myeloid/lymphoid or mixed-lineage leukemia 4

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Synonym

myeloid/lymphoid or mixed-lineage leukemia 4, MLL4, KIAA0304, HRX2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.10 cerebellum:6.40 brain stem:5.88 corpus callosum/glia:6.13 pineal gland:- peripheral nerve:6.13 spine:5.82 retina:- eye:- artery/aorta:6.54 vein:5.82 lymphnode:6.83 peripheral blood:- spleen:6.71 thymus:6.73 bone marrow:6.34 adipose:6.44 bone:- skin:6.57
CAGE cerebrum:2.72 cerebellum:- brain stem:2.92 corpus callosum/glia:3.13 pineal gland:2.74 peripheral nerve:- spine:2.94 retina:- eye:- artery/aorta:2.90 vein:3.01 lymphnode:3.07 peripheral blood:- spleen:2.79 thymus:2.94 bone marrow:- adipose:2.76 bone:- skin:-
RNA-seq cerebrum:1.28 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.76 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.08 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.29 placenta:6.04 prostate:6.31 ovary:6.19 testis:7.44 heart:5.64 muscle:5.83 esophagus:6.54 stomach:6.33 intestine:5.90 colon:6.24 liver/hepato:6.66 lung:6.40 bladder:- kidney:6.32 pituitary:6.70 thyroid/parathyroid:6.54 adrenal gland:6.48 pancreas:6.28 breast:6.70 salivary:6.24
CAGE uterus:2.73 placenta:2.53 prostate:2.77 ovary:2.80 testis:2.99 heart:2.19 muscle:2.25 esophagus:2.80 stomach:- intestine:2.91 colon:3.05     liver/hepato:2.14    lung:2.76 bladder:2.73 kidney:2.54 pituitary:2.88 thyroid/parathyroid:2.28 adrenal gland:- pancreas:2.71 breast:2.59 salivary:2.50
RNA-seq uterus:- placenta:- prostate:2.27 ovary:2.59 testis:3.72 heart:1.12 muscle:2.34 esophagus:- stomach:- intestine:- colon:1.79     liver/hepato:1.10        lung:2.10    bladder:- kidney:1.80 pituitary:- thyroid/parathyroid:2.44 adrenal gland:2.67 pancreas:- breast:1.63 salivary:-

Gene Information

IDs

Refseq ID NM_014727
Gene ID 9757
Unigene ID -
Probe set ID 203419_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105663
GTEx ID ENSG00000105663

Orthologous Gene

Mouse[1]  NM_029274
Rat[1]  NM_029274

Chromosomal Region

19q13.12  [36,208,921  -  36,229,779]

Gene Family (Interpro ID)

IPR003889  FY-rich, C-terminal
IPR018516  FY-rich, C-terminal subgroup
IPR003888  FY-rich, N-terminal
IPR018518  FY-rich, N-terminal subgroup
IPR019787  Zinc finger, PHD-finger
IPR001965  Zinc finger, PHD-type

Link to Pubmed  (Pubmed ID)

9171351
9205841
10409430
10637508
10744724
12477932
15057824
15231748
15302935
15489334
16147992
16199523
16713569
16751776
17021013
17081983
17166833
17474147
17500065
18029348
18320596
18838538
19047629
19060922
19221051
20305087
20433758
20516061
21502505
21890473
21900206
22266653
22665483
22713656
23000965
23129768
23426673

Gene Ontology  (GO ID)

Biological Process

GO:0048096  chromatin-mediated maintenance of transcription
GO:0016458  gene silencing
GO:0051568  histone H3-K4 methylation
GO:0009994  oocyte differentiation
GO:0001541  ovarian follicle development
GO:0030728  ovulation
GO:0051569  regulation of histone H3-K4 methylation
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0035097  histone methyltransferase complex
GO:0005634  nucleus

Molecular Function

GO:0003677  DNA binding
GO:0042800  histone methyltransferase activity (H3-K4 specific)
GO:0005515  protein binding
GO:0003700  transcription factor activity
GO:0008270  zinc ion binding