isocitrate dehydrogenase 3 (NAD+), gamma

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Synonym

isocitrate dehydrogenase 3 (NAD+), gamma, Idh3g, Isocitric dehydrogenase, NAD(+)-specific ICDH

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:140.70 cerebellum:73.70 brain stem:- corpus callosum/glia:- pineal gland:257.80 peripheral nerve:76.40 spine:- retina:289.30 eye:83.60 artery/aorta:- vein:- lymphnode:75.60 peripheral blood:201.30 spleen:118.50 thymus:9.90 bone marrow:38.50 adipose:- bone:50.10 skin:63.30
GeneChip cerebrum:10.74 cerebellum:11.26 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:10.48 spine:10.82 retina:8.83 eye:9.16 artery/aorta:- vein:9.97 lymphnode:11.03 peripheral blood:- spleen:10.44 thymus:- bone marrow:10.90 adipose:12.04 bone:10.69 skin:9.97
CAGE cerebrum:5.13 cerebellum:- brain stem:5.28 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:5.24 retina:- eye:- artery/aorta:7.09 vein:- lymphnode:4.92 peripheral blood:- spleen:4.54 thymus:4.61 bone marrow:- adipose:- bone:5.24 skin:4.87
RNA-seq cerebrum:36.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:110.50 prostate:277.90 ovary:23 testis:59.10 heart:483.60 muscle:426.10 esophagus:- stomach:- intestine:- colon:141     liver/hepato:217.20        lung:170.70    bladder:- kidney:548 pituitary:77.50 thyroid/parathyroid:674.80 adrenal gland:- pancreas:140.70 breast:212.20 salivary:647.90
GeneChip uterus:10.52 placenta:9.59 prostate:10.82 ovary:10.93 testis:7.80 heart:12.52 muscle:12.33 esophagus:- stomach:10.89 intestine:10.90 colon:- liver/hepato:10.26 lung:10.17 bladder:10.51 kidney:12.19 pituitary:10.50 thyroid/parathyroid:- adrenal gland:11.70 pancreas:9.68 breast:11.65 salivary:10.26
CAGE uterus:4.45 placenta:4.19 prostate:4.68 ovary:4.75 testis:3.48 heart:- muscle:- esophagus:- stomach:5.50 intestine:5.40 colon:5.20     liver/hepato:4.68    lung:4.39 bladder:4.84 kidney:- pituitary:4.73 thyroid/parathyroid:- adrenal gland:5.11 pancreas:4.61 breast:5.22 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:81.81 esophagus:- stomach:- intestine:- colon:-     liver/hepato:13.04        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008323
Gene ID 15929
Unigene ID Mm.14825
Probe set ID 1416789_at  [Mouse430_2]
Ensembl ID ENSMUSG00000002010

Orthologous Gene

Human[3]  NM_004135, NM_174869
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR004434  Isocitrate dehydrogenase NAD-dependent, mitochondrial
IPR001804  Isocitrate/isopropylmalate dehydrogenase

Link to Pubmed  (Pubmed ID)

9286695
9730605
10349636
10922068
11042159
11076861
11217851
12466851
12477932
12904583
14610273
14651853
14681479
15572359
15782199
16141072
16141073
17626619
18614015
18799693
21267068
21677750
22083510

Gene Ontology  (GO ID)

Biological Process

GO:0006103  2-oxoglutarate metabolic process
GO:0006102  isocitrate metabolic process
GO:0006734  NADH metabolic process
GO:0045926  negative regulation of growth
GO:0055114  oxidation reduction
GO:0006099  tricarboxylic acid cycle

Cellular Component

GO:0005739  mitochondrion
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0004449  isocitrate dehydrogenase (NAD+) activity
GO:0000287  magnesium ion binding
GO:0046872  metal ion binding
GO:0051287  NAD or NADH binding
GO:0000166  nucleotide binding
GO:0016491  oxidoreductase activity
GO:0016616  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor