bone morphogenetic protein receptor, type IA

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Synonym

bone morphogenetic protein receptor, type IA, BMP type-IA receptor, BMPRIA, BMP type 1a receptor, BMPR-1A, Activin receptor-like kinase 3, BMPR1a, BMP type-Ia receptor, BMP type-1a receptor, BMPR Ia, CD292, BMPR-Ia, BMPR 1A, ALK3, BMP type Ia receptor, Serine/threonine-protein kinase receptor R5, BMPR-1a, SKR5, ACVRLK3, BMPRIa, BMPR1A, BMP type-1A receptor, BMP type 1A receptor, ALK-3, BMPR IA, CD292 antigen, BMP type IA receptor, BMPR 1a

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.60 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:29.40 artery/aorta:60 vein:- lymphnode:40.40 peripheral blood:- spleen:- thymus:- bone marrow:59 adipose:40.30 bone:25.60 skin:67.20
GeneChip cerebrum:4.77 cerebellum:4.45 brain stem:4.73 corpus callosum/glia:4.68 pineal gland:- peripheral nerve:5.70 spine:5.82 retina:- eye:- artery/aorta:6.67 vein:6.39 lymphnode:4.48 peripheral blood:- spleen:4.15 thymus:3.83 bone marrow:3.23 adipose:5.83 bone:- skin:5.58
CAGE cerebrum:2.63 cerebellum:- brain stem:2.53 corpus callosum/glia:2.91 pineal gland:2.27 peripheral nerve:- spine:3.04 retina:- eye:- artery/aorta:3.02 vein:1.89 lymphnode:1.85 peripheral blood:- spleen:1.86 thymus:0.83 bone marrow:- adipose:2.41 bone:- skin:-
RNA-seq cerebrum:2.85 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.24 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.71 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:25.50 prostate:90.10 ovary:- testis:30.30 heart:12.80 muscle:40.20 esophagus:- stomach:106.20 intestine:- colon:93.30     liver/hepato:21.10        lung:58.70    bladder:125.60 kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:102.20 salivary:-
GeneChip uterus:6.38 placenta:4.77 prostate:6.97 ovary:6.07 testis:5.46 heart:5.69 muscle:6.39 esophagus:4.94 stomach:5.68 intestine:5.60 colon:5.37 liver/hepato:4.39 lung:5.05 bladder:- kidney:5.59 pituitary:5.80 thyroid/parathyroid:7.11 adrenal gland:5.17 pancreas:4.49 breast:6.11 salivary:6.60
CAGE uterus:3.36 placenta:1.96 prostate:2.87 ovary:3.22 testis:2.76 heart:2.47 muscle:2.28 esophagus:2.65 stomach:- intestine:2.55 colon:2.55     liver/hepato:1.84    lung:2.30 bladder:3.23 kidney:2.47 pituitary:3.02 thyroid/parathyroid:2.63 adrenal gland:- pancreas:2.71 breast:2.27 salivary:2.43
RNA-seq uterus:- placenta:- prostate:4.02 ovary:3.70 testis:3.42 heart:2.69 muscle:2.45 esophagus:- stomach:- intestine:- colon:3.71     liver/hepato:1.60        lung:3.24    bladder:- kidney:2.95 pituitary:- thyroid/parathyroid:4.07 adrenal gland:2.81 pancreas:- breast:3.51 salivary:-

Gene Information

IDs

Refseq ID NM_004329
Gene ID 657
Unigene ID Hs.524477
Probe set ID 213578_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000107779
GTEx ID ENSG00000107779

Orthologous Gene

Mouse[5]  NM_009758
Rat [0]  

Chromosomal Region

10q23.2  [88,516,396  -  88,684,945]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7644468
7791754
8006002
8397373
8592941
8605097
8702914
8707881
9136927
9389648
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9547239
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15064755
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22886282
22939624
22971142
23000965
23399955
23433720
23593444
23969729
24008158
24398041
24850914

Gene Ontology  (GO ID)

Biological Process

GO:0030509  BMP signaling pathway
GO:0051216  cartilage development
GO:0048589  developmental growth
GO:0009950  dorsal/ventral axis specification
GO:0007398  ectoderm development
GO:0042733  embryonic digit morphogenesis
GO:0048568  embryonic organ development
GO:0003272  endocardial cushion formation
GO:0060914  heart formation
GO:0035137  hindlimb morphogenesis
GO:0006955  immune response
GO:0001701  in utero embryonic development
GO:0048368  lateral mesoderm development
GO:0030324  lung development
GO:0048382  mesendoderm development
GO:0001707  mesoderm formation
GO:0001880  Mullerian duct regression
GO:0050768  negative regulation of neurogenesis
GO:0014032  neural crest cell development
GO:0021998  neural plate mediolateral pattern formation
GO:0042475  odontogenesis of dentine-containing tooth
GO:0060021  palate development
GO:0048352  paraxial mesoderm structural organization
GO:0021983  pituitary gland development
GO:0030501  positive regulation of bone mineralization
GO:0050679  positive regulation of epithelial cell proliferation
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0045669  positive regulation of osteoblast differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0048378  regulation of lateral mesodermal cell fate specification
GO:0001756  somitogenesis
GO:0019827  stem cell maintenance
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0005901  caveola
GO:0043025  cell soma
GO:0030425  dendrite
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004674  protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0005024  transforming growth factor beta receptor activity
GO:0004675  transmembrane receptor protein serine/threonine kinase activity