Rho guanine nucleotide exchange factor (GEF) 11

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Synonym

Rho guanine nucleotide exchange factor 11, Rho guanine nucleotide exchange factor (GEF) 11, ARHGEF11, KIAA0380, GTRAP48, PDZ-RhoGEF, PDZ-RHOGEF

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:37.90 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:92 spine:112.30 retina:118.60 eye:64.60 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:- spleen:- thymus:- bone marrow:59 adipose:- bone:25.60 skin:105.60
GeneChip cerebrum:6.68 cerebellum:6.85 brain stem:6.82 corpus callosum/glia:6.04 pineal gland:- peripheral nerve:6.99 spine:6.21 retina:- eye:- artery/aorta:6.25 vein:6.31 lymphnode:6.20 peripheral blood:- spleen:6.19 thymus:5.45 bone marrow:6.09 adipose:6.42 bone:- skin:6.24
CAGE cerebrum:3.36 cerebellum:- brain stem:3.06 corpus callosum/glia:2.97 pineal gland:4.76 peripheral nerve:- spine:3.04 retina:- eye:- artery/aorta:3.18 vein:2.74 lymphnode:2.76 peripheral blood:- spleen:2.91 thymus:1.49 bone marrow:- adipose:3.03 bone:- skin:-
RNA-seq cerebrum:2.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.30 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.52 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:43.70 prostate:101.40 ovary:223.60 testis:51.90 heart:38.30 muscle:- esophagus:- stomach:21.20 intestine:- colon:118.70     liver/hepato:31.70        lung:34.20    bladder:- kidney:20.80 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:- pancreas:53.30 breast:37.20 salivary:-
GeneChip uterus:6.36 placenta:6.48 prostate:6.24 ovary:6.28 testis:7.16 heart:6.21 muscle:6.18 esophagus:6.48 stomach:6.37 intestine:6.25 colon:6.33 liver/hepato:6.23 lung:6.28 bladder:- kidney:6.32 pituitary:6.67 thyroid/parathyroid:6.61 adrenal gland:6.51 pancreas:6.18 breast:6.43 salivary:6.22
CAGE uterus:3.11 placenta:2.93 prostate:3.11 ovary:3.04 testis:3.12 heart:3.14 muscle:2.81 esophagus:2.84 stomach:- intestine:3.68 colon:3.42     liver/hepato:2.39    lung:3.14 bladder:2.99 kidney:2.96 pituitary:3.03 thyroid/parathyroid:3.06 adrenal gland:- pancreas:2.76 breast:3.06 salivary:2.43
RNA-seq uterus:- placenta:- prostate:2.24 ovary:2.95 testis:3.20 heart:1.54 muscle:1.47 esophagus:- stomach:- intestine:- colon:2.03     liver/hepato:1.12        lung:2.07    bladder:- kidney:2.13 pituitary:- thyroid/parathyroid:1.99 adrenal gland:1.88 pancreas:- breast:2.53 salivary:-

Gene Information

IDs

Refseq ID NM_014784
Gene ID 9826
Unigene ID Hs.516954
Probe set ID 202913_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000132694
GTEx ID ENSG00000132694

Orthologous Gene

Mouse[1]  NM_001003912
Rat[1]  NM_023982

Chromosomal Region

1q23.1  [156,904,632  -  157,015,162]

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology
IPR000342  Regulator of G protein signalling
IPR016137  Regulator of G protein signalling superfamily

Link to Pubmed  (Pubmed ID)

9205841
10026210
10526156
10900204
11242047
11470431
11756498
12123608
12183458
12220504
12372594
12376548
12421765
12477932
12730235
12787561
14625312
14684465
14742719
15143072
15530360
15755723
16192269
16192272
16478718
16691626
16710414
17081983
17287471
17369523
17474147
17620599
18029348
18086913
18231709
19322201
19460155
19618964
19759375
20368287
20379614
20613766
20800603
20936779
21139048
21210224
21454492
21816819
21988832
24106280

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0007411  axon guidance
GO:0006928  cellular component movement
GO:0000910  cytokinesis
GO:0030010  establishment of cell polarity
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0001558  regulation of cell growth
GO:0035023  regulation of Rho protein signal transduction
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0007266  Rho protein signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0006941  striated muscle contraction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005622  intracellular
GO:0016020  membrane

Molecular Function

GO:0001664  G-protein-coupled receptor binding
GO:0005096  GTPase activator activity
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0005089  Rho guanyl-nucleotide exchange factor activity