toll-like receptor 3

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Synonym

Toll-like receptor 3 precursor, CD283, TLR3, toll-like receptor 3, CD283 antigen

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:3.27 cerebellum:3.10 brain stem:3.30 corpus callosum/glia:3.61 pineal gland:- peripheral nerve:3.74 spine:3.58 retina:- eye:- artery/aorta:3.68 vein:3.56 lymphnode:3.46 peripheral blood:- spleen:3.87 thymus:3.43 bone marrow:3.34 adipose:4.22 bone:- skin:3.69
CAGE cerebrum:1.58 cerebellum:- brain stem:1.81 corpus callosum/glia:1.84 pineal gland:2.46 peripheral nerve:- spine:2.42 retina:- eye:- artery/aorta:2.41 vein:1.98 lymphnode:1.44 peripheral blood:- spleen:2.55 thymus:1.12 bone marrow:- adipose:3.05 bone:- skin:-
RNA-seq cerebrum:0.47 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.33 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.49 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.06 placenta:7.41 prostate:4.36 ovary:4.30 testis:4.04 heart:3.79 muscle:3.33 esophagus:4.10 stomach:3.96 intestine:4.13 colon:3.71 liver/hepato:3.96 lung:4.14 bladder:- kidney:4.05 pituitary:3.49 thyroid/parathyroid:3.90 adrenal gland:4.09 pancreas:3.85 breast:3.97 salivary:4.05
CAGE uterus:2.57 placenta:4.30 prostate:3.06 ovary:2.78 testis:1.35 heart:2.35 muscle:1.56 esophagus:3.13 stomach:- intestine:4.04 colon:2.76     liver/hepato:2.59    lung:3.33 bladder:2.63 kidney:3.05 pituitary:1.74 thyroid/parathyroid:2.97 adrenal gland:- pancreas:1.87 breast:2.99 salivary:2.31
RNA-seq uterus:- placenta:- prostate:2.46 ovary:2.10 testis:1.62 heart:1.02 muscle:0.57 esophagus:- stomach:- intestine:- colon:2.01     liver/hepato:0.96        lung:2.09    bladder:- kidney:2.38 pituitary:- thyroid/parathyroid:1.90 adrenal gland:1.67 pancreas:- breast:2.82 salivary:-

IDs

Refseq ID NM_003265
Gene ID 7098
Unigene ID -
Probe set ID 206271_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000164342
GTEx ID ENSG00000164342

Orthologous Gene

Mouse[2]  NM_126166
Rat[1]  NM_198791

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

9435236
10066798
10426995
10820283
11561001
11607032
11782555
12054664
12133979
12477932
12509442
12539043
12609980
12646618
12672806
12692549
12855817
14519765
14557267
14575692
14729660
14982987
14987294
15064760
15107846
15119015
15153468
15212709
15226270
15315972
15340161
15356140
15502848
15579900
15652398
15731229
15737993
15767394
15778392
15845391
15935884
15961631
15972671
16029432
16035096
16043704
16111635
16115877
16144834
16146574
16160153
16286015
16289658
16293707
16344560
16399790
16424203
16473828
16482523
16484229
16533755
16585585
16628196
16720699
16847112
16858407
16877304
16914605
16935934
16950283
17043099
17085778
17128265
17142768
17142772
17150911
17178723
17209042
17254392
17292969
17301562
17314152
17434873
17449641
17521732
17525119
17534115
17573354
17602875
17626075
17660379
17703412
17786279
17805015
17851256
17872438
17878161
17897319
17908959
17939877
17947455
17962643
17962701
17963596
17964520
17982077
18021446
18029758
18172197
18204787
18253710
18262679
18325643
18367536
18385087
18394314
18437017
18442983
18508883
18541719
18544529
18562533
18566014
18566393
18568036
18684960
18686608
18715647
18725521
18753640
18775079
18776324
18776592
18779317
18810425
18813073
18818748
18832709
18849495
18946062
18949355
18978302
18988918
19001446
19016379
19019335
19035519
19055649
19120481
19134117
19164128
19231996
19234180
19247444
19254290
19258923
19265130
19299748
19362356
19378782
19423540
19437550
19475618
19494321
19505919
19522763
19527514
19542247
19593445
19597128
19625408
19628747
19631980
19646728
19656899
19740627
19741468
19748983
19752565
19758322
19769802
19779021
19795416
19810822
19833099
19855253
19878930
19887600
19890046
19902255
19914718
19948350
19951172
19966137
19966777
20009359
20047764
20100933
20124101
20194452
20197609
20200155
20227302
20237496
20309865
20331378
20367642
20381870
20406303
20406964
20422193
20438785
20452482
20472559
20483009
20483744
20483774
20503287
20514466
20523058
20588308
20595247
20604744
20636339
20639488
20651983
20673868
20685081
20691286
20819670
20832341
20855885
20957750
20977567
20978888
21061265
21079408
21093032
21129170
21132533
21148036
21173679
21179282
21189260
21216866
21220319
21223583
21239167
21245912
21255094
21266579
21367858
21398612
21454254
21474651
21481769
21498625
21515789
21563279
21623661
21646299
21691053
21695056
21708001
21712495
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21730023
21735101
21802664
21829730
21839239
21843566
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21847628
21903422
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21931545
21949112
21952237
21960283
21978158
21990957
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22039520
22057682
22065573
22070917
22102050
22147891
22174453
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22205660
22260507
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22323545
22415225
22421267
22421964
22457005
22466005
22479513
22504413
22537752
22549436
22552940
22568929
22572822
22579623
22590509
22591330
22611194
22685032
22745793
22759966
22762377
22771581
22825813
22849850
22851595
22864531
22865861
22912896
22944378
22948160
22950839
22960172
22989785
23053995
23056170
23056470
23076446
23103873
23115281
23151015
23166319
23179584
23220997
23240626
23245579
23255072
23255358
23269203
23290562
23353987
23369718
23396947
23404408
23425350
23467704
23489702
23497334
23534905
23541683
23548575
23647955
23668802
23673618
23716670
23717201
23721942
23723066
23748743
23844087
23845419
23908180
23946637
23962979
24028589
24070541
24084648
24155891
24165198
24198284
24408902
24524192
24530528
24708416
24760149
24791904

Gene Ontology  (GO ID)

Biological Process

GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0071260  cellular response to mechanical stimulus
GO:0042742  defense response to bacterium
GO:0051607  defense response to virus
GO:0009597  detection of virus
GO:0006972  hyperosmotic response
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0007252  I-kappaB phosphorylation
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0045671  negative regulation of osteoclast differentiation
GO:0045080  positive regulation of chemokine biosynthetic process
GO:0032722  positive regulation of chemokine production
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050729  positive regulation of inflammatory response
GO:0045356  positive regulation of interferon-alpha biosynthetic process
GO:0045359  positive regulation of interferon-beta biosynthetic process
GO:0032728  positive regulation of interferon-beta production
GO:0045078  positive regulation of interferon-gamma biosynthetic process
GO:0032735  positive regulation of interleukin-12 production
GO:0032755  positive regulation of interleukin-6 production
GO:0032757  positive regulation of interleukin-8 production
GO:0046330  positive regulation of JNK cascade
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0034123  positive regulation of toll-like receptor signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032760  positive regulation of tumor necrosis factor production
GO:0034346  positive regulation of type III interferon production
GO:0043330  response to exogenous dsRNA
GO:0007165  signal transduction
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005789  endoplasmic reticulum membrane
GO:0010008  endosome membrane
GO:0000139  Golgi membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane

Molecular Function

GO:0003725  double-stranded RNA binding
GO:0004872  receptor activity
GO:0004888  transmembrane receptor activity