histone deacetylase 6

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Synonym

histone deacetylase 6, HD6, Histone deacetylase mHDA2, mHDA2, Sfc6, Hdac5, Histone deacetylase 6, Hdac6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:31.70
GeneChip cerebrum:8.83 cerebellum:8.67 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.13 spine:8.62 retina:7.64 eye:7.34 artery/aorta:- vein:7.85 lymphnode:7.73 peripheral blood:- spleen:7.30 thymus:- bone marrow:7.52 adipose:8.87 bone:7.11 skin:7.82
CAGE cerebrum:2.19 cerebellum:- brain stem:2.25 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.15 retina:- eye:- artery/aorta:1.75 vein:- lymphnode:1.41 peripheral blood:- spleen:1.00 thymus:1.06 bone marrow:- adipose:- bone:0.63 skin:1.84
RNA-seq cerebrum:2.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:8.66 placenta:9.04 prostate:8.12 ovary:8.70 testis:9.45 heart:7.79 muscle:7.32 esophagus:- stomach:7.67 intestine:7.43 colon:- liver/hepato:8.20 lung:7.23 bladder:7.55 kidney:9.67 pituitary:9 thyroid/parathyroid:- adrenal gland:8.38 pancreas:8.14 breast:7.88 salivary:8.16
CAGE uterus:2.03 placenta:2.81 prostate:1.84 ovary:2.09 testis:3.21 heart:- muscle:- esophagus:- stomach:0 intestine:1.49 colon:1.34     liver/hepato:1.64    lung:0.75 bladder:1.31 kidney:- pituitary:2.01 thyroid/parathyroid:- adrenal gland:1.75 pancreas:1.84 breast:2.14 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.56 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.99        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010413
Gene ID 15185
Unigene ID Mm.298546
Probe set ID 1448928_at  [Mouse430_2]
Ensembl ID ENSMUSG00000031161

Orthologous Gene

Human[2]  NM_006044
Rat[2]  NM_006044

Chromosomal Region

XA1.1  [7,507,246  -  7,525,015]

Gene Family (Interpro ID)

IPR000286  Histone deacetylase superfamily

Link to Pubmed  (Pubmed ID)

9891014
10220385
10349636
10391218
10857745
11042159
11044609
11076861
11217851
11544199
11689694
12372765
12466851
12477932
12486003
12606581
14610273
15102857
15347674
15367668
15537544
15782199
15916966
15976449
16141072
16141073
16272578
16602821
16810319
16873063
16899714
16933150
17389687
17785525
17846173
17938201
18180281
18196966
18635817
18799693
18824292
19033385
19457097
19641021
19737819
19893491
19910924
20059953
20075865
20133936
20233974
20360068
20596014
20696758
20886111
21220424
21267068
21444725
21677750
21677773
21731673
21785432
21847094
22022450
22174839
22193721
22210316
22328923
22367781
22457490
22492994
22504143
22575637
22651689
22715468
22778253
22792322
22932141
22955928
22957056
23126280
23152903
23184605
23258539
23364049
23487739
23580651
24035499
24089523
24113571
24146251
24200693
24726361
24747960

Gene Ontology  (GO ID)

Biological Process

GO:0070842  aggresome assembly
GO:0070301  cellular response to hydrogen peroxide
GO:0071218  cellular response to misfolded protein
GO:0016568  chromatin modification
GO:0016575  histone deacetylation
GO:0070932  histone H3 deacetylation
GO:0070933  histone H4 deacetylation
GO:0070846  Hsp90 deacetylation
GO:0006886  intracellular protein transport
GO:0032418  lysosome localization
GO:0016236  macroautophagy
GO:0006515  misfolded or incompletely synthesized protein catabolic process
GO:0007026  negative regulation of microtubule depolymerization
GO:0043242  negative regulation of protein complex disassembly
GO:0045861  negative regulation of proteolysis
GO:0034983  peptidyl-lysine deacetylation
GO:0070845  polyubiquitinated misfolded protein transport
GO:0090035  positive regulation of cellular chaperone-mediated protein complex assembly
GO:0010634  positive regulation of epithelial cell migration
GO:0010870  positive regulation of receptor biosynthetic process
GO:0009967  positive regulation of signal transduction
GO:0006476  protein amino acid deacetylation
GO:0043241  protein complex disassembly
GO:0000209  protein polyubiquitination
GO:0070201  regulation of establishment of protein localization
GO:0010469  regulation of receptor activity
GO:0006355  regulation of transcription, DNA-dependent
GO:0070848  response to growth factor stimulus
GO:0051788  response to misfolded protein
GO:0010033  response to organic substance
GO:0009636  response to toxin
GO:0006351  transcription, DNA-dependent
GO:0090042  tubulin deacetylation
GO:0006511  ubiquitin-dependent protein catabolic process
GO:0043162  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Cellular Component

GO:0016235  aggresome
GO:0005901  caveola
GO:0031252  cell leading edge
GO:0005737  cytoplasm
GO:0005881  cytoplasmic microtubule
GO:0005829  cytosol
GO:0030286  dynein complex
GO:0000118  histone deacetylase complex
GO:0016234  inclusion body
GO:0005874  microtubule
GO:0005875  microtubule associated complex
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0043234  protein complex

Molecular Function

GO:0003779  actin binding
GO:0043014  alpha-tubulin binding
GO:0008013  beta-catenin binding
GO:0048487  beta-tubulin binding
GO:0070840  dynein complex binding
GO:0004407  histone deacetylase activity
GO:0031078  histone deacetylase activity (H3-K14 specific)
GO:0034739  histone deacetylase activity (H3-K16 specific)
GO:0032129  histone deacetylase activity (H3-K9 specific)
GO:0042826  histone deacetylase binding
GO:0051879  Hsp90 protein binding
GO:0016787  hydrolase activity
GO:0046872  metal ion binding
GO:0008017  microtubule binding
GO:0032041  NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969  NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970  NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0031593  polyubiquitin binding
GO:0005515  protein binding
GO:0048156  tau protein binding
GO:0042903  tubulin deacetylase activity
GO:0043130  ubiquitin binding
GO:0008270  zinc ion binding