thymoma viral proto-oncogene 2

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Synonym

Protein kinase B, beta, PKBbeta, 2410016A19Rik, RAC-PK-beta, Protein kinase Akt-2, MGC14031, AW554154, thymoma viral proto-oncogene 2, PKB beta, RAC-beta serine/threonine-protein kinase, Akt2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:192.80 cerebellum:221 brain stem:95.30 corpus callosum/glia:- pineal gland:- peripheral nerve:114.70 spine:- retina:32.10 eye:106.40 artery/aorta:168.80 vein:- lymphnode:- peripheral blood:57.50 spleen:- thymus:69.20 bone marrow:64.10 adipose:- bone:275.50 skin:118.80
GeneChip cerebrum:8.19 cerebellum:8.67 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.66 spine:8.11 retina:7.72 eye:8.18 artery/aorta:- vein:8.56 lymphnode:8.60 peripheral blood:- spleen:8.80 thymus:- bone marrow:8.56 adipose:9.71 bone:8.57 skin:8.68
CAGE cerebrum:4.19 cerebellum:- brain stem:3.40 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.31 retina:- eye:- artery/aorta:6.07 vein:- lymphnode:4.19 peripheral blood:- spleen:3.40 thymus:4.39 bone marrow:- adipose:- bone:3.83 skin:4.41
RNA-seq cerebrum:21.35 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:218.10 placenta:82.80 prostate:- ovary:68.90 testis:546.80 heart:241.80 muscle:426.10 esophagus:- stomach:65.50 intestine:- colon:88.10     liver/hepato:99.60        lung:90.40    bladder:132.40 kidney:32.20 pituitary:426.30 thyroid/parathyroid:337.40 adrenal gland:- pancreas:93.80 breast:137.10 salivary:108
GeneChip uterus:8.85 placenta:8.43 prostate:8.85 ovary:9.19 testis:8.65 heart:9.41 muscle:9.98 esophagus:- stomach:8.72 intestine:7.91 colon:- liver/hepato:9.07 lung:8.66 bladder:8.48 kidney:8.52 pituitary:8.45 thyroid/parathyroid:- adrenal gland:8.99 pancreas:8.87 breast:9.20 salivary:8.71
CAGE uterus:3.48 placenta:3.74 prostate:3.50 ovary:4.17 testis:4.59 heart:- muscle:- esophagus:- stomach:4.05 intestine:3.40 colon:3.36     liver/hepato:4.14    lung:3.91 bladder:4.02 kidney:- pituitary:3.86 thyroid/parathyroid:- adrenal gland:4.53 pancreas:4.41 breast:3.70 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:36.76 esophagus:- stomach:- intestine:- colon:-     liver/hepato:12.50        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007434
Gene ID 11652
Unigene ID Mm.177194
Probe set ID 1424480_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000004056

Orthologous Gene

Human[2]  NM_001243027, NM_001243028, NM_001626
Rat [0]  

Chromosomal Region

7A3  [28,376,571  -  28,425,845]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR001849  Pleckstrin homology
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

219800
3037531
7566964
8889548
8976376
9620559
10349636
10579998
10922068
11042159
11076861
11086988
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19166849
19197940
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19805051
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19883618
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23968884
24056770
24126057
24126911
24169049
24277697
24438685
24642468

Gene Ontology  (GO ID)

Biological Process

GO:0032859  activation of Ral GTPase activity
GO:0006915  apoptosis
GO:0005975  carbohydrate metabolic process
GO:0008643  carbohydrate transport
GO:0032869  cellular response to insulin stimulus
GO:0006006  glucose metabolic process
GO:0005978  glycogen biosynthetic process
GO:0005977  glycogen metabolic process
GO:0008286  insulin receptor signaling pathway
GO:0065002  intracellular protein transmembrane transport
GO:0007275  multicellular organismal development
GO:0032287  myelin maintenance in the peripheral nervous system
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0010748  negative regulation of plasma membrane long-chain fatty acid transport
GO:0033119  negative regulation of RNA splicing
GO:0016310  phosphorylation
GO:0030335  positive regulation of cell migration
GO:0032000  positive regulation of fatty acid beta-oxidation
GO:0010628  positive regulation of gene expression
GO:0046326  positive regulation of glucose import
GO:0010907  positive regulation of glucose metabolic process
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0050927  positive regulation of positive chemotaxis
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0009967  positive regulation of signal transduction
GO:0010765  positive regulation of sodium ion transport
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0031340  positive regulation of vesicle fusion
GO:0006468  protein amino acid phosphorylation
GO:0043491  protein kinase B signaling cascade
GO:0006417  regulation of translation
GO:0006810  transport

Cellular Component

GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0032593  insulin-responsive compartment
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0032587  ruffle membrane
GO:0031982  vesicle

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0005080  protein kinase C binding
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups