ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

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Synonym

centaurin, delta 3, Centd3, AI851258, mKIAA4097, Centaurin-delta 3, E030006K04Rik, Drag1, ARAP3, KIAA4097, Cnt-d3, DRAG1, Arap3, Kiaa4097

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:5.48 cerebellum:5.21 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.62 spine:5.81 retina:4.80 eye:5.08 artery/aorta:- vein:6.42 lymphnode:7.20 peripheral blood:- spleen:7.02 thymus:- bone marrow:8.65 adipose:7.14 bone:8.32 skin:6.19
CAGE cerebrum:1.62 cerebellum:- brain stem:1.94 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.25 retina:- eye:- artery/aorta:3.16 vein:- lymphnode:2.45 peripheral blood:- spleen:2.60 thymus:1.06 bone marrow:- adipose:- bone:3.49 skin:2.39
RNA-seq cerebrum:1.58 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.78 placenta:6.46 prostate:5.98 ovary:7.61 testis:4.89 heart:8.07 muscle:7.67 esophagus:- stomach:6.14 intestine:5.95 colon:- liver/hepato:6.66 lung:10.69 bladder:6.06 kidney:6.71 pituitary:6.50 thyroid/parathyroid:- adrenal gland:7.93 pancreas:5.94 breast:7.09 salivary:6.08
CAGE uterus:2.60 placenta:2.78 prostate:1.02 ovary:2.69 testis:0.45 heart:- muscle:- esophagus:- stomach:1.75 intestine:1.60 colon:2.13     liver/hepato:2.29    lung:4.39 bladder:2.07 kidney:- pituitary:2.18 thyroid/parathyroid:- adrenal gland:2.97 pancreas:2.03 breast:2.59 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.94 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.58        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_139206
Gene ID 106952
Unigene ID -
Probe set ID 1419833_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024451

Orthologous Gene

Human[1]  NM_022481
Rat[1]  NM_022481

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology
IPR008936  Rho GTPase activation protein
IPR000198  RhoGAP
IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type

Link to Pubmed  (Pubmed ID)

8889548
10349636
11042159
11076861
11217851
11804589
12466851
12477932
15489334
15546919
16141072
16141073
16602821
18554416
18765673
19064729
20978237
21267068
21490342
21677750
22535667
23180820
24163130

Gene Ontology  (GO ID)

Biological Process

GO:0030336  negative regulation of cell migration
GO:0035021  negative regulation of Rac protein signal transduction
GO:0035024  negative regulation of Rho protein signal transduction
GO:0032312  regulation of ARF GTPase activity
GO:0008360  regulation of cell shape
GO:0007165  signal transduction

Cellular Component

GO:0042995  cell projection
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005622  intracellular
GO:0030027  lamellipodium
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0001726  ruffle

Molecular Function

GO:0008060  ARF GTPase activator activity
GO:0005096  GTPase activator activity
GO:0046872  metal ion binding
GO:0005547  phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325  phosphatidylinositol-3,4-bisphosphate binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0030675  Rac GTPase activator activity
GO:0005100  Rho GTPase activator activity
GO:0008270  zinc ion binding