axin 1

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Synonym

Fused protein, Axin, Kb, knobbly, Fu, MGC132911, fused, kinky, Axis inhibition protein 1, Axin-1, Axin1, AI316800, axin 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:34.70 cerebellum:18.40 brain stem:127.10 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:38.20 spine:47.30 retina:96.40 eye:76 artery/aorta:- vein:- lymphnode:10.80 peripheral blood:28.80 spleen:13.20 thymus:79 bone marrow:38.50 adipose:212.70 bone:37.60 skin:71.30
GeneChip cerebrum:6.52 cerebellum:6.84 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.64 spine:6.64 retina:6.07 eye:6.14 artery/aorta:- vein:6.77 lymphnode:7.30 peripheral blood:- spleen:7.29 thymus:- bone marrow:7.07 adipose:6.63 bone:6.82 skin:6.68
CAGE cerebrum:2.48 cerebellum:- brain stem:1.93 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.35 retina:- eye:- artery/aorta:2.31 vein:- lymphnode:2.62 peripheral blood:- spleen:2.84 thymus:3.14 bone marrow:- adipose:- bone:3.02 skin:2.98
RNA-seq cerebrum:3.79 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:27.60 prostate:- ovary:68.90 testis:44.30 heart:18.60 muscle:35.50 esophagus:- stomach:- intestine:110.90 colon:88.10     liver/hepato:-        lung:70.30    bladder:- kidney:40.30 pituitary:490.90 thyroid/parathyroid:112.50 adrenal gland:- pancreas:28.10 breast:71.80 salivary:54
GeneChip uterus:7.20 placenta:7 prostate:6.79 ovary:6.69 testis:7.54 heart:6.89 muscle:6.82 esophagus:- stomach:7.08 intestine:7.21 colon:- liver/hepato:6.98 lung:6.79 bladder:6.83 kidney:7.05 pituitary:7.11 thyroid/parathyroid:- adrenal gland:6.54 pancreas:6.78 breast:6.70 salivary:6.33
CAGE uterus:2.84 placenta:2.59 prostate:2.57 ovary:2.89 testis:3.25 heart:- muscle:- esophagus:- stomach:3.00 intestine:2.56 colon:2.88     liver/hepato:2.51    lung:2.52 bladder:2.68 kidney:- pituitary:2.87 thyroid/parathyroid:- adrenal gland:2.73 pancreas:2.75 breast:2.49 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.13 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.89        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001159598
Gene ID 12005
Unigene ID Mm.23684
Probe set ID 1426967_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024182

Orthologous Gene

Human[2]  NM_003502, NM_181050
Rat [0]  

Chromosomal Region

17A3.3  [26,275,631  -  26,332,756]

Gene Family (Interpro ID)

IPR000342  Regulator of G protein signalling
IPR016137  Regulator of G protein signalling superfamily

Link to Pubmed  (Pubmed ID)

924142
1350556
2090373
5031320
5940872
6547105
6816725
7276510
7579885
7829069
7894168
8082835
8405974
8536979
8889548
9230313
9335612
9891778
9920888
10318824
10330403
10575011
10581160
10688669
10922068
10937998
11113207
11132407
11170344
11336703
11557983
11703504
11739413
11812828
11829488
11884395
12223491
12477932
12520002
12569091
12601169
12702649
12717450
12805222
12878610
12897152
13340237
14379171
14610273
14664817
14723853
14734535
14966280
14981260
15042511
15057752
15067197
15226823
15327768
15526030
15579909
15820042
15899843
16055716
16055717
16141072
16378759
16510873
16577797
16601693
16602821
16815997
16868943
17053159
17246824
17247179
17247577
17681137
17720811
17934337
18076571
18077588
18083923
18316368
18583422
18606656
18632848
18951693
19075000
19107203
19141611
19204372
19299626
19331826
19515997
19576224
19581931
19623616
19731416
19759537
19828779
20368287
20409609
20436479
20531388
20650886
20883684
21057547
21242974
21267068
21344612
21520248
21652647
21677750
21940452
22071115
22307604
22473005
22509369
22682247
22899650
22933777
22960659
23293290
23535572
23959799
23972596
24093678
24525297

Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0032147  activation of protein kinase activity
GO:0007628  adult walking behavior
GO:0006915  apoptosis
GO:0048318  axial mesoderm development
GO:0048320  axial mesoderm formation
GO:0008219  cell death
GO:0043623  cellular protein complex assembly
GO:0071407  cellular response to organic cyclic substance
GO:0031122  cytoplasmic microtubule organization
GO:0007368  determination of left/right symmetry
GO:0009950  dorsal/ventral axis specification
GO:0009953  dorsal/ventral pattern formation
GO:0048048  embryonic eye morphogenesis
GO:0060272  embryonic skeletal joint morphogenesis
GO:0034101  erythrocyte homeostasis
GO:0021797  forebrain anterior/posterior pattern formation
GO:0020027  hemoglobin metabolic process
GO:0001701  in utero embryonic development
GO:0007275  multicellular organismal development
GO:0055001  muscle cell development
GO:0045599  negative regulation of fat cell differentiation
GO:0051248  negative regulation of protein metabolic process
GO:0034244  negative regulation of RNA elongation from RNA polymerase II promoter
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0050877  neurological system process
GO:0006913  nucleocytoplasmic transport
GO:0030910  olfactory placode formation
GO:0001743  optic placode formation
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0010800  positive regulation of peptidyl-threonine phosphorylation
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045732  positive regulation of protein catabolic process
GO:0045860  positive regulation of protein kinase activity
GO:0031398  positive regulation of protein ubiquitination
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0051443  positive regulation of ubiquitin-protein ligase activity
GO:0030163  protein catabolic process
GO:0051260  protein homooligomerization
GO:0000209  protein polyubiquitination
GO:0001932  regulation of protein amino acid phosphorylation
GO:0007605  sensory perception of sound
GO:0016055  Wnt receptor signaling pathway
GO:0021881  Wnt receptor signaling pathway involved in forebrain neuron fate commitment
GO:0060070  Wnt receptor signaling pathway through beta-catenin
GO:0060823  Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation

Cellular Component

GO:0030877  beta-catenin destruction complex
GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0005881  cytoplasmic microtubule
GO:0031410  cytoplasmic vesicle
GO:0005622  intracellular
GO:0016328  lateral plasma membrane
GO:0016020  membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0043234  protein complex

Molecular Function

GO:0070016  armadillo repeat domain binding
GO:0008013  beta-catenin binding
GO:0019899  enzyme binding
GO:0005096  GTPase activator activity
GO:0070411  I-SMAD binding
GO:0042802  identical protein binding
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0032947  protein complex scaffold
GO:0019904  protein domain specific binding
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0043621  protein self-association
GO:0070412  R-SMAD binding
GO:0004871  signal transducer activity
GO:0046332  SMAD binding
GO:0031625  ubiquitin protein ligase binding