actin filament associated protein 1-like 2

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Synonym

XB130, KIAA1914, FLJ14564, Protein KIAA1914, Em:AC005383.4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:46.20 cerebellum:75.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:237.30 eye:29.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:132.30 thymus:25.80 bone marrow:- adipose:- bone:- skin:72
GeneChip nodata
CAGE cerebrum:2.97 cerebellum:- brain stem:3.05 corpus callosum/glia:2.86 pineal gland:2.57 peripheral nerve:- spine:2.91 retina:- eye:- artery/aorta:2.94 vein:3.14 lymphnode:2.19 peripheral blood:- spleen:4.70 thymus:2.87 bone marrow:- adipose:2.20 bone:- skin:-
RNA-seq cerebrum:1.77 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.31 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:61.90 prostate:101.40 ovary:37.30 testis:- heart:12.80 muscle:20.10 esophagus:- stomach:21.20 intestine:32.40 colon:59.40     liver/hepato:-        lung:29.30    bladder:125.60 kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:18.60 salivary:-
GeneChip nodata
CAGE uterus:3.98 placenta:2.70 prostate:2.94 ovary:3.25 testis:1.97 heart:2.35 muscle:1.78 esophagus:2.77 stomach:- intestine:2.20 colon:2.47     liver/hepato:1.01    lung:2.04 bladder:2.48 kidney:3.13 pituitary:1.15 thyroid/parathyroid:4.83 adrenal gland:- pancreas:3.23 breast:3.16 salivary:2.22
RNA-seq uterus:- placenta:- prostate:2.88 ovary:3.15 testis:2.58 heart:0.51 muscle:0.00 esophagus:- stomach:- intestine:- colon:2.37     liver/hepato:0.00        lung:1.39    bladder:- kidney:2.67 pituitary:- thyroid/parathyroid:5.51 adrenal gland:2.31 pancreas:- breast:2.20 salivary:-

Gene Information

IDs

Refseq ID NM_001001936
Gene ID 84632
Unigene ID Hs.501106
Probe set ID -
Ensembl ID ENSG00000169129
GTEx ID ENSG00000169129

Orthologous Gene

Mouse[1]  NM_001177796, NM_001177797, NM_146102
Rat[1]  NM_001177796, NM_001177797, NM_146102

Chromosomal Region

10q25.3  [116,054,583  -  116,164,515]

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology

Link to Pubmed  (Pubmed ID)

11572484
12477932
14702039
15164054
15489334
15951569
16385451
16713569
17412687
18029348
20125193
20201926
21044950
21224076
21832049
22190283
22805860
22927913
22928011
23527086

Gene Ontology  (GO ID)

Biological Process

GO:0006954  inflammatory response
GO:0045742  positive regulation of epidermal growth factor receptor signaling pathway
GO:0032757  positive regulation of interleukin-8 production
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0032675  regulation of interleukin-6 production
GO:0007346  regulation of mitotic cell cycle

Cellular Component

GO:0016235  aggresome
GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005543  phospholipid binding
GO:0030296  protein tyrosine kinase activator activity
GO:0042169  SH2 domain binding
GO:0017124  SH3 domain binding