T-box 18

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Synonym

T-box 18, T-box transcription factor TBX18, TBX18, T-box protein 18

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:7.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:429.40 spine:- retina:- eye:5.90 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:80.70 bone:25.60 skin:-
GeneChip nodata
CAGE cerebrum:1.43 cerebellum:- brain stem:2.02 corpus callosum/glia:1.92 pineal gland:1.77 peripheral nerve:- spine:1.94 retina:- eye:- artery/aorta:3.85 vein:1.76 lymphnode:1.15 peripheral blood:- spleen:0 thymus:0.33 bone marrow:- adipose:2.42 bone:- skin:-
RNA-seq cerebrum:0.42 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.63 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.01 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:3.60 prostate:- ovary:- testis:34.60 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE uterus:1.82 placenta:0.95 prostate:2.04 ovary:1.82 testis:1.11 heart:2.44 muscle:1.20 esophagus:1.81 stomach:- intestine:0.38 colon:0.75     liver/hepato:0.14    lung:0.64 bladder:2.35 kidney:0.39 pituitary:1.61 thyroid/parathyroid:1.07 adrenal gland:- pancreas:0 breast:3.09 salivary:1.75
RNA-seq uterus:- placenta:- prostate:2.40 ovary:1.53 testis:1.35 heart:0.84 muscle:0.44 esophagus:- stomach:- intestine:- colon:0.96     liver/hepato:0.05        lung:0.55    bladder:- kidney:0.49 pituitary:- thyroid/parathyroid:0.71 adrenal gland:1.78 pancreas:- breast:2.10 salivary:-

Gene Information

IDs

Refseq ID NM_001080508
Gene ID 9096
Unigene ID Hs.251830
Probe set ID -
Ensembl ID ENSG00000112837
GTEx ID ENSG00000112837

Orthologous Gene

Mouse[1]  NM_023814
Rat[1]  NM_001108173

Chromosomal Region

6q14.3  [85,397,091  -  85,474,237]

Gene Family (Interpro ID)

IPR001699  Transcription factor, T-box

Link to Pubmed  (Pubmed ID)

9888994
12477932
14574404
16688725
17584735
19213963
21205823
23242162

Gene Ontology  (GO ID)

Biological Process

GO:0009948  anterior/posterior axis specification
GO:0090103  cochlea morphogenesis
GO:0016331  morphogenesis of embryonic epithelium
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0060829  negative regulation of Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0022409  positive regulation of cell-cell adhesion
GO:0050679  positive regulation of epithelial cell proliferation
GO:0007605  sensory perception of sound
GO:0003163  sinoatrial node development
GO:0051145  smooth muscle cell differentiation
GO:0001756  somitogenesis

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0003700  transcription factor activity