Eph receptor A2

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Synonym

AW545284, Sek-2, Ephrin type-A receptor 2 precursor, Myk2, Eck, Tyrosine-protein kinase receptor ECK, SEK-2, Epha2, Eph receptor A2, Sek2, Epithelial cell kinase, MPK-5

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.20 cerebellum:36.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:10.80 peripheral blood:- spleen:65.80 thymus:9.90 bone marrow:- adipose:- bone:37.60 skin:-
GeneChip cerebrum:5.70 cerebellum:6 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.64 spine:5.82 retina:5.90 eye:7.31 artery/aorta:- vein:6.62 lymphnode:6.28 peripheral blood:- spleen:6.25 thymus:- bone marrow:6.43 adipose:6.11 bone:6.54 skin:7.49
CAGE cerebrum:0.13 cerebellum:- brain stem:0.87 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.17 retina:- eye:- artery/aorta:1.28 vein:- lymphnode:0.23 peripheral blood:- spleen:0.52 thymus:0 bone marrow:- adipose:- bone:1.02 skin:2.66
RNA-seq cerebrum:0.93 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:55.20 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.10        lung:20.10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:18.80 breast:3.30 salivary:-
GeneChip uterus:6.53 placenta:6.45 prostate:6.10 ovary:5.79 testis:6.07 heart:6.36 muscle:6.12 esophagus:- stomach:7.65 intestine:7.43 colon:- liver/hepato:7.26 lung:7.95 bladder:6.80 kidney:6.17 pituitary:6.05 thyroid/parathyroid:- adrenal gland:6.67 pancreas:6.11 breast:6.26 salivary:6.77
CAGE uterus:1.54 placenta:1.64 prostate:0.20 ovary:0.69 testis:0 heart:- muscle:- esophagus:- stomach:2.16 intestine:3.06 colon:3.03     liver/hepato:2.32    lung:2.52 bladder:1.94 kidney:- pituitary:0.29 thyroid/parathyroid:- adrenal gland:1.89 pancreas:1.30 breast:1.28 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.28 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.98        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010139
Gene ID 13836
Unigene ID Mm.258105
Probe set ID 1421151_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000006445

Orthologous Gene

Human[1]  NM_004431
Rat[1]  NM_001108977

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001090  Ephrin receptor, ligand binding
IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR016257  Tyrosine-protein kinase, ephrin receptor
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1281307
1295734
2174105
7511603
7543898
7609620
7675446
7737295
7890684
7893599
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7947319
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12520002
12528186
12684176
12702665
12904583
14610273
14660441
14988728
15054110
15145949
15254900
15517401
15872003
16141072
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16166198
16208538
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16735461
16782872
16849550
16977320
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17304517
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18799693
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19542359
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19769959
20100865
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21267068
21344481
21436445
21465626
21559471
21565611
21677750
21799118
22140528
22167091
22247486
22552283
22635007
23308246
23401654
23906066
24026120
24713656

Gene Ontology  (GO ID)

Biological Process

GO:0032863  activation of Rac GTPase activity
GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0048320  axial mesoderm formation
GO:0001568  blood vessel development
GO:0046849  bone remodeling
GO:0060444  branching involved in mammary gland duct morphogenesis
GO:0007155  cell adhesion
GO:0060326  cell chemotaxis
GO:0030154  cell differentiation
GO:0008630  DNA damage response, signal transduction resulting in induction of apoptosis
GO:0048013  ephrin receptor signaling pathway
GO:0030216  keratinocyte differentiation
GO:0070309  lens fiber cell morphogenesis
GO:0033598  mammary gland epithelial cell proliferation
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0021915  neural tube development
GO:0030182  neuron differentiation
GO:0060035  notochord cell development
GO:0014028  notochord formation
GO:0048570  notochord morphogenesis
GO:0001649  osteoblast differentiation
GO:0030316  osteoclast differentiation
GO:0016310  phosphorylation
GO:0090004  positive regulation of establishment of protein localization in plasma membrane
GO:0006468  protein amino acid phosphorylation
GO:0043491  protein kinase B signaling cascade
GO:0045765  regulation of angiogenesis
GO:0043535  regulation of blood vessel endothelial cell migration
GO:0033628  regulation of cell adhesion mediated by integrin
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0010591  regulation of lamellipodium assembly
GO:0070848  response to growth factor stimulus
GO:0001501  skeletal system development
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0001570  vasculogenesis

Cellular Component

GO:0030054  cell junction
GO:0042995  cell projection
GO:0005925  focal adhesion
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0031256  leading edge membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005003  ephrin receptor activity
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity