CD74 molecule, major histocompatibility complex, class II invariant chain

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Ii, HLA-DR antigens-associated invariant chain, DHLAG, Ia-GAMMA, HLADG, protein 41, Ia antigen-associated invariant chain, CD74, CD74 antigen

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:46.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:445 peripheral nerve:184 spine:- retina:- eye:229.20 artery/aorta:629.50 vein:- lymphnode:262.90 peripheral blood:236.80 spleen:378.10 thymus:51.50 bone marrow:196.80 adipose:322.70 bone:1074.80 skin:172.80
GeneChip cerebrum:9.17 cerebellum:7.66 brain stem:9.97 corpus callosum/glia:10.56 pineal gland:- peripheral nerve:11.41 spine:11.07 retina:- eye:- artery/aorta:10.78 vein:10.50 lymphnode:12.25 peripheral blood:- spleen:12.30 thymus:11.26 bone marrow:10.78 adipose:11.48 bone:- skin:10.45
CAGE cerebrum:6.28 cerebellum:- brain stem:7.05 corpus callosum/glia:7.44 pineal gland:6.31 peripheral nerve:- spine:7.49 retina:- eye:- artery/aorta:7.65 vein:8.77 lymphnode:8.73 peripheral blood:- spleen:8.88 thymus:8.16 bone marrow:- adipose:7.68 bone:- skin:-
RNA-seq cerebrum:2.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.11 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:182.30 placenta:43.70 prostate:112.60 ovary:223.60 testis:8.70 heart:140.50 muscle:180.80 esophagus:- stomach:106.20 intestine:64.80 colon:271.30     liver/hepato:42.20        lung:444.80    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:327.50 adrenal gland:152.40 pancreas:1120.30 breast:408.90 salivary:1642
GeneChip uterus:10.27 placenta:9.02 prostate:9.90 ovary:10.55 testis:8.32 heart:10.46 muscle:8.63 esophagus:10.24 stomach:10.95 intestine:10.64 colon:10.72 liver/hepato:10.06 lung:12.48 bladder:- kidney:10.78 pituitary:9.94 thyroid/parathyroid:10.64 adrenal gland:10.68 pancreas:9.57 breast:11.01 salivary:10.73
CAGE uterus:7.23 placenta:6.31 prostate:7.41 ovary:7.04 testis:6.11 heart:7.01 muscle:6.16 esophagus:6.77 stomach:- intestine:8.07 colon:7.05     liver/hepato:6.97    lung:8.63 bladder:7.03 kidney:8.13 pituitary:6.24 thyroid/parathyroid:6.85 adrenal gland:- pancreas:6.49 breast:6.73 salivary:7.60
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.06 testis:2.70 heart:1.28 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.18     liver/hepato:1.23        lung:3.25    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:2.81 pancreas:- breast:0.00 salivary:-

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0019883  antigen processing and presentation of endogenous antigen
GO:0019886  antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0008283  cell proliferation
GO:0051085  chaperone mediated protein folding requiring cofactor
GO:0006952  defense response
GO:0016064  immunoglobulin mediated immune response
GO:0006886  intracellular protein transport
GO:0043066  negative regulation of apoptosis
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0002906  negative regulation of mature B cell apoptosis
GO:0002792  negative regulation of peptide secretion
GO:0045581  negative regulation of T cell differentiation
GO:0045060  negative thymic T cell selection
GO:0030890  positive regulation of B cell proliferation
GO:0001961  positive regulation of cytokine-mediated signaling pathway
GO:0002606  positive regulation of dendritic cell antigen processing and presentation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0048146  positive regulation of fibroblast proliferation
GO:0060907  positive regulation of macrophage cytokine production
GO:0090023  positive regulation of neutrophil chemotaxis
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0045582  positive regulation of T cell differentiation
GO:0002830  positive regulation of T-helper 2 type immune response
GO:0045059  positive thymic T cell selection
GO:0001516  prostaglandin biosynthetic process
GO:0006461  protein complex assembly
GO:0043030  regulation of macrophage activation
GO:0007165  signal transduction
GO:0045058  T cell selection

Cellular Component

GO:0009986  cell surface
GO:0030669  clathrin-coated endocytic vesicle membrane
GO:0030666  endocytic vesicle membrane
GO:0012507  ER to Golgi transport vesicle membrane
GO:0009897  external side of plasma membrane
GO:0000139  Golgi membrane
GO:0016021  integral to membrane
GO:0005622  intracellular
GO:0043202  lysosomal lumen
GO:0005765  lysosomal membrane
GO:0042613  MHC class II protein complex
GO:0005771  multivesicular body
GO:0005886  plasma membrane
GO:0032588  trans-Golgi network membrane
GO:0030658  transport vesicle membrane
GO:0005773  vacuole

Molecular Function

GO:0001540  beta-amyloid binding
GO:0019955  cytokine binding
GO:0004896  cytokine receptor activity
GO:0042802  identical protein binding
GO:0042289  MHC class II protein binding
GO:0050998  nitric-oxide synthase binding