ribosomal protein S6 kinase, 90kDa, polypeptide 5

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Synonym

Ribosomal protein S6 kinase alpha-5, RSKL, RSK-like protein kinase, RLPK, MGC1911, MSK1, MSPK1, ribosomal protein S6 kinase, 90kDa, polypeptide 5, RPS6KA5, 90 kDa ribosomal protein S6 kinase 5

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:46.20 cerebellum:37.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:23.50 artery/aorta:30 vein:- lymphnode:80.90 peripheral blood:18.20 spleen:- thymus:38.70 bone marrow:118.10 adipose:- bone:12.80 skin:28.80
GeneChip cerebrum:7.15 cerebellum:7.49 brain stem:6.93 corpus callosum/glia:7.71 pineal gland:- peripheral nerve:6.73 spine:7.57 retina:- eye:- artery/aorta:6.15 vein:5.96 lymphnode:6.47 peripheral blood:- spleen:6.94 thymus:6.39 bone marrow:6.43 adipose:6.24 bone:- skin:6.30
CAGE cerebrum:3.38 cerebellum:- brain stem:3.33 corpus callosum/glia:3.42 pineal gland:2.63 peripheral nerve:- spine:3.49 retina:- eye:- artery/aorta:2.50 vein:2.46 lymphnode:2.63 peripheral blood:- spleen:2.20 thymus:2.44 bone marrow:- adipose:1.86 bone:- skin:-
RNA-seq cerebrum:2.64 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.08 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.93 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:54.60 prostate:22.50 ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:85 intestine:32.40 colon:42.40     liver/hepato:-        lung:24.40    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:37.20 salivary:-
GeneChip uterus:6.67 placenta:8.22 prostate:6.41 ovary:6.51 testis:5.95 heart:6.33 muscle:6.71 esophagus:6.48 stomach:6.82 intestine:6.39 colon:6.44 liver/hepato:5.82 lung:6.28 bladder:- kidney:5.85 pituitary:6.69 thyroid/parathyroid:6.54 adrenal gland:5.66 pancreas:5.59 breast:7.03 salivary:6.47
CAGE uterus:3.09 placenta:3.53 prostate:3.03 ovary:2.27 testis:2.17 heart:2.23 muscle:2.81 esophagus:3.02 stomach:- intestine:3.15 colon:3.18     liver/hepato:1.41    lung:2.51 bladder:3.18 kidney:1.55 pituitary:2.71 thyroid/parathyroid:1.85 adrenal gland:- pancreas:2.48 breast:2.53 salivary:2.78
RNA-seq uterus:- placenta:- prostate:3.17 ovary:1.35 testis:1.41 heart:1.82 muscle:1.96 esophagus:- stomach:- intestine:- colon:1.74     liver/hepato:0.27        lung:1.30    bladder:- kidney:0.65 pituitary:- thyroid/parathyroid:1.79 adrenal gland:1.21 pancreas:- breast:1.13 salivary:-

Gene Information

IDs

Refseq ID NM_004755
Gene ID 9252
Unigene ID Hs.510225
Probe set ID 204635_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100784
GTEx ID ENSG00000100784

Orthologous Gene

Mouse[2]  NM_153587
Rat[1]  NM_001108048

Chromosomal Region

14q32.11  [91,336,799  -  91,526,980]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9343414
9687510
9872331
9873047
10469656
10521505
10635333
10702687
10880354
10978317
11018520
11157753
11297520
11350938
11500364
11777913
11909979
11994045
12421349
12477932
12569367
12576423
12628924
12690113
12763138
12773393
12807421
14551213
14578350
14963018
15010469
15133024
15276183
15302935
15489334
15568999
15797222
16223362
16479592
16532028
16543895
16762916
17117922
17495961
17512525
18424438
18508628
18511904
19015318
19197368
19251839
19633291
19672773
19706715
19933278
20044958
20089855
20129940
20198339
20200978
20354165
20379614
20406806
20408143
20433920
20596523
20805296
20864036
20936779
21282660
21832049
21900206
21988832
22312446
22504420
22626465
22939624
23047923
23604116
23643942
23675462
24250222
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0043990  histone H2A-S1 phosphorylation
GO:0043987  histone H3-S10 phosphorylation
GO:0043988  histone H3-S28 phosphorylation
GO:0016572  histone phosphorylation
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0070498  interleukin-1-mediated signaling pathway
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0001818  negative regulation of cytokine production
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0048011  nerve growth factor receptor signaling pathway
GO:0032793  positive regulation of CREB transcription factor activity
GO:0035066  positive regulation of histone acetylation
GO:0033129  positive regulation of histone phosphorylation
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0006355  regulation of transcription, DNA-dependent
GO:0009605  response to external stimulus
GO:0006950  response to stress
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity