twinfilin, actin-binding protein, homolog 1 (Drosophila)

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Synonym

Twinfilin-1, A6, protein tyrosine kinase 9, Ptk9, twinfilin, actin monomer-binding protein, Protein A6, twf1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:9.07 cerebellum:9.03 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.45 spine:9.19 retina:9.48 eye:9.95 artery/aorta:- vein:10.35 lymphnode:9.48 peripheral blood:- spleen:8.94 thymus:- bone marrow:8.90 adipose:9.91 bone:9.18 skin:9.52
CAGE cerebrum:3.27 cerebellum:- brain stem:3.37 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.54 retina:- eye:- artery/aorta:3.72 vein:- lymphnode:4.03 peripheral blood:- spleen:2.83 thymus:2.98 bone marrow:- adipose:- bone:2.77 skin:3.69
RNA-seq cerebrum:3.92 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:10.25 placenta:10.06 prostate:10.73 ovary:10.05 testis:8.34 heart:8.44 muscle:8.04 esophagus:- stomach:10.64 intestine:11.01 colon:- liver/hepato:9.78 lung:9.64 bladder:10.47 kidney:10.63 pituitary:10.04 thyroid/parathyroid:- adrenal gland:10.17 pancreas:8.87 breast:9.44 salivary:9.63
CAGE uterus:3.92 placenta:3.51 prostate:3.73 ovary:3.72 testis:3.06 heart:- muscle:- esophagus:- stomach:4.20 intestine:4.23 colon:4.15     liver/hepato:3.52    lung:3.64 bladder:3.92 kidney:- pituitary:3.69 thyroid/parathyroid:- adrenal gland:3.83 pancreas:3.10 breast:3.63 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.50 esophagus:- stomach:- intestine:- colon:-     liver/hepato:5.94        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008971
Gene ID 19230
Unigene ID -
Probe set ID 1420875_at  [Mouse430_2]
Ensembl ID ENSMUSG00000022451

Orthologous Gene

Human[2]  NM_001242397, NM_002822
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR002108  Actin-binding, cofilin/tropomyosin type

Link to Pubmed  (Pubmed ID)

7671812
8889548
9249064
10349636
10669753
10922068
11042159
11076861
11217851
11604420
12207032
12466851
12477932
12520002
12807912
14610273
14681479
15188402
15226823
15282541
15489334
15782199
16141072
16141073
16511569
16602821
17967808
18625842
18837697
21267068
21677750
21731673
23912999

Gene Ontology  (GO ID)

Biological Process

GO:0051016  barbed-end actin filament capping
GO:0030837  negative regulation of actin filament polymerization
GO:0006468  protein amino acid phosphorylation
GO:0043538  regulation of actin phosphorylation
GO:0042989  sequestering of actin monomers

Cellular Component

GO:0015629  actin cytoskeleton
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0030175  filopodium
GO:0005622  intracellular
GO:0030016  myofibril
GO:0048471  perinuclear region of cytoplasm
GO:0032587  ruffle membrane

Molecular Function

GO:0003779  actin binding
GO:0003785  actin monomer binding
GO:0005524  ATP binding
GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0032403  protein complex binding
GO:0004713  protein tyrosine kinase activity