caspase 8

jump to detail

Synonym

caspase 8, Casp8, MACH, CASP-8, Caspase-8 precursor, FLICE, Caspase-8, Mch5

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:133.80

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:518.50

peripheral blood:100.60

spleen:539.80

thymus:-

bone marrow:282.10

adipose:-

bone:75.10

skin:39.60

GeneChip

cerebrum:5.40

cerebellum:5.42

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:5.09

spine:5.61

retina:5.54

eye:6.20

artery/aorta:-

vein:8.65

lymphnode:10.92

peripheral blood:-

spleen:10.07

thymus:-

bone marrow:9.82

adipose:8.99

bone:9.29

skin:8.30

CAGE

cerebrum:1.49

cerebellum:-

brain stem:1.62

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:1.94

retina:-

eye:-

artery/aorta:3.84

vein:-

lymphnode:5.71

peripheral blood:-

spleen:4.01

thymus:4.11

bone marrow:-

adipose:-

bone:4.21

skin:3.92

RNA-seq

cerebrum:1.15

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:13.80

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:37

colon:17.60

liver/hepato:45.30

lung:10

bladder:-

kidney:80.60

pituitary:-

thyroid/parathyroid:112.50

adrenal gland:-

pancreas:9.40

breast:16.30

salivary:-

GeneChip

uterus:9.54

placenta:7.72

prostate:8.80

ovary:8.71

testis:5.62

heart:6.83

muscle:7.56

esophagus:-

stomach:9.64

intestine:10.70

colon:-

liver/hepato:9.37

lung:8.91

bladder:8.30

kidney:8.57

pituitary:6.83

thyroid/parathyroid:-

adrenal gland:8.66

pancreas:7.54

breast:9

salivary:8.71

CAGE

uterus:4.20

placenta:2.94

prostate:3.50

ovary:3.50

testis:1.97

heart:-

muscle:-

esophagus:-

stomach:4.14

intestine:4.80

colon:4.78

liver/hepato:3.92

lung:4.06

bladder:3.58

kidney:-

pituitary:3.06

thyroid/parathyroid:-

adrenal gland:3.54

pancreas:2.45

breast:3.84

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.21

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:3.93

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_001080126
Gene ID	12370
Unigene ID	Mm.336851
Probe set ID	1424552_at [Mouse430_2]
Ensembl ID	ENSMUSG00000026029

Orthologous Gene

Human[11]	NM_001080124, NM_001080125, NM_001228, NM_033355, NM_033356, NM_033358
Rat[1]	NM_022277, NM_001080125, NM_001228, NM_033355, NM_033356, NM_033358

Chromosomal Region

Gene Family (Interpro ID)

IPR001875	Death effector
IPR011029	DEATH-like
IPR011600	Peptidase C14, caspase catalytic
IPR015917	Peptidase C14, caspase precursor p45, core

Gene Ontology (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0001525	angiogenesis
GO:0006915	apoptosis
GO:0007507	heart development
GO:0008625	induction of apoptosis via death domain receptors
GO:0030225	macrophage differentiation
GO:0008152	metabolic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0001841	neural tube formation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045651	positive regulation of macrophage differentiation
GO:0045862	positive regulation of proteolysis
GO:0051291	protein heterooligomerization
GO:0006508	proteolysis
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0042981	regulation of apoptosis
GO:0070243	regulation of thymocyte apoptosis
GO:0045471	response to ethanol
GO:0034612	response to tumor necrosis factor

Cellular Component

GO:0031265	CD95 death-inducing signaling complex
GO:0005813	centrosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031264	death-inducing signaling complex
GO:0045121	membrane raft
GO:0005739	mitochondrion
GO:0043005	neuron projection
GO:0030690	Noc1p-Noc2p complex
GO:0005634	nucleus
GO:0043234	protein complex

Molecular Function

GO:0004197	cysteine-type endopeptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0042802	identical protein binding
GO:0008233	peptidase activity
GO:0002020	protease binding
GO:0005515	protein binding
GO:0005164	tumor necrosis factor receptor binding

caspase 8

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function