inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Synonym

MGC125294, Inducible I kappa-B kinase, IKK-epsilon, IKBKE, I kappa-B kinase epsilon, IkBKE, IKK-i, IKKE, MGC125295, KIAA0151, IKK-E, MGC125297, IKKI

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:6.36

cerebellum:6.20

brain stem:6.35

corpus callosum/glia:6.19

pineal gland:-

peripheral nerve:6.32

spine:6.28

retina:-

eye:-

artery/aorta:6.64

vein:6.53

lymphnode:7.05

peripheral blood:-

spleen:6.83

thymus:6.67

bone marrow:6.57

adipose:6.64

bone:-

skin:6.61

CAGE

cerebrum:1.52

cerebellum:-

brain stem:1.70

corpus callosum/glia:1.52

pineal gland:0.61

peripheral nerve:-

spine:1.92

retina:-

eye:-

artery/aorta:1.88

vein:2.87

lymphnode:3.00

peripheral blood:-

spleen:3.07

thymus:3.28

bone marrow:-

adipose:1.74

bone:-

skin:-

RNA-seq

cerebrum:0.28

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.74

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.36

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:6.35

placenta:6.58

prostate:6.23

ovary:6.25

testis:6.10

heart:6.49

muscle:6.21

esophagus:6.55

stomach:6.59

intestine:6.42

colon:6.64

liver/hepato:6.41

lung:6.59

bladder:-

kidney:6.29

pituitary:6.38

thyroid/parathyroid:6.72

adrenal gland:6.55

pancreas:6.33

breast:6.59

salivary:6.52

CAGE

uterus:1.69

placenta:1.73

prostate:1.67

ovary:1.35

testis:0.66

heart:1.15

muscle:0.65

esophagus:2.43

stomach:-

intestine:2.07

colon:2.52

liver/hepato:1.01

lung:1.88

bladder:1.38

kidney:1.46

pituitary:1.29

thyroid/parathyroid:1.75

adrenal gland:-

pancreas:1.42

breast:0.90

salivary:2.72

RNA-seq

uterus:-

placenta:-

prostate:0.68

ovary:0.39

testis:0.33

heart:0.00

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.11

lung:0.00

bladder:-

kidney:0.94

pituitary:-

thyroid/parathyroid:1.19

adrenal gland:2.15

pancreas:-

breast:0.33

salivary:-

IDs

Refseq ID	NM_014002
Gene ID	9641
Unigene ID	-
Probe set ID	204549_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000143466
GTEx ID	ENSG00000143466

Orthologous Gene

Mouse[1]	NM_019777
Rat[1]	NM_001108854

Chromosomal Region

1q32.1 [206,643,791 - 206,670,223]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis
GO:0006955	immune response
GO:0045087	innate immune response
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0032480	negative regulation of type I interferon production
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006468	protein amino acid phosphorylation
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0002224	toll-like receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0005730	nucleolus
GO:0005634	nucleus
GO:0016605	PML body

Molecular Function

GO:0005524	ATP binding
GO:0008384	IkappaB kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0005515	protein binding
GO:0004672	protein kinase activity

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function