neuropeptide FF-amide peptide precursor

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Synonym

NPFF, FMRFAL, neuropeptide FF-amide peptide precursor, FMRFamide-related peptides precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.16 cerebellum:6.23 brain stem:6.18 corpus callosum/glia:6.15 pineal gland:- peripheral nerve:5.92 spine:6.13 retina:- eye:- artery/aorta:6.47 vein:6.26 lymphnode:6.22 peripheral blood:- spleen:6.12 thymus:5.67 bone marrow:6.14 adipose:6.13 bone:- skin:6.21
CAGE cerebrum:0.03 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0.67 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0.18 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.87 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.55 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.96 placenta:5.84 prostate:5.79 ovary:5.86 testis:5.91 heart:6.28 muscle:5.97 esophagus:5.97 stomach:6.15 intestine:6.20 colon:6.25 liver/hepato:6.29 lung:6.37 bladder:- kidney:6.20 pituitary:6.20 thyroid/parathyroid:5.99 adrenal gland:6.37 pancreas:6.64 breast:5.96 salivary:6.28
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:1.04 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:1.92 ovary:1.38 testis:3.19 heart:0.61 muscle:0 esophagus:- stomach:- intestine:- colon:0.74     liver/hepato:0.74        lung:1.61    bladder:- kidney:1.73 pituitary:- thyroid/parathyroid:0.27 adrenal gland:1.54 pancreas:- breast:1.85 salivary:-

Gene Information

IDs

Refseq ID NM_003717
Gene ID 8620
Unigene ID -
Probe set ID 206402_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000139574
GTEx ID ENSG00000139574

Orthologous Gene

Mouse[1]  NM_018787
Rat[1]  NM_018787

Chromosomal Region

12q13.13  [53,900,472  -  53,902,004]

Gene Family (Interpro ID)

IPR008065  FMRFamide-related peptide 2
IPR017382  FMRFamide-related peptide 2, subgroup

Link to Pubmed  (Pubmed ID)

7784266
8804117
9224703
9786165
10851242
11024015
11325787
11587714
12149260
12477932
12609745
16336216
16754659
17224450
17854890
18577758
21120930
23333304

Gene Ontology  (GO ID)

Biological Process

GO:0002438  acute inflammatory response to antigenic stimulus
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0060135  maternal process involved in female pregnancy
GO:0032099  negative regulation of appetite
GO:0010459  negative regulation of heart rate
GO:0046676  negative regulation of insulin secretion
GO:0007218  neuropeptide signaling pathway
GO:0045777  positive regulation of blood pressure
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0051930  regulation of sensory perception of pain
GO:0042493  response to drug
GO:0043278  response to morphine
GO:0070253  somatostatin secretion
GO:0021510  spinal cord development
GO:0007268  synaptic transmission
GO:0030103  vasopressin secretion

Cellular Component

GO:0030425  dendrite
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0043679  nerve terminal
GO:0043204  perikaryon
GO:0031982  vesicle

Molecular Function

GO:0001664  G-protein-coupled receptor binding
GO:0005184  neuropeptide hormone activity
GO:0005102  receptor binding