TXK tyrosine kinase

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Synonym

BTKL, TXK tyrosine kinase, TKL, Tyrosine-protein kinase TXK, TXK, MGC22473, RLK, PSCTK5, PTK4, PTK4 protein tyrosine kinase 4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:17.60 artery/aorta:- vein:- lymphnode:40.40 peripheral blood:36.40 spleen:18.90 thymus:25.80 bone marrow:39.40 adipose:- bone:12.80 skin:4.80
GeneChip cerebrum:2.79 cerebellum:2.76 brain stem:2.86 corpus callosum/glia:2.70 pineal gland:- peripheral nerve:3.09 spine:2.73 retina:- eye:- artery/aorta:2.83 vein:2.93 lymphnode:4.43 peripheral blood:- spleen:4.80 thymus:3.94 bone marrow:3.12 adipose:3.06 bone:- skin:2.95
CAGE cerebrum:0.04 cerebellum:- brain stem:0.19 corpus callosum/glia:0.07 pineal gland:0.14 peripheral nerve:- spine:0.13 retina:- eye:- artery/aorta:0.79 vein:2.94 lymphnode:3.58 peripheral blood:- spleen:3.05 thymus:2.67 bone marrow:- adipose:1.01 bone:- skin:-
RNA-seq cerebrum:0.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.25 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.11 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:87.40 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:42.50 intestine:- colon:-     liver/hepato:21.10        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:3.09 placenta:6.09 prostate:2.82 ovary:2.96 testis:2.85 heart:2.79 muscle:2.90 esophagus:2.91 stomach:2.89 intestine:2.82 colon:3.03 liver/hepato:3.10 lung:3.02 bladder:- kidney:2.95 pituitary:2.90 thyroid/parathyroid:2.97 adrenal gland:2.93 pancreas:3.03 breast:2.77 salivary:3.07
CAGE uterus:0.76 placenta:3.56 prostate:0.44 ovary:0.07 testis:0.16 heart:0.27 muscle:0.09 esophagus:1.01 stomach:- intestine:1.82 colon:1.16     liver/hepato:0.78    lung:1.68 bladder:0.87 kidney:1.01 pituitary:0 thyroid/parathyroid:0.23 adrenal gland:- pancreas:0 breast:1.16 salivary:0
RNA-seq uterus:- placenta:- prostate:0.47 ovary:0.34 testis:0.41 heart:0.26 muscle:0 esophagus:- stomach:- intestine:- colon:0.15     liver/hepato:0.37        lung:1.17    bladder:- kidney:0.91 pituitary:- thyroid/parathyroid:0.17 adrenal gland:1.90 pancreas:- breast:0.09 salivary:-

Gene Information

IDs

Refseq ID NM_003328
Gene ID 7294
Unigene ID Hs.479669
Probe set ID 206828_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000074966
GTEx ID ENSG00000074966

Orthologous Gene

Mouse[2]  NM_001122754, NM_013698
Rat[1]  NM_001024255, NM_013698

Chromosomal Region

4p12  [48,068,410  -  48,136,273]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7528718
7951233
8632917
8702662
9047237
9813138
10523612
10587356
10660534
11353545
11859127
12081135
12477932
14684750
15175272
16273093
16344560
16809408
18941202
19913121
20379614
20628086
20800603
22623531
23128233

Gene Ontology  (GO ID)

Biological Process

GO:0007202  activation of phospholipase C activity
GO:0002250  adaptive immune response
GO:0001816  cytokine production
GO:0032609  interferon-gamma production
GO:0032633  interleukin-4 production
GO:0001865  NK T cell differentiation
GO:0032729  positive regulation of interferon-gamma production
GO:0060335  positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0050852  T cell receptor signaling pathway
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity