multiple endocrine neoplasia 1

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Synonym

multiple endocrine neoplasia 1, Menin, AW045611, menin, Men1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:97.20 cerebellum:128.90 brain stem:31.80 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:191.10 spine:47.30 retina:96.40 eye:91.20 artery/aorta:- vein:- lymphnode:226.80 peripheral blood:71.90 spleen:26.30 thymus:39.50 bone marrow:102.60 adipose:- bone:87.70 skin:63.30
GeneChip cerebrum:6.74 cerebellum:6.70 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.26 spine:6.75 retina:4.68 eye:4.81 artery/aorta:- vein:6.47 lymphnode:6.57 peripheral blood:- spleen:6.54 thymus:- bone marrow:6.52 adipose:6.26 bone:5.57 skin:5.34
CAGE cerebrum:2.95 cerebellum:- brain stem:3.01 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.11 retina:- eye:- artery/aorta:2.14 vein:- lymphnode:2.17 peripheral blood:- spleen:2.37 thymus:3.06 bone marrow:- adipose:- bone:2.09 skin:2.50
RNA-seq cerebrum:10.01 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:218.10 placenta:69 prostate:- ovary:68.90 testis:22.20 heart:- muscle:- esophagus:- stomach:163.60 intestine:- colon:70.50     liver/hepato:18.10        lung:80.30    bladder:- kidney:56.40 pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:28.10 breast:111 salivary:54
GeneChip uterus:6.97 placenta:6.52 prostate:6.67 ovary:7.01 testis:6.53 heart:5.65 muscle:5.87 esophagus:- stomach:6.55 intestine:6.30 colon:- liver/hepato:6.41 lung:6.36 bladder:6.05 kidney:6.61 pituitary:6.75 thyroid/parathyroid:- adrenal gland:5.86 pancreas:6.65 breast:5.70 salivary:5.25
CAGE uterus:2.81 placenta:2.76 prostate:2.51 ovary:2.65 testis:2.92 heart:- muscle:- esophagus:- stomach:2.36 intestine:2.65 colon:2.27     liver/hepato:2.58    lung:2.74 bladder:2.33 kidney:- pituitary:2.87 thyroid/parathyroid:- adrenal gland:2.82 pancreas:3.04 breast:2.68 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.59 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.41        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

IDs

Refseq ID NM_001168488
Gene ID 17283
Unigene ID Mm.12917
Probe set ID 1416348_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024947

Orthologous Gene

Human[7]  NM_000244, NM_130799, NM_130800, NM_130801, NM_130802, NM_130803, NM_130804
Rat[1]  NM_019208, NM_130799, NM_130800, NM_130801, NM_130802, NM_130803, NM_130804

Chromosomal Region

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0007050  cell cycle arrest
GO:0016568  chromatin modification
GO:0006338  chromatin remodeling
GO:0009790  embryonic development
GO:0048704  embryonic skeletal system morphogenesis
GO:0030097  hemopoiesis
GO:0034968  histone lysine methylation
GO:0016571  histone methylation
GO:0001776  leukocyte homeostasis
GO:0000165  MAPKKK cascade
GO:0060135  maternal process involved in female pregnancy
GO:0045786  negative regulation of cell cycle
GO:0008285  negative regulation of cell proliferation
GO:0045736  negative regulation of cyclin-dependent protein kinase activity
GO:0046329  negative regulation of JNK cascade
GO:0046621  negative regulation of organ growth
GO:0045668  negative regulation of osteoblast differentiation
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0051974  negative regulation of telomerase activity
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0001503  ossification
GO:0002076  osteoblast development
GO:0002051  osteoblast fate commitment
GO:0060021  palate development
GO:0043065  positive regulation of apoptosis
GO:0043280  positive regulation of caspase activity
GO:0045597  positive regulation of cell differentiation
GO:0051781  positive regulation of cell division
GO:0031062  positive regulation of histone methylation
GO:0045669  positive regulation of osteoblast differentiation
GO:0032092  positive regulation of protein binding
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032925  regulation of activin receptor signaling pathway
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus
GO:0010332  response to gamma radiation
GO:0009411  response to UV
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0000785  chromatin
GO:0032154  cleavage furrow
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0035097  histone methyltransferase complex
GO:0016363  nuclear matrix
GO:0005634  nucleus
GO:0043234  protein complex

Molecular Function

GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0000400  four-way junction DNA binding
GO:0018024  histone-lysine N-methyltransferase activity
GO:0005515  protein binding
GO:0030674  protein binding, bridging
GO:0047485  protein N-terminus binding
GO:0070412  R-SMAD binding
GO:0043565  sequence-specific DNA binding
GO:0000403  Y-form DNA binding