CD74 molecule, major histocompatibility complex, class II invariant chain

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Synonym

Ii, HLA-DR antigens-associated invariant chain, DHLAG, Ia-GAMMA, HLADG, protein 41, Ia antigen-associated invariant chain, CD74, CD74 antigen

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:46.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:445 peripheral nerve:184 spine:- retina:- eye:229.20 artery/aorta:629.50 vein:- lymphnode:262.90 peripheral blood:236.80 spleen:378.10 thymus:51.50 bone marrow:196.80 adipose:322.70 bone:1074.80 skin:172.80
GeneChip cerebrum:9.17 cerebellum:7.66 brain stem:9.97 corpus callosum/glia:10.56 pineal gland:- peripheral nerve:11.41 spine:11.07 retina:- eye:- artery/aorta:10.78 vein:10.50 lymphnode:12.25 peripheral blood:- spleen:12.30 thymus:11.26 bone marrow:10.78 adipose:11.48 bone:- skin:10.45
CAGE cerebrum:6.28 cerebellum:- brain stem:7.05 corpus callosum/glia:7.44 pineal gland:6.31 peripheral nerve:- spine:7.49 retina:- eye:- artery/aorta:7.65 vein:8.77 lymphnode:8.73 peripheral blood:- spleen:8.88 thymus:8.16 bone marrow:- adipose:7.68 bone:- skin:-
RNA-seq cerebrum:2.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.11 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:182.30 placenta:43.70 prostate:112.60 ovary:223.60 testis:8.70 heart:140.50 muscle:180.80 esophagus:- stomach:106.20 intestine:64.80 colon:271.30     liver/hepato:42.20        lung:444.80    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:327.50 adrenal gland:152.40 pancreas:1120.30 breast:408.90 salivary:1642
GeneChip uterus:10.27 placenta:9.02 prostate:9.90 ovary:10.55 testis:8.32 heart:10.46 muscle:8.63 esophagus:10.24 stomach:10.95 intestine:10.64 colon:10.72 liver/hepato:10.06 lung:12.48 bladder:- kidney:10.78 pituitary:9.94 thyroid/parathyroid:10.64 adrenal gland:10.68 pancreas:9.57 breast:11.01 salivary:10.73
CAGE uterus:7.23 placenta:6.31 prostate:7.41 ovary:7.04 testis:6.11 heart:7.01 muscle:6.16 esophagus:6.77 stomach:- intestine:8.07 colon:7.05     liver/hepato:6.97    lung:8.63 bladder:7.03 kidney:8.13 pituitary:6.24 thyroid/parathyroid:6.85 adrenal gland:- pancreas:6.49 breast:6.73 salivary:7.60
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.06 testis:2.70 heart:1.28 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.18     liver/hepato:1.23        lung:3.25    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:2.81 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001025158
Gene ID 972
Unigene ID Hs.436568
Probe set ID 209619_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000019582
GTEx ID ENSG00000019582

Orthologous Gene

Mouse[2]  NM_001042605, NM_010545
Rat [0]  

Chromosomal Region

5q32  [149,781,200  -  149,792,492]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1448172
2121367
2391366
2507633
3001652
3036998
3132422
3459184
3866610
6324166
6576808
6586420
6955026
6982931
7477400
7519244
8316295
8343954
8397411
8574855
9752000
9843486
10022822
10748235
10981873
11593029
11754812
11897800
11927549
12058053
12477932
12782713
12970439
15194762
15475450
15489334
15688398
15845476
15972644
16107560
16242130
16365153
16428763
16439540
16454711
16542748
16618111
16678175
17045821
17142775
17192395
17567581
17959659
18178838
18438604
18524831
18596106
18684948
18719072
18828016
18842989
18941249
19131591
19327048
19423618
19592662
19665027
19845895
19849849
19913121
19946888
20012522
20198449
20357260
20443131
20463068
20628086
20646540
20820776
20864512
21059907
21068258
21228923
21417823
21423200
21543057
21748758
21792010
21832049
21890473
21906983
21922073
21945129
21988832
22039051
22042694
22069105
22178447
22216005
22611320
22659450
22689013
22761382
22889831
22905972
22935920
22942358
22952837
23000905
23289738
23572149
23730214
24035804
24205828
24594996
24663824
24683185
24731748

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0019883  antigen processing and presentation of endogenous antigen
GO:0019886  antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0008283  cell proliferation
GO:0051085  chaperone mediated protein folding requiring cofactor
GO:0006952  defense response
GO:0016064  immunoglobulin mediated immune response
GO:0006886  intracellular protein transport
GO:0043066  negative regulation of apoptosis
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0002906  negative regulation of mature B cell apoptosis
GO:0002792  negative regulation of peptide secretion
GO:0045581  negative regulation of T cell differentiation
GO:0045060  negative thymic T cell selection
GO:0030890  positive regulation of B cell proliferation
GO:0001961  positive regulation of cytokine-mediated signaling pathway
GO:0002606  positive regulation of dendritic cell antigen processing and presentation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0048146  positive regulation of fibroblast proliferation
GO:0060907  positive regulation of macrophage cytokine production
GO:0090023  positive regulation of neutrophil chemotaxis
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0045582  positive regulation of T cell differentiation
GO:0002830  positive regulation of T-helper 2 type immune response
GO:0045059  positive thymic T cell selection
GO:0001516  prostaglandin biosynthetic process
GO:0006461  protein complex assembly
GO:0043030  regulation of macrophage activation
GO:0007165  signal transduction
GO:0045058  T cell selection

Cellular Component

GO:0009986  cell surface
GO:0030669  clathrin-coated endocytic vesicle membrane
GO:0030666  endocytic vesicle membrane
GO:0012507  ER to Golgi transport vesicle membrane
GO:0009897  external side of plasma membrane
GO:0000139  Golgi membrane
GO:0016021  integral to membrane
GO:0005622  intracellular
GO:0043202  lysosomal lumen
GO:0005765  lysosomal membrane
GO:0042613  MHC class II protein complex
GO:0005771  multivesicular body
GO:0005886  plasma membrane
GO:0032588  trans-Golgi network membrane
GO:0030658  transport vesicle membrane
GO:0005773  vacuole

Molecular Function

GO:0001540  beta-amyloid binding
GO:0019955  cytokine binding
GO:0004896  cytokine receptor activity
GO:0042802  identical protein binding
GO:0042289  MHC class II protein binding
GO:0050998  nitric-oxide synthase binding