amyloid beta (A4) precursor protein-binding, family B, member 1

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Synonym

Fe65 protein, Apbb1, Fe65, Rir

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1210.40 cerebellum:184.20 brain stem:127.10 corpus callosum/glia:- pineal gland:773.40 peripheral nerve:172 spine:47.30 retina:160.70 eye:144.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:19.80 bone marrow:- adipose:- bone:75.10 skin:142.50
GeneChip cerebrum:11.15 cerebellum:11.21 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:10.80 spine:11.32 retina:9.34 eye:7.87 artery/aorta:- vein:7.41 lymphnode:5.97 peripheral blood:- spleen:6.08 thymus:- bone marrow:5.85 adipose:6.69 bone:6.08 skin:6.24
CAGE cerebrum:4.75 cerebellum:- brain stem:4.92 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.88 retina:- eye:- artery/aorta:2.03 vein:- lymphnode:0.71 peripheral blood:- spleen:0.41 thymus:0.82 bone marrow:- adipose:- bone:1.69 skin:1.46
RNA-seq cerebrum:65.84 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:55.20 prostate:- ovary:34.50 testis:7.40 heart:390.60 muscle:177.50 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:70.30    bladder:- kidney:32.20 pituitary:568.40 thyroid/parathyroid:112.50 adrenal gland:- pancreas:37.50 breast:9.80 salivary:-
GeneChip uterus:7.28 placenta:7.37 prostate:6.44 ovary:6.92 testis:7.79 heart:10.04 muscle:6.70 esophagus:- stomach:6.89 intestine:6.64 colon:- liver/hepato:5.73 lung:9.26 bladder:7.80 kidney:6.80 pituitary:10 thyroid/parathyroid:- adrenal gland:7.41 pancreas:7.86 breast:6.36 salivary:6.11
CAGE uterus:1.98 placenta:2.15 prostate:1.84 ovary:1.92 testis:2.05 heart:- muscle:- esophagus:- stomach:1.07 intestine:1.14 colon:1.03     liver/hepato:0.26    lung:3.41 bladder:2.62 kidney:- pituitary:3.65 thyroid/parathyroid:- adrenal gland:2.22 pancreas:0.84 breast:0.86 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.59 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.39        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_009685
Gene ID 11785
Unigene ID Mm.38469
Probe set ID 1423893_x_at  [Mouse430_2]
Ensembl ID ENSMUSG00000037032

Orthologous Gene

Human[1]  NM_001164, NM_145689
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR006020  Phosphotyrosine interaction domain
IPR011993  Pleckstrin homology-type
IPR001202  WW/Rsp5/WWP

Link to Pubmed  (Pubmed ID)

7867517
8889548
8894693
9371744
9407065
9546346
9585438
10349636
10945997
11042159
11076861
11217851
11517249
11544248
12089154
12435432
12466851
12477932
14681479
14689444
15146195
15529118
15647266
15944124
16141072
16141073
16301330
16407979
16638748
16716194
17121854
17130235
17368826
17383198
17855370
18278038
18401706
18468999
18723004
19282473
19343227
19713352
19796171
20036665
20436672
20637285
21103325
21228158
21267068
21878794
22199353
22429478
22560297

Gene Ontology  (GO ID)

Biological Process

GO:0030048  actin filament-based movement
GO:0006915  apoptosis
GO:0007411  axon guidance
GO:0007050  cell cycle arrest
GO:0016568  chromatin modification
GO:0006302  double-strand break repair
GO:0030198  extracellular matrix organization
GO:0043967  histone H4 acetylation
GO:0030308  negative regulation of cell growth
GO:0045665  negative regulation of neuron differentiation
GO:0050760  negative regulation of thymidylate synthase biosynthetic process
GO:0001764  neuron migration
GO:0043065  positive regulation of apoptosis
GO:0045739  positive regulation of DNA repair
GO:0050714  positive regulation of protein secretion
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0050821  protein stabilization
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus
GO:0006351  transcription, DNA-dependent
GO:0008542  visual learning

Cellular Component

GO:0042995  cell projection
GO:0005737  cytoplasm
GO:0043197  dendritic spine
GO:0030426  growth cone
GO:0030027  lamellipodium
GO:0016020  membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0045211  postsynaptic membrane
GO:0042734  presynaptic membrane
GO:0043234  protein complex
GO:0045202  synapse

Molecular Function

GO:0001540  beta-amyloid binding
GO:0003682  chromatin binding
GO:0035035  histone acetyltransferase binding
GO:0042393  histone binding
GO:0070064  proline-rich region binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0008134  transcription factor binding