patched homolog 2 (Drosophila)

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Synonym

PTC2, Protein patched homolog 2, patched (Drosophila) homolog 2, PTCH2, patched homolog 2 (Drosophila), UNQ560/PRO1121

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:36.40 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.99 cerebellum:5.93 brain stem:5.94 corpus callosum/glia:5.77 pineal gland:- peripheral nerve:6.39 spine:5.91 retina:- eye:- artery/aorta:5.78 vein:5.91 lymphnode:5.84 peripheral blood:- spleen:5.46 thymus:5.40 bone marrow:5.76 adipose:5.94 bone:- skin:5.87
CAGE cerebrum:2.22 cerebellum:- brain stem:1.66 corpus callosum/glia:1.59 pineal gland:2.75 peripheral nerve:- spine:2.76 retina:- eye:- artery/aorta:1.79 vein:1.95 lymphnode:1.33 peripheral blood:- spleen:0.56 thymus:0.50 bone marrow:- adipose:0.78 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.22 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:13 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.79 placenta:5.49 prostate:5.41 ovary:5.95 testis:6.28 heart:5.70 muscle:5.89 esophagus:5.75 stomach:5.95 intestine:5.80 colon:6 liver/hepato:5.82 lung:5.71 bladder:- kidney:5.73 pituitary:6.24 thyroid/parathyroid:5.87 adrenal gland:5.87 pancreas:6.20 breast:5.67 salivary:6.62
CAGE uterus:2.44 placenta:0.16 prostate:1.69 ovary:3.72 testis:3.81 heart:1.00 muscle:0.52 esophagus:1.08 stomach:- intestine:0.33 colon:1.33     liver/hepato:0.14    lung:0.89 bladder:1.95 kidney:0.58 pituitary:2.44 thyroid/parathyroid:1.25 adrenal gland:- pancreas:0 breast:0.90 salivary:3.34
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.24 testis:0.74 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.04     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.04 pituitary:- thyroid/parathyroid:0.02 adrenal gland:0.19 pancreas:- breast:0.14 salivary:-

Gene Information

IDs

Refseq ID NM_001166292
Gene ID 8643
Unigene ID Hs.601603
Probe set ID 221292_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000117425
GTEx ID ENSG00000117425

Orthologous Gene

Mouse[1]  NM_008958
Rat[1]  NM_008958

Chromosomal Region

1p34.1  [45,285,516  -  45,308,735]

Gene Family (Interpro ID)

IPR003392  Patched
IPR004766  Transmembrane receptor, patched

Link to Pubmed  (Pubmed ID)

9811851
9931336
10029063
11001584
12477932
12975309
14613484
16710414
17620599
18285427
19208383
19221557
19237606
20301330
20634891
23479190

Gene Ontology  (GO ID)

Biological Process

GO:0008544  epidermis development
GO:0042633  hair cycle
GO:0045879  negative regulation of smoothened signaling pathway

Cellular Component

GO:0016021  integral to membrane

Molecular Function

GO:0008158  hedgehog receptor activity
GO:0005119  smoothened binding