axin 1

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Synonym

AXIN, hAxin, Axis inhibition protein 1, MGC52315, Axin-1, AXIN1, axin 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:16.60 cerebellum:75.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:151.70 peripheral blood:18.20 spleen:18.90 thymus:- bone marrow:236.20 adipose:- bone:- skin:43.20
GeneChip cerebrum:6.54 cerebellum:6.65 brain stem:6.46 corpus callosum/glia:6.55 pineal gland:- peripheral nerve:6.40 spine:6.54 retina:- eye:- artery/aorta:6.78 vein:6.66 lymphnode:6.85 peripheral blood:- spleen:7.05 thymus:6.66 bone marrow:7.29 adipose:6.75 bone:- skin:6.75
CAGE cerebrum:2.23 cerebellum:- brain stem:2.14 corpus callosum/glia:2.37 pineal gland:1.90 peripheral nerve:- spine:2.14 retina:- eye:- artery/aorta:2.70 vein:2.46 lymphnode:2.29 peripheral blood:- spleen:2.09 thymus:2.48 bone marrow:- adipose:1.71 bone:- skin:-
RNA-seq cerebrum:1.23 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.51 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.82 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:7.30 prostate:- ovary:- testis:34.60 heart:- muscle:- esophagus:- stomach:42.50 intestine:- colon:84.80     liver/hepato:42.20        lung:34.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:46.50 salivary:-
GeneChip uterus:6.54 placenta:6.35 prostate:6.40 ovary:6.53 testis:6.81 heart:6.43 muscle:6.53 esophagus:6.61 stomach:6.72 intestine:6.78 colon:7.08 liver/hepato:6.55 lung:6.68 bladder:- kidney:6.66 pituitary:6.85 thyroid/parathyroid:6.74 adrenal gland:6.59 pancreas:6.72 breast:6.87 salivary:6.73
CAGE uterus:2.16 placenta:1.87 prostate:2.24 ovary:2.02 testis:2.17 heart:2.27 muscle:2.37 esophagus:2.08 stomach:- intestine:2.38 colon:2.82     liver/hepato:1.47    lung:2.46 bladder:2.25 kidney:2.01 pituitary:1.87 thyroid/parathyroid:2.29 adrenal gland:- pancreas:2.18 breast:2.91 salivary:1.49
RNA-seq uterus:- placenta:- prostate:1.71 ovary:1.97 testis:2.00 heart:1.34 muscle:1.73 esophagus:- stomach:- intestine:- colon:2.03     liver/hepato:0.85        lung:0.83    bladder:- kidney:1.25 pituitary:- thyroid/parathyroid:2.23 adrenal gland:2.30 pancreas:- breast:1.73 salivary:-

Gene Information

IDs

Refseq ID NM_181050
Gene ID 8312
Unigene ID Hs.592082
Probe set ID 212849_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000103126
GTEx ID ENSG00000103126

Orthologous Gene

Mouse[3]  NM_001159598, NM_009733
Rat [0]  

Chromosomal Region

16p13.3  [337,440  -  402,673]

Gene Family (Interpro ID)

IPR000342  Regulator of G protein signalling
IPR016137  Regulator of G protein signalling superfamily

Link to Pubmed  (Pubmed ID)

9054936
9230313
9335612
9482734
9601641
9734785
9920888
10228155
10330403
10428961
10488109
10581160
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11719457
11809808
11884395
11955436
11997515
12000790
12036951
12072559
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12192039
12209999
12223491
12417018
12421363
12477932
12511557
12554650
12555076
12556519
12584189
12717450
12771989
12805222
12820959
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12897152
14534723
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14630927
14970870
15063782
15064706
15262978
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15355978
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15520370
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15981102
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16293619
16601693
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16773576
16868183
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17018282
17143297
17210684
17318175
17353931
17418091
17510365
17560945
17569865
17588722
17601533
17720811
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18171349
18330950
18514389
18593713
18632848
18708403
18762581
19038973
19107203
19131971
19141611
19202075
19249679
19303846
19331826
19390532
19453261
19513548
19582507
19633924
19731416
19759537
19778269
19913121
20098615
20122174
20128690
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20531388
20628086
20844743
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21057547
21087614
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21648318
21769465
21795712
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21902576
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22234612
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22509369
22524844
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22682247
22933777
23110995
23192643
23277359
23278310
23455922
23525311
23602568
23671587
23826318
23879168
23915259
23959799
24011952
24419084
24451375
24700460

Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0032147  activation of protein kinase activity
GO:0006915  apoptosis
GO:0048320  axial mesoderm formation
GO:0008219  cell death
GO:0043623  cellular protein complex assembly
GO:0071407  cellular response to organic cyclic substance
GO:0031122  cytoplasmic microtubule organization
GO:0007368  determination of left/right symmetry
GO:0009950  dorsal/ventral axis specification
GO:0048048  embryonic eye morphogenesis
GO:0060272  embryonic skeletal joint morphogenesis
GO:0021797  forebrain anterior/posterior pattern formation
GO:0001701  in utero embryonic development
GO:0055001  muscle cell development
GO:0045599  negative regulation of fat cell differentiation
GO:0051248  negative regulation of protein metabolic process
GO:0034244  negative regulation of RNA elongation from RNA polymerase II promoter
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0006913  nucleocytoplasmic transport
GO:0030910  olfactory placode formation
GO:0001743  optic placode formation
GO:0043547  positive regulation of GTPase activity
GO:0046330  positive regulation of JNK cascade
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0010800  positive regulation of peptidyl-threonine phosphorylation
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045732  positive regulation of protein catabolic process
GO:0031398  positive regulation of protein ubiquitination
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0051443  positive regulation of ubiquitin-protein ligase activity
GO:0030163  protein catabolic process
GO:0051260  protein homooligomerization
GO:0000209  protein polyubiquitination
GO:0007605  sensory perception of sound
GO:0021881  Wnt receptor signaling pathway involved in forebrain neuron fate commitment
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0060823  Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation

Cellular Component

GO:0030877  beta-catenin destruction complex
GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0005881  cytoplasmic microtubule
GO:0031410  cytoplasmic vesicle
GO:0005829  cytosol
GO:0016328  lateral plasma membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0014069  postsynaptic density

Molecular Function

GO:0070016  armadillo repeat domain binding
GO:0008013  beta-catenin binding
GO:0019899  enzyme binding
GO:0005096  GTPase activator activity
GO:0070411  I-SMAD binding
GO:0042802  identical protein binding
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0032947  protein complex scaffold
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0043621  protein self-association
GO:0070412  R-SMAD binding
GO:0004871  signal transducer activity
GO:0046332  SMAD binding
GO:0031625  ubiquitin protein ligase binding