X-ray repair complementing defective repair in Chinese hamster cells 4

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Synonym

XRCC4, X-ray repair cross-complementing protein 4, DNA-repair protein XRCC4

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:11.90

cerebellum:12.60

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:92

spine:-

retina:-

eye:11.80

artery/aorta:30

vein:-

lymphnode:40.40

peripheral blood:18.20

spleen:-

thymus:-

bone marrow:39.40

adipose:-

bone:12.80

skin:9.60

GeneChip

cerebrum:3.72

cerebellum:3.65

brain stem:3.91

corpus callosum/glia:3.88

pineal gland:-

peripheral nerve:3.93

spine:3.79

retina:-

eye:-

artery/aorta:4

vein:3.55

lymphnode:3.83

peripheral blood:-

spleen:3.87

thymus:4.48

bone marrow:4.15

adipose:3.82

bone:-

skin:3.84

CAGE

cerebrum:1.79

cerebellum:-

brain stem:1.99

corpus callosum/glia:1.71

pineal gland:1.98

peripheral nerve:-

spine:2.06

retina:-

eye:-

artery/aorta:1.33

vein:1.61

lymphnode:1.49

peripheral blood:-

spleen:2.30

thymus:2.47

bone marrow:-

adipose:1.97

bone:-

skin:-

RNA-seq

cerebrum:0.87

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:21.90

prostate:-

ovary:37.30

testis:47.60

heart:-

muscle:40.20

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:10.60

lung:-

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:27.90

salivary:-

GeneChip

uterus:3.83

placenta:3.60

prostate:3.81

ovary:3.89

testis:4.48

heart:3.79

muscle:3.54

esophagus:3.69

stomach:3.78

intestine:3.76

colon:3.73

liver/hepato:3.81

lung:3.79

bladder:-

kidney:3.71

pituitary:3.78

thyroid/parathyroid:3.61

adrenal gland:3.76

pancreas:3.74

breast:3.84

salivary:3.67

CAGE

uterus:1.67

placenta:1.96

prostate:1.42

ovary:1.53

testis:2.01

heart:1.84

muscle:1.14

esophagus:2.00

stomach:-

intestine:2.34

colon:1.33

liver/hepato:1.41

lung:1.96

bladder:1.58

kidney:2.11

pituitary:2.02

thyroid/parathyroid:1.59

adrenal gland:-

pancreas:0.58

breast:1.53

salivary:1.39

RNA-seq

uterus:-

placenta:-

prostate:0.83

ovary:0.49

testis:1.65

heart:0.00

muscle:0.62

esophagus:-

stomach:-

intestine:-

colon:0.75

liver/hepato:0.80

lung:0.81

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:1.12

pancreas:-

breast:1.15

salivary:-

IDs

Refseq ID	NM_003401
Gene ID	7518
Unigene ID	Hs.567359
Probe set ID	205071_x_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000152422
GTEx ID	ENSG00000152422

Orthologous Gene

Mouse[2]	NM_028012
Rat[1]	NM_001006999

Chromosomal Region

5q14.2 [82,373,317 - 82,652,548]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0071285	cellular response to lithium ion
GO:0007417	central nervous system development
GO:0051103	DNA ligation during DNA repair
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0033152	immunoglobulin V(D)J recombination
GO:0001701	in utero embryonic development
GO:0045190	isotype switching
GO:0043524	negative regulation of neuron apoptosis
GO:0048146	positive regulation of fibroblast proliferation
GO:0051351	positive regulation of ligase activity
GO:0050769	positive regulation of neurogenesis
GO:0002328	pro-B cell differentiation
GO:0010332	response to gamma radiation
GO:0010165	response to X-ray
GO:0033077	T cell differentiation in the thymus
GO:0016032	viral reproduction

Cellular Component

GO:0000793	condensed chromosome
GO:0005829	cytosol
GO:0032807	DNA ligase IV complex
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0070419	nonhomologous end joining complex
GO:0005654	nucleoplasm
GO:0005634	nucleus

Molecular Function

GO:0003677	DNA binding
GO:0016874	ligase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

X-ray repair complementing defective repair in Chinese hamster cells 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function