ligase I, DNA, ATP-dependent

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Synonym

LigI, AL033288, Polydeoxyribonucleotide synthase [ATP] 1, mLigI, Lig-1, Lig1, ligase I, DNA, ATP-dependent, DNA ligase 1, DNA ligase I

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.75 cerebellum:6.97 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.54 spine:7.26 retina:7.18 eye:7.54 artery/aorta:- vein:8.28 lymphnode:8.42 peripheral blood:- spleen:8.69 thymus:- bone marrow:11 adipose:6.83 bone:10.46 skin:7.16
CAGE cerebrum:2.28 cerebellum:- brain stem:2.57 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.71 retina:- eye:- artery/aorta:2.14 vein:- lymphnode:3.80 peripheral blood:- spleen:4.23 thymus:3.92 bone marrow:- adipose:- bone:3.69 skin:3.23
RNA-seq cerebrum:2.18 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:3.30 salivary:-
GeneChip uterus:8.68 placenta:6.84 prostate:7.23 ovary:8.26 testis:8.10 heart:6.73 muscle:6.45 esophagus:- stomach:7.89 intestine:8.68 colon:- liver/hepato:6.70 lung:7.07 bladder:7.03 kidney:6.41 pituitary:7.22 thyroid/parathyroid:- adrenal gland:6.89 pancreas:6.54 breast:7.57 salivary:7.18
CAGE uterus:2.88 placenta:2.76 prostate:1.80 ovary:2.88 testis:3.50 heart:- muscle:- esophagus:- stomach:2.85 intestine:3.04 colon:3.18     liver/hepato:1.52    lung:2.61 bladder:2.47 kidney:- pituitary:2.22 thyroid/parathyroid:- adrenal gland:1.92 pancreas:1.61 breast:2.86 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.29 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.65        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001083188
Gene ID 16881
Unigene ID Mm.421129
Probe set ID 1416641_at  [Mouse430_2]
Ensembl ID ENSMUSG00000056394

Orthologous Gene

Human[1]  NM_000234
Rat[2]  NM_001024268, NM_030855

Chromosomal Region

-

Gene Family (Interpro ID)

IPR012310  ATP dependent DNA ligase, central

Link to Pubmed  (Pubmed ID)

7576101
7642116
7671812
8039710
8674531
8696349
8812484
8889548
9001252
9149948
9363683
9859227
10349636
10922068
11042159
11076861
11217851
11896201
12124343
12466851
12477932
12904583
14610273
14681479
15782199
16141072
16141073
18784354
20300987
21267068
21378394
21390131
21655080
21677750
23154201
23469164
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0051301  cell division
GO:0006266  DNA ligation
GO:0051103  DNA ligation during DNA repair
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0006260  DNA replication
GO:0006303  double-strand break repair via nonhomologous end joining
GO:0006273  lagging strand elongation
GO:0006974  response to DNA damage stimulus
GO:0042542  response to hydrogen peroxide

Cellular Component

GO:0005694  chromosome
GO:0005739  mitochondrion
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0003677  DNA binding
GO:0003910  DNA ligase (ATP) activity
GO:0003909  DNA ligase activity
GO:0016874  ligase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding