tyrosine kinase 2

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Synonym

Non-receptor tyrosine-protein kinase TYK2, JTK1, tyrosine kinase 2, TYK2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:179

cerebellum:327.40

brain stem:-

corpus callosum/glia:175

pineal gland:445

peripheral nerve:92

spine:449.20

retina:-

eye:217.40

artery/aorta:60

vein:1399.60

lymphnode:535.90

peripheral blood:218.60

spleen:378.10

thymus:412.30

bone marrow:354.20

adipose:80.70

bone:179.10

skin:76.80

GeneChip

cerebrum:6.45

cerebellum:6.57

brain stem:6.40

corpus callosum/glia:6.82

pineal gland:-

peripheral nerve:6.61

spine:6.53

retina:-

eye:-

artery/aorta:6.58

vein:6.38

lymphnode:7.76

peripheral blood:-

spleen:7.77

thymus:7.60

bone marrow:7.24

adipose:7

bone:-

skin:6.76

CAGE

cerebrum:2.98

cerebellum:-

brain stem:2.93

corpus callosum/glia:3.26

pineal gland:3.20

peripheral nerve:-

spine:2.91

retina:-

eye:-

artery/aorta:2.91

vein:3.65

lymphnode:3.31

peripheral blood:-

spleen:3.15

thymus:3.32

bone marrow:-

adipose:2.64

bone:-

skin:-

RNA-seq

cerebrum:1.80

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.90

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.91

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:154.90

placenta:105.60

prostate:157.70

ovary:74.50

testis:173.10

heart:76.60

muscle:40.20

esophagus:-

stomach:21.20

intestine:194.40

colon:118.70

liver/hepato:73.90

lung:190.60

bladder:125.60

kidney:124.80

pituitary:-

thyroid/parathyroid:327.50

adrenal gland:-

pancreas:124.50

breast:92.90

salivary:328.40

GeneChip

uterus:6.70

placenta:6.37

prostate:6.49

ovary:6.68

testis:5.69

heart:6.65

muscle:6.34

esophagus:6.57

stomach:6.95

intestine:6.91

colon:6.85

liver/hepato:7.25

lung:7.35

bladder:-

kidney:7.17

pituitary:7.05

thyroid/parathyroid:7.08

adrenal gland:7

pancreas:6.35

breast:7.01

salivary:6.78

CAGE

uterus:2.86

placenta:2.42

prostate:2.66

ovary:2.61

testis:2.17

heart:2.86

muscle:2.64

esophagus:2.53

stomach:-

intestine:2.79

colon:3.15

liver/hepato:2.85

lung:3.21

bladder:2.22

kidney:2.64

pituitary:3.20

thyroid/parathyroid:2.72

adrenal gland:-

pancreas:2.86

breast:2.53

salivary:3.30

RNA-seq

uterus:-

placenta:-

prostate:2.80

ovary:3.38

testis:2.30

heart:2.20

muscle:3.16

esophagus:-

stomach:-

intestine:-

colon:2.58

liver/hepato:2.46

lung:2.82

bladder:-

kidney:2.99

pituitary:-

thyroid/parathyroid:3.06

adrenal gland:3.54

pancreas:-

breast:2.94

salivary:-

IDs

Refseq ID	NM_003331
Gene ID	7297
Unigene ID	Hs.75516
Probe set ID	205546_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000105397
GTEx ID	ENSG00000105397

Orthologous Gene

Mouse[2]	NM_001205312, NM_018793
Rat[2]	NM_001205312, NM_018793

IPR019749	Band 4.1 domain
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

GO:0019221	cytokine-mediated signaling pathway
GO:0006468	protein amino acid phosphorylation
GO:0007243	protein kinase cascade
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060337	type I interferon-mediated signaling pathway

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005829	cytosol
GO:0016020	membrane
GO:0005634	nucleus

GO:0005524	ATP binding
GO:0005131	growth hormone receptor binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0004713	protein tyrosine kinase activity

tyrosine kinase 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function