slit homolog 1 (Drosophila)

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Synonym

KIAA0813, slit1, slit (Drosophila) homolog 1, SLIT1, SLIL1, MEGF4, Multiple epidermal growth factor-like domains 4, Slit homolog 1 protein precursor, Slit-1, SLIT3, slit homolog 1 (Drosophila)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:116.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:35.30 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:90.20 bone marrow:- adipose:- bone:- skin:14.40
GeneChip cerebrum:3.96 cerebellum:3.84 brain stem:3.91 corpus callosum/glia:3.82 pineal gland:- peripheral nerve:3.62 spine:3.54 retina:- eye:- artery/aorta:3.58 vein:4.34 lymphnode:3.60 peripheral blood:- spleen:3.45 thymus:3.64 bone marrow:3.82 adipose:3.80 bone:- skin:3.85
CAGE cerebrum:2.39 cerebellum:- brain stem:0.80 corpus callosum/glia:1.29 pineal gland:0.36 peripheral nerve:- spine:1.43 retina:- eye:- artery/aorta:0 vein:1.03 lymphnode:0 peripheral blood:- spleen:0 thymus:2.07 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:2.33 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.11 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.08 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:7.30 prostate:- ovary:- testis:21.60 heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:19.60    bladder:- kidney:- pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.66 placenta:3.73 prostate:3.54 ovary:3.91 testis:3.64 heart:3.80 muscle:4.18 esophagus:3.83 stomach:3.62 intestine:3.83 colon:3.82 liver/hepato:3.77 lung:3.83 bladder:- kidney:3.72 pituitary:4.38 thyroid/parathyroid:3.53 adrenal gland:3.67 pancreas:4.34 breast:3.54 salivary:3.74
CAGE uterus:0 placenta:0 prostate:0.15 ovary:0.14 testis:0.21 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0.08     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:2.63 thyroid/parathyroid:0.12 adrenal gland:- pancreas:0.58 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.16 ovary:0.17 testis:0.25 heart:0.03 muscle:0.06 esophagus:- stomach:- intestine:- colon:0.15     liver/hepato:0.03        lung:0.10    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.02 adrenal gland:0.12 pancreas:- breast:0.11 salivary:-

Gene Information

IDs

Refseq ID NM_003061
Gene ID 6585
Unigene ID Hs.632082
Probe set ID 208221_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000187122
GTEx ID ENSG00000187122

Orthologous Gene

Mouse[1]  NM_015748
Rat [0]  

Chromosomal Region

10q24.1  [98,757,795  -  98,945,683]

Gene Family (Interpro ID)

IPR008985  Concanavalin A-like lectin/glucanase
IPR013320  Concanavalin A-like lectin/glucanase, subgroup
IPR006207  Cystine knot, C-terminal
IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3
IPR003645  Follistatin-like, N-terminal
IPR001791  Laminin G

Link to Pubmed  (Pubmed ID)

9693030
9813312
10364234
10432110
10433822
11748139
12107412
12141424
12168954
12200164
12477932
15207848
16162649
16385451
16713569
16840550
17062560
18029348
18829537
23251661
23382691

Gene Ontology  (GO ID)

Biological Process

GO:0048846  axon extension involved in axon guidance
GO:0007411  axon guidance
GO:0021834  chemorepulsion involved in embryonic olfactory bulb interneuron migration
GO:0033563  dorsal/ventral axon guidance
GO:0040023  establishment of nucleus localization
GO:0048853  forebrain morphogenesis
GO:0008045  motor axon guidance
GO:0050919  negative chemotaxis
GO:0048843  negative regulation of axon extension involved in axon guidance
GO:0051964  negative regulation of synaptogenesis
GO:0031290  retinal ganglion cell axon guidance
GO:0021510  spinal cord development

Cellular Component

GO:0005737  cytoplasm
GO:0005615  extracellular space

Molecular Function

GO:0005509  calcium ion binding
GO:0043395  heparan sulfate proteoglycan binding
GO:0048495  Roundabout binding