011349
Rat[1]  NM_001108185

Chromosomal Region

3p21.31  [50,192,478  -  50,226,508]

Gene Family (Interpro ID)

IPR003659  Plexin/semaphorin/integrin
IPR001627  Semaphorin/CD100 antigen
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

7566098
7637782
8269517
8402908
8633026
8649831
8786119
8889548
9331348
9883722
10095013
10702410
12477932
12659673
12845630
15489334
15520858
15550623
15814794
15862967
15967098
16169070
17308083
17569671
17693432
18476556
18660502
18818766
19177200
19657188
19683737
19790074
19851296
20036365
20124444
20198310
20198315
20388805
21349996
21610314
21963094
22093159
22350413
22431917
23314748
23603393
24079887

Gene Ontology  (GO ID)

Biological Process

GO:0048846  axon extension involved in axon guidance
GO:0007411  axon guidance
GO:0048843  negative regulation of axon extension involved in axon guidance
GO:0021675  nerve development
GO:0001755  neural crest cell migration
GO:0048485  sympathetic nervous system development

Cellular Component

GO:0005615  extracellular space
GO:0016020  membrane

Molecular Function

GO:0045499  chemorepellent activity
GO:0004872  receptor activity