solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

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Synonym

Low-affinity cationic amino acid transporter 2, SLC7A2, ATRC2, CAT-2, HCAT2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:237.30 eye:76.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:- bone marrow:- adipose:- bone:102.40 skin:62.40
GeneChip cerebrum:3.88 cerebellum:3.97 brain stem:3.82 corpus callosum/glia:3.92 pineal gland:- peripheral nerve:3.86 spine:3.99 retina:- eye:- artery/aorta:4.01 vein:3.90 lymphnode:3.77 peripheral blood:- spleen:3.83 thymus:3.97 bone marrow:3.84 adipose:3.85 bone:- skin:4.02
CAGE cerebrum:2.33 cerebellum:- brain stem:2.26 corpus callosum/glia:2.24 pineal gland:2.12 peripheral nerve:- spine:3.84 retina:- eye:- artery/aorta:3.04 vein:2.67 lymphnode:2.00 peripheral blood:- spleen:2.01 thymus:0.33 bone marrow:- adipose:3.03 bone:- skin:-
RNA-seq cerebrum:0.63 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.81 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.04 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:142.10 prostate:78.90 ovary:- testis:13 heart:76.60 muscle:100.50 esophagus:- stomach:21.20 intestine:32.40 colon:8.50     liver/hepato:168.90        lung:44    bladder:251.20 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:240.10 breast:102.20 salivary:-
GeneChip uterus:3.84 placenta:5.18 prostate:3.80 ovary:4.13 testis:4.19 heart:4 muscle:4.44 esophagus:3.79 stomach:3.84 intestine:4.23 colon:3.91 liver/hepato:4.12 lung:3.82 bladder:- kidney:3.94 pituitary:3.96 thyroid/parathyroid:3.83 adrenal gland:3.89 pancreas:5.34 breast:3.88 salivary:3.78
CAGE uterus:2.69 placenta:4.38 prostate:2.19 ovary:4.37 testis:3.32 heart:3.26 muscle:4.77 esophagus:2.28 stomach:- intestine:1.22 colon:1.83     liver/hepato:5.11    lung:2.55 bladder:2.51 kidney:2.32 pituitary:2.09 thyroid/parathyroid:2.67 adrenal gland:- pancreas:4.51 breast:4.03 salivary:1.00
RNA-seq uterus:- placenta:- prostate:2.87 ovary:4.61 testis:1.08 heart:0.91 muscle:2.86 esophagus:- stomach:- intestine:- colon:2.27     liver/hepato:1.74        lung:3.42    bladder:- kidney:2.92 pituitary:- thyroid/parathyroid:3.02 adrenal gland:2.82 pancreas:- breast:2.46 salivary:-

Gene Information

IDs

Refseq ID NM_001008539
Gene ID 6542
Unigene ID Hs.448520
Probe set ID 207626_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000003989
GTEx ID ENSG00000003989

Orthologous Gene

Mouse[6]  NM_001044740, NM_007514
Rat[2]  NM_001134686, NM_022619

Chromosomal Region

8p22  [17,354,597  -  17,428,082]

Gene Family (Interpro ID)

IPR002293  Amino acid/polyamine transporter I
IPR004755  Cationic amino acid transport permease
IPR015606  Cationic amino acid transporter

Link to Pubmed  (Pubmed ID)

8954799
9040790
9174363
10756096
11665818
12477932
12787129
15064952
15489334
16344560
18029348
18172665
18195088
20424473
20430034
20600019
20972266
21139048
21906983
21963094
21987572
22053931
22787143
22870827
24019517

Gene Ontology  (GO ID)

Biological Process

GO:0006865  amino acid transport
GO:0006520  cellular amino acid metabolic process
GO:0006811  ion transport
GO:0042116  macrophage activation
GO:0006809  nitric oxide biosynthetic process
GO:0002537  production of nitric oxide during acute inflammatory response
GO:0050727  regulation of inflammatory response
GO:0043030  regulation of macrophage activation
GO:0055085  transmembrane transport
GO:0006810  transport

Cellular Component

GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0015174  basic amino acid transmembrane transporter activity
GO:0005289  high affinity arginine transmembrane transporter activity
GO:0015189  L-lysine transmembrane transporter activity
GO:0000064  L-ornithine transmembrane transporter activity