PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

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Synonym

FLJ39360, USP52, ubiquitin specific peptidase 52, ubiquitin specific protease 52, hPAN2, KIAA0710

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:83 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:29.40 artery/aorta:- vein:- lymphnode:60.70 peripheral blood:91.10 spleen:37.80 thymus:25.80 bone marrow:157.40 adipose:80.70 bone:- skin:57.60
GeneChip cerebrum:6.67 cerebellum:5.99 brain stem:6.81 corpus callosum/glia:6.46 pineal gland:- peripheral nerve:6.91 spine:6.51 retina:- eye:- artery/aorta:6.20 vein:5.68 lymphnode:6.41 peripheral blood:- spleen:6.53 thymus:6.56 bone marrow:5.82 adipose:6.38 bone:- skin:6.19
CAGE cerebrum:2.77 cerebellum:- brain stem:3.15 corpus callosum/glia:3.31 pineal gland:2.96 peripheral nerve:- spine:2.99 retina:- eye:- artery/aorta:1.75 vein:2.54 lymphnode:2.22 peripheral blood:- spleen:2.39 thymus:3.05 bone marrow:- adipose:2.27 bone:- skin:-
RNA-seq cerebrum:0.98 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.53 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.55 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:18.20 prostate:33.80 ovary:37.30 testis:177.40 heart:89.40 muscle:20.10 esophagus:- stomach:106.20 intestine:- colon:76.30     liver/hepato:10.60        lung:58.70    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:115.60 breast:46.50 salivary:-
GeneChip uterus:7.01 placenta:7.42 prostate:7.70 ovary:6.91 testis:6.30 heart:5.97 muscle:5.11 esophagus:6.60 stomach:6.97 intestine:6.72 colon:6.72 liver/hepato:7.15 lung:6.01 bladder:- kidney:6.97 pituitary:8 thyroid/parathyroid:7.37 adrenal gland:7 pancreas:6.59 breast:6.89 salivary:7.79
CAGE uterus:2.81 placenta:2.39 prostate:2.74 ovary:2.53 testis:3.39 heart:2.15 muscle:1.78 esophagus:2.44 stomach:- intestine:2.78 colon:2.35     liver/hepato:2.81    lung:2.26 bladder:2.36 kidney:2.69 pituitary:3.37 thyroid/parathyroid:3.37 adrenal gland:- pancreas:2.60 breast:2.79 salivary:2.99
RNA-seq uterus:- placenta:- prostate:1.00 ovary:0.64 testis:1.41 heart:0.05 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.16     liver/hepato:1.19        lung:0.39    bladder:- kidney:2.00 pituitary:- thyroid/parathyroid:0.95 adrenal gland:1.00 pancreas:- breast:0.84 salivary:-

Gene Information

IDs

Refseq ID NM_001166279
Gene ID 9924
Unigene ID Hs.273397
Probe set ID 209796_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135473
GTEx ID ENSG00000135473

Orthologous Gene

Mouse[1]  NM_133992
Rat[1]  NM_001008862

Chromosomal Region

12q13.3  [56,710,007  -  56,727,837]

Gene Family (Interpro ID)

IPR006055  Exonuclease
IPR013520  Exonuclease, RNase T/DNA polymerase III
IPR012337  Polynucleotidyl transferase, ribonuclease H fold

Link to Pubmed  (Pubmed ID)

9734811
11148209
12477932
12838346
14583602
14702039
14715245
15489334
16284618
16344560
16964243
17785442
18056425
19615732
19913121
20628086
21139048
21890473
23105109
23398456
24144296
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0010467  gene expression
GO:0016071  mRNA metabolic process
GO:0000288  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000184  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289  nuclear-transcribed mRNA poly(A) tail shortening
GO:0016070  RNA metabolic process
GO:0006511  ubiquitin-dependent protein catabolic process

Cellular Component

GO:0000932  cytoplasmic mRNA processing body
GO:0005829  cytosol
GO:0005634  nucleus
GO:0031251  PAN complex

Molecular Function

GO:0000175  3'-5'-exoribonuclease activity
GO:0003676  nucleic acid binding
GO:0004535  poly(A)-specific ribonuclease activity
GO:0005515  protein binding
GO:0004221  ubiquitin thiolesterase activity