ribosomal protein S6 kinase, 90kDa, polypeptide 4

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Synonym

Ribosomal protein S6 kinase alpha-4, RSK-B, MSK2, 90 kDa ribosomal protein S6 kinase 4, RPS6KA4, ribosomal protein S6 kinase, 90kDa, polypeptide 4, Ribosomal protein kinase B, RSKB

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:27.30 cerebellum:75.60 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:11.80 artery/aorta:30 vein:66.60 lymphnode:10.10 peripheral blood:182.20 spleen:37.80 thymus:25.80 bone marrow:- adipose:40.30 bone:76.80 skin:9.60
GeneChip cerebrum:7.09 cerebellum:7.21 brain stem:7.14 corpus callosum/glia:6.86 pineal gland:- peripheral nerve:6.72 spine:6.93 retina:- eye:- artery/aorta:6.79 vein:6.81 lymphnode:7.08 peripheral blood:- spleen:6.94 thymus:6.40 bone marrow:6.92 adipose:6.90 bone:- skin:6.93
CAGE cerebrum:2.98 cerebellum:- brain stem:3.02 corpus callosum/glia:3.05 pineal gland:2.14 peripheral nerve:- spine:2.74 retina:- eye:- artery/aorta:2.69 vein:2.84 lymphnode:3.09 peripheral blood:- spleen:2.81 thymus:2.39 bone marrow:- adipose:2.55 bone:- skin:-
RNA-seq cerebrum:1.25 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.67 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:36.40 prostate:33.80 ovary:37.30 testis:- heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:50.90     liver/hepato:10.60        lung:4.90    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:9.30 salivary:-
GeneChip uterus:6.58 placenta:6.51 prostate:6.40 ovary:6.52 testis:6.36 heart:6.84 muscle:6.74 esophagus:6.96 stomach:6.90 intestine:6.79 colon:7.02 liver/hepato:7 lung:6.76 bladder:- kidney:6.91 pituitary:6.83 thyroid/parathyroid:6.54 adrenal gland:6.97 pancreas:6.85 breast:6.80 salivary:6.82
CAGE uterus:2.38 placenta:3.00 prostate:2.41 ovary:2.37 testis:1.64 heart:2.51 muscle:2.54 esophagus:2.59 stomach:- intestine:2.66 colon:2.59     liver/hepato:2.57    lung:2.45 bladder:1.88 kidney:2.48 pituitary:1.39 thyroid/parathyroid:2.06 adrenal gland:- pancreas:2.26 breast:2.47 salivary:2.46
RNA-seq uterus:- placenta:- prostate:2.14 ovary:3.16 testis:2.08 heart:1.60 muscle:1.91 esophagus:- stomach:- intestine:- colon:2.26     liver/hepato:1.34        lung:2.06    bladder:- kidney:2.44 pituitary:- thyroid/parathyroid:2.44 adrenal gland:3.31 pancreas:- breast:2.52 salivary:-

Gene Information

IDs

Refseq ID NM_003942
Gene ID 8986
Unigene ID Hs.105584
Probe set ID 204632_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000162302
GTEx ID ENSG00000162302

Orthologous Gene

Mouse[1]  NM_019924
Rat[1]  NM_001108517

Chromosomal Region

11q13.1  [64,126,620  -  64,139,687]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8125298
8688081
9687510
9792677
9829964
9921902
10806207
11035004
11175347
11438671
11909979
12477932
12773393
17192257
17495961
18029348
18508628
19531213
19933278
19953087
20805296
20864036
21252943
21385567
21399635
21890473
21906983
22019778
22939629
23128233
23602568
23675462
24163370
24457600
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0043987  histone H3-S10 phosphorylation
GO:0043988  histone H3-S28 phosphorylation
GO:0016572  histone phosphorylation
GO:0006954  inflammatory response
GO:0070498  interleukin-1-mediated signaling pathway
GO:0001818  negative regulation of cytokine production
GO:0032793  positive regulation of CREB transcription factor activity
GO:0035066  positive regulation of histone acetylation
GO:0033129  positive regulation of histone phosphorylation
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0006355  regulation of transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0000287  magnesium ion binding
GO:0048273  mitogen-activated protein kinase p38 binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0004711  ribosomal protein S6 kinase activity