receptor (TNFRSF)-interacting serine-threonine kinase 2

 jump to detail

Synonym

Ripk2, RICK, D4Bwg0615e, CARDIAK, CARD3, CCK

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:32.10 eye:7.60 artery/aorta:- vein:- lymphnode:10.80 peripheral blood:43.10 spleen:158 thymus:- bone marrow:- adipose:- bone:87.70 skin:15.80
GeneChip cerebrum:5.85 cerebellum:5.76 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.16 spine:5.95 retina:5.55 eye:6.31 artery/aorta:- vein:6.63 lymphnode:6.95 peripheral blood:- spleen:7.04 thymus:- bone marrow:6.47 adipose:6.47 bone:6.45 skin:6.67
CAGE cerebrum:1.81 cerebellum:- brain stem:1.67 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.70 retina:- eye:- artery/aorta:3.40 vein:- lymphnode:3.82 peripheral blood:- spleen:2.97 thymus:2.22 bone marrow:- adipose:- bone:2.77 skin:3.53
RNA-seq cerebrum:1.33 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:- ovary:23 testis:- heart:18.60 muscle:71 esophagus:- stomach:65.50 intestine:- colon:17.60     liver/hepato:-        lung:10    bladder:- kidney:8.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:37.50 breast:32.60 salivary:-
GeneChip uterus:6.85 placenta:6.77 prostate:6.19 ovary:6.47 testis:5.81 heart:6.25 muscle:5.77 esophagus:- stomach:6.70 intestine:6.61 colon:- liver/hepato:6.26 lung:6.79 bladder:6.52 kidney:5.79 pituitary:6.63 thyroid/parathyroid:- adrenal gland:5.90 pancreas:6.18 breast:6.02 salivary:6.41
CAGE uterus:3.21 placenta:2.49 prostate:3.10 ovary:3.18 testis:1.80 heart:- muscle:- esophagus:- stomach:2.60 intestine:2.13 colon:2.30     liver/hepato:3.13    lung:3.09 bladder:2.87 kidney:- pituitary:2.48 thyroid/parathyroid:- adrenal gland:2.83 pancreas:2.45 breast:1.78 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.79 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.26        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_138952
Gene ID 192656
Unigene ID Mm.112765
Probe set ID 1450173_at  [Mouse430_2]
Ensembl ID ENSMUSG00000041135

Orthologous Gene

Human[2]  NM_003821
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001315  Caspase Recruitment
IPR011029  DEATH-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8812455
9371744
9575181
10349636
11042159
11076861
11217851
11894097
11894098
12091384
12466851
12477932
14610273
14638696
14663141
15190255
15203566
15289440
15489334
15620648
15661922
15691841
15691843
15761153
15782199
16141072
16141073
16413926
16418290
17277144
17403772
17433728
17452523
17562858
17579072
17635956
17947236
17961803
18079694
18085666
18261938
18310079
18403232
18511561
18522545
18566542
19188356
19213760
19360122
19464198
19473975
19805227
19853061
19933833
20351139
20668698
20685341
20921147
20949042
21123652
21135058
21205640
21236705
21469090
21552281
21606507
21683629
21731762
21844230
21887730
21895414
21959219
22033934
22314416
22491249
22509021
22520462
22547547
22607974
22747758
22807671
22905357
22914170
23321697
23356698
23525089
23892723
23918989
23952047
24062413
24477914

Gene Ontology  (GO ID)

Biological Process

GO:0002250  adaptive immune response
GO:0006915  apoptosis
GO:0071222  cellular response to lipopolysaccharide
GO:0071223  cellular response to lipoteichoic acid
GO:0071224  cellular response to peptidoglycan
GO:0050830  defense response to Gram-positive bacterium
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0045087  innate immune response
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0070427  nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431  nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0016310  phosphorylation
GO:0046641  positive regulation of alpha-beta T cell proliferation
GO:0043065  positive regulation of apoptosis
GO:0032722  positive regulation of chemokine production
GO:0001961  positive regulation of cytokine-mediated signaling pathway
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0033091  positive regulation of immature T cell proliferation
GO:0032729  positive regulation of interferon-gamma production
GO:0032743  positive regulation of interleukin-2 production
GO:0032755  positive regulation of interleukin-6 production
GO:0046330  positive regulation of JNK cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0031398  positive regulation of protein ubiquitination
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0045627  positive regulation of T-helper 1 cell differentiation
GO:0002827  positive regulation of T-helper 1 type immune response
GO:0032760  positive regulation of tumor necrosis factor production
GO:0006468  protein amino acid phosphorylation
GO:0042981  regulation of apoptosis
GO:0043281  regulation of caspase activity
GO:0043330  response to exogenous dsRNA
GO:0070555  response to interleukin-1
GO:0070671  response to interleukin-12
GO:0070673  response to interleukin-18
GO:0042098  T cell proliferation
GO:0050852  T cell receptor signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005622  intracellular

Molecular Function

GO:0005524  ATP binding
GO:0050700  CARD domain binding
GO:0016301  kinase activity
GO:0030274  LIM domain binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0000166  nucleotide binding
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups