wingless-type MMTV integration site family, member 3

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Synonym

Proto-oncogene protein Wnt-3 precursor, MGC138323, MGC131950, MGC138321, INT4, WNT3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:4.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:20.20 peripheral blood:- spleen:- thymus:- bone marrow:39.40 adipose:- bone:- skin:-
GeneChip cerebrum:3.92 cerebellum:3.58 brain stem:4 corpus callosum/glia:3.65 pineal gland:- peripheral nerve:3.52 spine:3.57 retina:- eye:- artery/aorta:3.74 vein:4 lymphnode:3.67 peripheral blood:- spleen:3.42 thymus:3.42 bone marrow:3.63 adipose:3.95 bone:- skin:4.40
CAGE cerebrum:0.25 cerebellum:- brain stem:0.22 corpus callosum/glia:0.55 pineal gland:0.21 peripheral nerve:- spine:0.30 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0.23 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.71 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.16 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.21 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:8.70 heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:4.90    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:37.20 salivary:-
GeneChip uterus:3.50 placenta:3.33 prostate:3.59 ovary:3.56 testis:4.43 heart:3.49 muscle:3.76 esophagus:3.70 stomach:3.52 intestine:3.57 colon:3.73 liver/hepato:4.09 lung:3.66 bladder:- kidney:3.62 pituitary:3.89 thyroid/parathyroid:3.53 adrenal gland:3.61 pancreas:3.77 breast:4.22 salivary:3.77
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0.08 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.03 ovary:0.17 testis:1.95 heart:0.19 muscle:0.02 esophagus:- stomach:- intestine:- colon:0.30     liver/hepato:0.97        lung:0    bladder:- kidney:0.24 pituitary:- thyroid/parathyroid:0.54 adrenal gland:0.10 pancreas:- breast:0.13 salivary:-

Gene Information

IDs

Refseq ID NM_030753
Gene ID 7473
Unigene ID Hs.445884
Probe set ID 221455_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000108379
GTEx ID ENSG00000108379

Orthologous Gene

Mouse[1]  NM_009521
Rat[1]  NM_001105715

Chromosomal Region

17q21.31  [44,841,694  -  44,896,082]

Gene Family (Interpro ID)

IPR005816  Secreted growth factor Wnt protein
IPR005817  Wnt superfamily
IPR009141  Wnt-3 protein

Link to Pubmed  (Pubmed ID)

1846319
8167409
8168088
8244403
10431240
10557084
11076863
11604997
11788904
12477932
14872406
15293277
15489334
15588944
16890161
18044981
18309246
18313787
18413325
18563180
18606139
18787224
19365403
19421142
19724895
19851296
19863181
20190752
20198315
20301453
20672350
20709709
20890934
21314951
21789800
21812969
22070884
22112025
22288914
22451204
23071104
24162018
24344732

Gene Ontology  (GO ID)

Biological Process

GO:0009948  anterior/posterior axis specification
GO:0007411  axon guidance
GO:0045165  cell fate commitment
GO:0000902  cell morphogenesis
GO:0071300  cellular response to retinoic acid
GO:0009950  dorsal/ventral axis specification
GO:0035115  embryonic forelimb morphogenesis
GO:0035116  embryonic hindlimb morphogenesis
GO:0060323  head morphogenesis
GO:0060174  limb bud formation
GO:0001707  mesoderm formation
GO:0048843  negative regulation of axon extension involved in axon guidance
GO:0030182  neuron differentiation
GO:0048697  positive regulation of collateral sprouting in the absence of injury
GO:0010628  positive regulation of gene expression
GO:0060064  Spemann organizer formation at the anterior end of the primitive streak
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005788  endoplasmic reticulum lumen
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005796  Golgi lumen
GO:0005886  plasma membrane
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0005109  frizzled binding
GO:0019904  protein domain specific binding
GO:0048018  receptor agonist activity