IL2-inducible T-cell kinase

Synonym

T-cell-specific kinase, Tcsk, Kinase EMT, Kinase TLK, Emt, Itk, IL2-inducible T-cell kinase, Tyrosine-protein kinase ITK/TSK, Tlk, IL-2-inducible T-cell kinase

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:57.30

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:21.60

peripheral blood:546.30

spleen:434.50

thymus:592.80

bone marrow:-

adipose:212.70

bone:-

skin:15.80

GeneChip

cerebrum:3.91

cerebellum:3.88

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:4.54

spine:3.82

retina:4

eye:3.90

artery/aorta:-

vein:3.86

lymphnode:9.77

peripheral blood:-

spleen:9.22

thymus:-

bone marrow:5.53

adipose:4.34

bone:5.26

skin:4.15

CAGE

cerebrum:0.10

cerebellum:-

brain stem:0

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:0.32

retina:-

eye:-

artery/aorta:1.89

vein:-

lymphnode:5.51

peripheral blood:-

spleen:3.43

thymus:5.83

bone marrow:-

adipose:-

bone:1.97

skin:1.53

RNA-seq

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:37.20

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:16.10

pituitary:12.90

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:3.30

salivary:-

GeneChip

uterus:5.29

placenta:4.22

prostate:3.93

ovary:4.09

testis:3.77

heart:4.23

muscle:4.42

esophagus:-

stomach:4.07

intestine:4.41

colon:-

liver/hepato:4.43

lung:5.18

bladder:3.93

kidney:4.14

pituitary:3.87

thyroid/parathyroid:-

adrenal gland:3.79

pancreas:4.12

breast:5.86

salivary:3.83

CAGE

uterus:0.97

placenta:1.03

prostate:0.51

ovary:1.31

testis:0.45

heart:-

muscle:-

esophagus:-

stomach:1.07

intestine:1.29

colon:2.46

liver/hepato:0.78

lung:3.18

bladder:0.57

kidney:-

pituitary:0.52

thyroid/parathyroid:-

adrenal gland:2.23

pancreas:1.30

breast:2.22

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.32

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:0

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_010583
Gene ID	16428
Unigene ID	Mm.339927
Probe set ID	1417171_at [Mouse430_2]
Ensembl ID	ENSMUSG00000020395

Orthologous Gene

Human[1]	NM_005546
Rat[1]	NM_001108825

Chromosomal Region

Gene Family (Interpro ID)

IPR001849	Pleckstrin homology
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0007202	activation of phospholipase C activity
GO:0002250	adaptive immune response
GO:0001816	cytokine production
GO:0032609	interferon-gamma production
GO:0032633	interleukin-4 production
GO:0001865	NK T cell differentiation
GO:0016310	phosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0005737

cytoplasm

Molecular Function

GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0000166	nucleotide binding
GO:0005543	phospholipid binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

IL2-inducible T-cell kinase

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function