interleukin-1 receptor-associated kinase 1

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Synonym

IRAK, Plpk, Interleukin-1 receptor-associated kinase 1, interleukin-1 receptor-associated kinase 1, mPLK, Il1rak, IRAK-1, Pelle-like protein kinase, Irak1, AA408924

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:81.60 cerebellum:55.30 brain stem:95.30 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:96.40 eye:83.60 artery/aorta:84.40 vein:- lymphnode:21.60 peripheral blood:86.30 spleen:65.80 thymus:128.40 bone marrow:64.10 adipose:425.40 bone:75.10 skin:126.70
GeneChip cerebrum:8.05 cerebellum:7.91 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.40 spine:7.72 retina:8.80 eye:9.06 artery/aorta:- vein:8.74 lymphnode:9.13 peripheral blood:- spleen:9.10 thymus:- bone marrow:8.96 adipose:9.32 bone:9.13 skin:9.07
CAGE cerebrum:2.98 cerebellum:- brain stem:3.07 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.03 retina:- eye:- artery/aorta:4.00 vein:- lymphnode:4.23 peripheral blood:- spleen:3.71 thymus:3.02 bone marrow:- adipose:- bone:3.79 skin:3.65
RNA-seq cerebrum:3.14 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:174.50 placenta:13.80 prostate:30.90 ovary:34.50 testis:29.60 heart:74.40 muscle:71 esophagus:- stomach:32.70 intestine:- colon:70.50     liver/hepato:72.40        lung:210.90    bladder:132.40 kidney:72.50 pituitary:64.60 thyroid/parathyroid:- adrenal gland:1697.80 pancreas:131.40 breast:140.40 salivary:162
GeneChip uterus:9.14 placenta:8.73 prostate:9.93 ovary:9.03 testis:6.90 heart:9.01 muscle:8.89 esophagus:- stomach:8.77 intestine:8.59 colon:- liver/hepato:9 lung:8.92 bladder:8.99 kidney:8.85 pituitary:9.80 thyroid/parathyroid:- adrenal gland:10.25 pancreas:10.77 breast:9.15 salivary:9.88
CAGE uterus:3.92 placenta:3.36 prostate:4.19 ovary:3.90 testis:1.34 heart:- muscle:- esophagus:- stomach:3.87 intestine:3.28 colon:3.30     liver/hepato:3.66    lung:3.75 bladder:3.71 kidney:- pituitary:4.13 thyroid/parathyroid:- adrenal gland:4.04 pancreas:5.65 breast:4.19 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:4.89 esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.33        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

IDs

Refseq ID NM_008363
Gene ID 16179
Unigene ID Mm.38241
Probe set ID 1438120_x_at  [Mouse430_2]
Ensembl ID ENSMUSG00000031392

Orthologous Gene

Human[3]  NM_001025242, NM_001025243, NM_001569
Rat[1]  NM_001127555, NM_001025243, NM_001569

Chromosomal Region

-

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0019221  cytokine-mediated signaling pathway
GO:0045087  innate immune response
GO:0070498  interleukin-1-mediated signaling pathway
GO:0007254  JNK cascade
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0016310  phosphorylation
GO:0043507  positive regulation of JUN kinase activity
GO:0043406  positive regulation of MAP kinase activity
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0051259  protein oligomerization
GO:0001959  regulation of cytokine-mediated signaling pathway
GO:0070555  response to interleukin-1
GO:0032496  response to lipopolysaccharide
GO:0032494  response to peptidoglycan
GO:0007165  signal transduction
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005811  lipid particle
GO:0016020  membrane
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0005149  interleukin-1 receptor binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups