ATP-binding cassette, sub-family G (WHITE), member 1

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Synonym

ABCG1, WHT1, WHITE1, White protein homolog, ATP-binding cassette sub-family G member 1, ABC8, ATP-binding cassette transporter 8, MGC34313

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:51 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:105.80 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:36.40 spleen:37.80 thymus:103.10 bone marrow:98.40 adipose:- bone:25.60 skin:19.20
GeneChip cerebrum:5.21 cerebellum:5.30 brain stem:5.27 corpus callosum/glia:5.46 pineal gland:- peripheral nerve:5.16 spine:4.93 retina:- eye:- artery/aorta:4.66 vein:5.20 lymphnode:5.39 peripheral blood:- spleen:6.08 thymus:5.74 bone marrow:5.24 adipose:5.26 bone:- skin:5.62
CAGE cerebrum:3.41 cerebellum:- brain stem:3.36 corpus callosum/glia:3.82 pineal gland:2.60 peripheral nerve:- spine:3.02 retina:- eye:- artery/aorta:2.86 vein:3.60 lymphnode:3.33 peripheral blood:- spleen:4.26 thymus:3.49 bone marrow:- adipose:3.94 bone:- skin:-
RNA-seq cerebrum:0.56 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.97 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.89 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:18.20 prostate:22.50 ovary:- testis:21.60 heart:12.80 muscle:- esophagus:- stomach:21.20 intestine:- colon:25.40     liver/hepato:21.10        lung:44    bladder:- kidney:31.20 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:62.20 breast:37.20 salivary:-
GeneChip uterus:4.94 placenta:5.70 prostate:4.97 ovary:5.06 testis:4.40 heart:5.28 muscle:5.40 esophagus:4.92 stomach:5.18 intestine:4.99 colon:5.44 liver/hepato:4.89 lung:6.26 bladder:- kidney:5.09 pituitary:5.43 thyroid/parathyroid:4.87 adrenal gland:5.81 pancreas:5.19 breast:5.15 salivary:5.39
CAGE uterus:2.58 placenta:2.93 prostate:2.89 ovary:2.75 testis:1.97 heart:3.16 muscle:3.15 esophagus:2.54 stomach:- intestine:3.75 colon:3.06     liver/hepato:2.33    lung:3.85 bladder:3.47 kidney:2.54 pituitary:3.17 thyroid/parathyroid:2.36 adrenal gland:- pancreas:1.59 breast:3.19 salivary:2.97
RNA-seq uterus:- placenta:- prostate:0.39 ovary:1.22 testis:0.00 heart:0.41 muscle:1.32 esophagus:- stomach:- intestine:- colon:2.79     liver/hepato:0.28        lung:2.64    bladder:- kidney:0.59 pituitary:- thyroid/parathyroid:3.30 adrenal gland:1.25 pancreas:- breast:1.62 salivary:-

Gene Information

IDs

Refseq ID NM_016818
Gene ID 9619
Unigene ID Hs.124649
Probe set ID 211113_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000160179
GTEx ID ENSG00000160179

Orthologous Gene

Mouse[2]  NM_009593
Rat[1]  NM_053502

Chromosomal Region

21q22.3  [43,619,799  -  43,720,714]

Gene Family (Interpro ID)

IPR003439  ABC transporter-like
IPR003593  ATPase, AAA+ type, core

Link to Pubmed  (Pubmed ID)

8619474
8659545
8703120
9034316
9110174
10639163
10799558
10830953
10950923
11072082
11162488
11279031
11350058
11500512
11590207
12032171
12477932
14702039
15240127
15489334
15492319
15584507
15994327
16024918
16054053
16357317
16556852
16702602
16730733
16780588
16857950
16870176
16902247
17020879
17082211
17121837
17141191
17187964
17241464
17293612
17387528
17408620
17761632
17848583
18057374
18490524
18599800
18619413
18640393
18660489
18827283
19168441
19287193
19322201
19343046
19481530
19556716
19839639
19895785
19913121
19948975
20057170
20170916
20395595
20585627
20628086
20675829
20713650
20798376
20931526
21111593
21289254
21295304
21722899
21817095
21821149
21978921
22155456
22353356
22365996
22466164
22503545
22505724
22614118
22753765
22772754
22872754
23139370
23172659
23402987
23564066
23770099
23880356
23897420
23990020
24192121
24320932
24393350
24500716
24576892

Gene Ontology  (GO ID)

Biological Process

GO:0042987  amyloid precursor protein catabolic process
GO:0033344  cholesterol efflux
GO:0042632  cholesterol homeostasis
GO:0008203  cholesterol metabolic process
GO:0009720  detection of hormone stimulus
GO:0034436  glycoprotein transport
GO:0034375  high-density lipoprotein particle remodeling
GO:0032367  intracellular cholesterol transport
GO:0042157  lipoprotein metabolic process
GO:0034374  low-density lipoprotein particle remodeling
GO:0010887  negative regulation of cholesterol storage
GO:0010745  negative regulation of macrophage derived foam cell differentiation
GO:0033700  phospholipid efflux
GO:0055091  phospholipid homeostasis
GO:0045542  positive regulation of cholesterol biosynthetic process
GO:0010875  positive regulation of cholesterol efflux
GO:0010872  regulation of cholesterol esterification
GO:0006355  regulation of transcription, DNA-dependent
GO:0055099  response to high density lipoprotein stimulus
GO:0033993  response to lipid
GO:0010033  response to organic substance
GO:0043691  reverse cholesterol transport
GO:0055085  transmembrane transport

Cellular Component

GO:0005789  endoplasmic reticulum membrane
GO:0005768  endosome
GO:0009897  external side of plasma membrane
GO:0005794  Golgi apparatus
GO:0000139  Golgi membrane
GO:0005887  integral to plasma membrane
GO:0005739  mitochondrion
GO:0005886  plasma membrane
GO:0055037  recycling endosome

Molecular Function

GO:0043531  ADP binding
GO:0005524  ATP binding
GO:0015485  cholesterol binding
GO:0017127  cholesterol transporter activity
GO:0034437  glycoprotein transporter activity
GO:0005543  phospholipid binding
GO:0005548  phospholipid transporter activity
GO:0046983  protein dimerization activity
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0034041  sterol-transporting ATPase activity
GO:0019534  toxin transporter activity