X-ray repair complementing defective repair in Chinese hamster cells 6

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Synonym

Ku70, CTC75, Ku p70, Xrcc6, CTC box-binding factor 75 kDa subunit, ATP-dependent DNA helicase II 70 kDa subunit, G22p1, ATP-dependent DNA helicase 2 subunit 1, DNA-repair protein XRCC6, Ku autoantigen protein p70 homolog, CTCBF

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:38.20 cerebellum:36.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:57.30 spine:- retina:64.30 eye:45.60 artery/aorta:84.40 vein:- lymphnode:32.40 peripheral blood:129.40 spleen:39.50 thymus:276.60 bone marrow:12.80 adipose:- bone:50.10 skin:31.70
GeneChip nodata
CAGE cerebrum:2.83 cerebellum:- brain stem:2.73 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.48 retina:- eye:- artery/aorta:4.09 vein:- lymphnode:3.34 peripheral blood:- spleen:3.53 thymus:5.18 bone marrow:- adipose:- bone:3.81 skin:2.82
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:82.80 prostate:61.80 ovary:23 testis:29.60 heart:- muscle:35.50 esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:18.10        lung:70.30    bladder:- kidney:8.10 pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:103.20 breast:81.60 salivary:-
GeneChip nodata
CAGE uterus:3.07 placenta:2.55 prostate:2.81 ovary:3.14 testis:3.31 heart:- muscle:- esophagus:- stomach:3.13 intestine:2.92 colon:2.85     liver/hepato:2.76    lung:2.41 bladder:2.70 kidney:- pituitary:3.05 thyroid/parathyroid:- adrenal gland:3.31 pancreas:2.66 breast:3.04 salivary:-
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_001479829
Gene ID 14375
Unigene ID Mm.288809
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Rat [0]  

Chromosomal Region

15E1  [81,818,265  -  81,870,515]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1641347
1701785
2072923
7565861
8597595
8661113
8954777
9223317
9294146
9390689
9582343
9625768
9702186
9736627
9823897
9990036
10349636
10441505
10576891
10716994
10823907
10922068
11042159
11076861
11217851
11248063
11471062
11516951
11751629
12119352
12145306
12466851
12477932
12520002
12551933
12604618
12846809
12904583
14576192
14610273
14668445
14988733
15342428
15485900
15618518
15678105
15741177
15782199
15870260
15979950
16014376
16141072
16141073
16354685
16413926
16440001
16845382
17272272
17318223
17325036
17671430
17875923
18362350
18506893
18584027
18625717
18666816
18710944
18799693
18849970
19057578
19181665
19221393
19247369
19330025
19664609
19692349
19794960
20059953
20133803
20142431
20150414
20339076
20362541
20362542
20383123
20412781
20570964
20966962
21160137
21267068
21327095
21349273
21398614
21677750
21820429
22037767
22265216
22445484
23345432
23474484
23610439
23857907
24394664

Gene Ontology  (GO ID)

Biological Process

GO:0071475  cellular hyperosmotic salinity response
GO:0071481  cellular response to X-ray
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0006302  double-strand break repair
GO:0006303  double-strand break repair via nonhomologous end joining
GO:0008152  metabolic process
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0050769  positive regulation of neurogenesis
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus
GO:0010212  response to ionizing radiation
GO:0000723  telomere maintenance
GO:0006351  transcription, DNA-dependent
GO:0033151  V(D)J recombination

Cellular Component

GO:0005694  chromosome
GO:0005737  cytoplasm
GO:0043564  Ku70:Ku80 complex
GO:0070419  nonhomologous end joining complex
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0043234  protein complex
GO:0005667  transcription factor complex

Molecular Function

GO:0051575  5'-deoxyribose-5-phosphate lyase activity
GO:0005524  ATP binding
GO:0004003  ATP-dependent DNA helicase activity
GO:0003824  catalytic activity
GO:0003684  damaged DNA binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0003691  double-stranded telomeric DNA binding
GO:0004386  helicase activity
GO:0016787  hydrolase activity
GO:0016829  lyase activity
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0008022  protein C-terminus binding
GO:0042162  telomeric DNA binding