dihydrolipoamide dehydrogenase

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Synonym

dihydrolipoamide dehydrogenase, Dld, Dihydrolipoamide dehydrogenase, AI746344, AI315664, dihydrolipoyl dehydrogenase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:79.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:7.60 artery/aorta:- vein:- lymphnode:10.80 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:212.70 bone:25 skin:23.80
GeneChip cerebrum:8.72 cerebellum:9.08 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.09 spine:8.89 retina:7.74 eye:7.45 artery/aorta:- vein:8.32 lymphnode:8.30 peripheral blood:- spleen:7.74 thymus:- bone marrow:8.48 adipose:10.30 bone:8.63 skin:8.38
CAGE cerebrum:4.74 cerebellum:- brain stem:4.81 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.82 retina:- eye:- artery/aorta:6.39 vein:- lymphnode:4.48 peripheral blood:- spleen:4.10 thymus:4.11 bone marrow:- adipose:- bone:4.42 skin:4.24
RNA-seq cerebrum:10.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:41.40 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:70.50     liver/hepato:-        lung:10    bladder:- kidney:8.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:9.40 breast:13.10 salivary:-
GeneChip uterus:8.28 placenta:8.90 prostate:8.69 ovary:9.05 testis:8.28 heart:11.06 muscle:10.52 esophagus:- stomach:9.56 intestine:9.49 colon:- liver/hepato:9.48 lung:8.17 bladder:8.76 kidney:10.42 pituitary:8.37 thyroid/parathyroid:- adrenal gland:9.58 pancreas:7.47 breast:9.64 salivary:7.38
CAGE uterus:4.11 placenta:4.51 prostate:4.38 ovary:4.60 testis:5.07 heart:- muscle:- esophagus:- stomach:5.11 intestine:5.09 colon:4.95     liver/hepato:5.07    lung:4.21 bladder:4.38 kidney:- pituitary:4.28 thyroid/parathyroid:- adrenal gland:5.05 pancreas:4.62 breast:4.94 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:28.38 esophagus:- stomach:- intestine:- colon:-     liver/hepato:16.58        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007861
Gene ID 13382
Unigene ID Mm.313104
Probe set ID 1423159_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020664

Orthologous Gene

Human[1]  NM_000108
Rat[1]  NM_199385

Chromosomal Region

-

Gene Family (Interpro ID)

IPR006258  Dihydrolipoamide dehydrogenase
IPR013027  FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR000815  Mercuric reductase
IPR000103  Pyridine nucleotide-disulphide oxidoreductase, class-II

Link to Pubmed  (Pubmed ID)

8672127
8889548
9169128
9373037
9405644
10349636
10922068
11042159
11076861
11217851
12466851
12477932
12904583
14651853
14681479
15009635
15356189
15782199
15888450
16141072
16141073
17404228
17500595
17626619
18423880
18614015
19573295
21267068
23475850
24391134

Gene Ontology  (GO ID)

Biological Process

GO:0006103  2-oxoglutarate metabolic process
GO:0006086  acetyl-CoA biosynthetic process from pyruvate
GO:0045454  cell redox homeostasis
GO:0051068  dihydrolipoamide metabolic process
GO:0007369  gastrulation
GO:0009106  lipoate metabolic process
GO:0006120  mitochondrial electron transport, NADH to ubiquinone
GO:0055114  oxidation reduction
GO:0006508  proteolysis
GO:0042391  regulation of membrane potential
GO:0048240  sperm capacitation

Cellular Component

GO:0043159  acrosomal matrix
GO:0005929  cilium
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0045252  oxoglutarate dehydrogenase complex
GO:0045254  pyruvate dehydrogenase complex

Molecular Function

GO:0004148  dihydrolipoyl dehydrogenase activity
GO:0050660  FAD binding
GO:0043544  lipoamide binding
GO:0051287  NAD or NADH binding
GO:0016491  oxidoreductase activity
GO:0016668  oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor